New drug telitacicept aims to tame Sjögren's in major trial

NCT ID NCT07404865

Recruiting now Disease control Sponsor: Vor Biopharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This Phase 3 study tests whether telitacicept, a biologic drug given as a shot, can reduce disease activity in adults with active primary Sjögren's disease. About 250 participants will receive either telitacicept or a placebo for 48 weeks. The main goal is to see if the drug improves a standard disease activity score.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: telitacicept (a biologic drug given as a shot under the skin)
What this could lead to: If it works, telitacicept could become a new treatment option to control Sjögren's disease activity and improve symptoms.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not work better than placebo, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Sjogren syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY SJOGREN'S DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Accurate Clinical Research
RECRUITING

Baytown, Texas, 77521, United States
Accurate Clinical Research, Inc.
RECRUITING

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research, Inc.
RECRUITING

Houston, Texas, 77089, United States
Allen Arthritis
RECRUITING

Allen, Texas, 75013, United States
Altoona Center for Clinical Research, P.C.
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Amarillo Premier Research, LLC
RECRUITING

Amarillo, Texas, 79124, United States
Arizona Arthritis & Rheumatology Associates P.C.
RECRUITING

Chandler, Arizona, 85225, United States
Arizona Arthritis & Rheumatology Associates P.C.
RECRUITING

Flagstaff, Arizona, 86001, United States
Arizona Arthritis & Rheumatology Associates P.C.
RECRUITING

Phoenix, Arizona, 85392, United States
Arizona Arthritis & Rheumatology Associates, P.C.
RECRUITING

Tucson, Arizona, 85704, United States
Arizona Arthritis & Rheumatology Associates, PLLC
RECRUITING

Glendale, Arizona, 85306, United States
Arthritis and Rheumatism Associates
RECRUITING

Rockville, Maryland, 20850, United States
Arthritis and Rheumatology Research Institute, PLLC
RECRUITING

Allen, Texas, 75013, United States
Bioresearch Partner
RECRUITING

South Miami, Florida, 33143, United States
Bioresearch Partners
RECRUITING

South Miami, Florida, 33143, United States
Chicago Clinical Research Institute Inc
RECRUITING

Chicago, Illinois, 60607, United States
Clinical Investigation Specialist
RECRUITING

Schaumburg, Illinois, 60195, United States
Clinical Research Institute of Michigan, LLC
RECRUITING

Saint Clair Shores, Michigan, 48081, United States
Clinical Research of West Florida - Corporate
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research of West Florida, Inc.
RECRUITING

Tampa, Colorado, 33606, United States
Clinical Research of West Florida, Inc.
RECRUITING

Clearwater, Florida, 33765, United States
Conquest Research
RECRUITING

Winter Park, Florida, 32789, United States
Denver Arthritis Clinic
RECRUITING

Denver, Colorado, 80230, United States
Finlay Medical Research Corp
RECRUITING

Green Acres, Florida, 33467, United States
Helios CR Inc - Dallas, TX
RECRUITING

Dallas, Texas, 75231, United States
Lone Star Arthritis & Rheumatology
RECRUITING

Fort Worth, Texas, 76109, United States
Novel Research LLC
RECRUITING

Bellaire, Texas, 77401, United States
Precision Comprehensive Clinical Research Solution
RECRUITING

Irving, Texas, 75061, United States
Precision Comprehensive Clinical Research Solutions
RECRUITING

Euless, Texas, 76040, United States
R&H Clinical Research Inc.
RECRUITING

Katy, Texas, 77450, United States
Rheumatic Disease Associates, Ltd.
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
St. Luke's Clinic - Rheumatology
RECRUITING

Boise, Idaho, 83702, United States
Suncoast Clinical Research Inc.
RECRUITING

New Port Richey, Florida, 34652, United States
Tekton Research
RECRUITING

Fort Collins, Colorado, 80528, United States
Tidewater Clinical Research
RECRUITING

Chesapeake, Virginia, 23320, United States
Velocity Clinical Research, Waco
RECRUITING

Waco, Texas, 76710, United States
Wallace Rheumatic Study Center
RECRUITING

Beverly Hills, California, 90210, United States
Willow Rheumatology & Wellness
RECRUITING

Willowbrook, Illinois, 60527, United States