Clot-Busting drug shows promise for sudden blindness in eye artery blockage

NCT ID NCT04526951

First seen Sep 30, 2025 · Last updated May 05, 2026 · Updated 33 times

Summary

This study tested whether a clot-dissolving medicine called tenecteplase can restore vision in people who suddenly lose sight due to a blocked artery in the eye. 81 adults with central retinal artery occlusion received either tenecteplase or a placebo within 4.5 hours of symptoms. The main goal was to see if the drug improved vision after 30 days.

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Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Denmark

  • Bispebjerg University Hospital

    Copenhagen, Denmark

  • Haukeland University Hospital

    Bergen, Norway

  • Helse Nord Trøndelag Trust

    Namsos, Norway

  • Helsinki University Hospital

    Helsinki, Finland

  • Karolinska University Hospital

    Stockholm, Sweden

  • Kauno Klinikos Kaunas

    Kaunas, Lithuania

  • Oslo University Hospital

    Oslo, 0424, Norway

  • Rigshospitalet University Hospital

    Copenhagen, Denmark

  • St Olav University Hospital

    Trondheim, Norway

  • Telemark Hospital Trust

    Skien, Norway

  • Turku University Hospital

    Turku, Finland

  • University Hospital Antwerp

    Antwerp, Belgium

  • University Hospital Leuven

    Leuven, 3000, Belgium

  • Vestfold Hospital Trust

    Tønsberg, Norway

  • Vestre Viken Hospital Trust Drammen

    Drammen, Norway

  • Vilnius University Hospital

    Vilnius, Lithuania

  • Østfold Hospital Trust Kalnes, Dept of Ophthalmology

    Grålum, Norway

Conditions

Explore the condition pages connected to this study.