New pill tebapivat aims to ease anemia in sickle cell disease
NCT ID NCT06924970
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether tebapivat, an oral tablet, can improve anemia in people with sickle cell disease compared to a placebo. About 59 participants will take the drug or a dummy pill for several weeks. The main goal is to see if hemoglobin levels rise, which could mean fewer symptoms and complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tebapivat (oral tablet)
What this could lead to
If successful, tebapivat could offer a new oral treatment option to improve anemia and reduce complications in people with sickle cell disease.
What could go wrong
This is an early Phase 2 trial with only 59 participants, so results may not apply to everyone. The drug may not work better than placebo or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam Universitair Medisch Centrum, Locatie AMC
Amsterdam, North Holland, 1105AZ, Netherlands
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Boston Medical Center & Boston University School of Medicine
Boston, Massachusetts, 02118, United States
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CHR de la Citadelle
Liège, Wallonne, 4000, Belgium
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CHU Hôpital Henri Mondor
Créteil, Île-de-France Region, 94010, France
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CHU Montreal
Montreal, Quebec, H2X 3E4, Canada
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Children's Hospital of Michigan
Detroit, Michigan, 48304, United States
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Children's National Hospital
Washington D.C., District of Columbia, 20010, United States
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Clinique CHC MontLégia
Liège, Wallonne, 4420, Belgium
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Emory-Children's Center/ Children's Healthcare of Atlanta: Arthur M. Blank Hospital
Atlanta, Georgia, 30322, United States
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Erasmus MC
Rotterdam, South Holland, 3015 GD, Netherlands
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Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust
London, SE5 9RS, United Kingdom
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Fred Hutchinson Cancer Center, University of Washington
Seattle, Washington, 98195, United States
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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Hôpital Edouard Herriot, CHU de Lyon
Lyon, Auvergne-Rhône-Alpes, 69003, France
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Icahn School of Medicine at Mt. Sinai
New York, New York, 10029, United States
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Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse, Midi Pyrenees, 31059, France
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Kings College Hospital NHS Foundation Trust
London, SE5 9RS, United Kingdom
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Lifespan at Rhode Island Hospital
Providence, Rhode Island, 02903-4923, United States
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MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Montefiore Medical Center
The Bronx, New York, 10460, United States
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Prisma Health Cancer Institute - Farris Road
Greenville, South Carolina, 29605, United States
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St. James Hospital
Dublin, Leinster, D08 A978, Ireland
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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UCHealth at University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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UConn Health
Farmington, Connecticut, 06030-0001, United States
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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University College London
London, WC1E 6BT, United Kingdom
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Texas Health Science Center of Houston
Houston, Texas, 77030, United States