New TB prevention dosing study aims to protect children from active disease

NCT ID NCT03730181

First seen May 08, 2026 · Last updated May 25, 2026 · Updated 4 times

Summary

This study tested two medicines, rifapentine and isoniazid, to prevent active tuberculosis (TB) in children up to 12 years old who had latent (hidden) TB infection. The goal was to find the safest and most effective dose for both HIV-infected and HIV-uninfected children. Researchers measured drug levels in the blood and monitored for side effects to create a dosing guide for pediatric use.

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Contacts and locations

Locations

  • Desmond Tutu TB Center, University of Stellenbosch

    Stellenbosch, South Africa

Conditions

Explore the condition pages connected to this study.