New injection shows promise for taming autoimmune attack in Sjogren's syndrome

NCT ID NCT05673993

Completed Disease control Sponsor: RemeGen Co., Ltd. Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether weekly injections of a drug called telitacicept could safely reduce disease activity in adults with active primary Sjogren's syndrome. For 48 weeks, 381 participants received either one of two doses of the drug or a placebo injection, with the option for some to switch to the active drug later. The main goal was to see if the drug lowered a comprehensive disease activity score that measures how the condition affects different body systems.

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Contacts and locations

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Locations

Affiliated Hospital of Hebei University

Baoding, Hebei, China
Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, China
Anhui Provincial Hospital

Hefei, Anhui, China
Beijing Tongren Hospital, Capital Medical University

Beijing, Beijing Municipality, China
Binzhou Medical University Hospital

Binzhou, Shandong, China
Deyang People's Hospital

Deyang, Sichuan, China
Dongyang People's Hospital

Dongyang, Zhejiang, China
First Affiliated Hospital of Gannan Medical University

Ganzhou, Jiangxi, China
Ganzhou People's Hospital

Ganzhou, Jiangxi, China
General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China
Guilin People's Hospital

Guilin, Guangxi, China
Hebei PetroChina Central Hospital

Langfang, Hebei, China
Henan Provincial People's Hospital

Zhengzhou, Henan, China
Hunan Provincial People's Hospital

Changsha, Hunan, China
Huzhou Third Municipal Hospital

Huzhou, Zhejiang, China
Jiangsu Province Hospital

Nanjing, Jiangsu, China
Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, China
Jilin Province People's Hospital

Changchun, Jilin, China
Jinhua Municipal Central Hospital

Jinhua, Zhejiang, China
Jining No 1 People's Hospital

Jining, Shandong, China
Liuzhou Workers' Hospital

Liuchow, Guangxi, China
Meizhou People's Hospital

Meizhou, Guangdong, China
Mianyang Central Hospital

Mianyang, Sichuan, China
Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China
Ningbo Medical Center (Lihuili Hospital)

Ningbo, Zhejiang, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, China
Peking University Shougang Hospital

Beijing, Beijing Municipality, China
People's Hospital of Xinjiang Uygur Autonomous Region

Ürümqi, Xinjiang, China
People's Hospital of Zhengzhou

Zhengzhou, Henan, China
Pingxiang People's Hospital

Pingxiang, Jiangxi, China
Qilu Hospital of Shandong University

Jinan, Shandong, China
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China
Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, China
Shandong Provincial Hospital

Jinan, Shandong, China
Shanghai Ninth People's Hopital, Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China
Shanxi Bethune Hospital

Taiyuan, Shanxi, China
Shanxi Provincial People's Hospital

Taiyuan, Shanxi, China
Shengjing Hospital of China Medical University

Shenyang, Liaoning, China
Shenzhen People's Hospital

Shenzhen, Guangdong, China
South China Hospital of Shenzhen University

Shenzhen, Guangdong, China
Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China
The Affiliated Hospital of Guizhou Medical University

Guiyang, Guizhou, China
The Affiliated Hospital of Zunyi Medical University

Zunyi, Guizhou, China
The First Affiliated Hospital of Army Medical University

Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Bengbu Medical College

Bengbu, Anhui, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China
The First Hospital of China Medical University

Shenyang, Liaoning, China
The First Hospital of Jiaxing

Jiaxing, Zhejiang, China
The First People's Hospital of Changde

Changde, Hunan, China
The First People's Hospital of Chenzhou

Chenzhou, Hunan, China
The First People's Hospital of Wenling

Wenling, Zhejiang, China
The First People's Hospital of Yunnan Province

Kunming, Yunnan, China
The People's Hospital of Wenzhou

Wenzhou, Zhejiang, China
The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China
The Second Affiliated Hospital of Guilin Medical University

Guilin, Guangxi, China
The Second Affiliated Hospital of Hebei Medical University

Shijiazhuang, Hebei, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
The Second Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The Second Hospital of Jiaxing

Jiaxing, Zhejiang, China
The Second People's Hospital of Changzhou

Changzhou, Jiangsu, China
The Third Xiangya Hospital of Central South University

Changsha, Hunan, China
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China
West China Hospital Sichuan University

Chengdu, Sichuan, China
Xiangya Hospital of Central South University

Changsha, Hunan, China
Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, China
Yanbian University Hospital (Yanbian Hospital)

Yanji, Jilin, China
Yantai Yuhuangding Hospital

Yantai, Shandong, China
Yantaishan Hospital

Yantai, Shandong, China
Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China
Zhongshan Hospital of Traditional Chinese Medicine

Zhongshan, Guangdong, China
Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Conditions

Explore the condition pages connected to this study.

PRIMARY SJOGREN'S SYNDROME