Engineered immune cells take aim at hard-to-treat cancers in early trial

NCT ID NCT05035407

First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 34 times

Summary

This early-phase trial tested a personalized cell therapy for adults with advanced cancers (stomach, breast, lung, cervical, and others) that carry a protein called KK-LC-1. Researchers took participants' own immune cells, modified them in the lab to better recognize and attack cancer, and infused them back along with a drug to help the cells survive. The main goal was to find the safest dose and check for side effects. The study was terminated early, so final results are limited.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

Explore the condition pages connected to this study.