Heart valve implant trial aims to stop moderate disease from worsening

NCT ID NCT05149755

Ongoing Disease control Sponsor: Medtronic Cardiovascular Source: ClinicalTrials.gov ↗

Summary

This study is testing if a minimally invasive procedure to replace a narrowed heart valve (TAVR) is better than standard medications alone for people with moderate aortic stenosis. It will enroll 650 participants who have the condition along with other signs of heart strain or risk. The main goal is to see if the procedure helps people live longer and avoid serious complications or hospital stays compared to just taking medications.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Abrazo Arizone Heart Hospital

Phoenix, Arizona, 85016, United States
Allgemeines Krankenhaus - Universitätskliniken Wien

Vienna, 1030, Austria
Ascension Saint John Hospital

Detroit, Michigan, 48236, United States
Aurora Saint Lukes Medical Center

Milwaukee, Wisconsin, 53215, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
CHRU Brest - Hôpital de la Cavale Blanche

Brest, 29609, France
CHU de Liege- Hopital du Sart Tilman

Liège, 4000, Belgium
CHU de Rennes - Hôpital Pontchaillou

Rennes, Brittany Region, France
Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24014, United States
Catharina Ziekenhuis

Eindhoven, Netherlands, Netherlands
Catholic Medical Center

Manchester, New Hampshire, 03102, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Complejo Asistencial Universitario de Salamanca

Salamanca, 37007, Spain
Deborah Heart and Lung Center

Browns Mills, New Jersey, 08015, United States
Englewood Hospital & Medical Center

Englewood, New Jersey, 076931, United States
Erasmus MC

Rotterdam, Netherlands, 3015, Netherlands
Erlanger Medical Center

Chattanooga, Tennessee, 37403, United States
Fiona Stanley Hospital

Murdoch, 6150, Australia
Galway University Hospitals - University Hospital Galway (UHG)

Galway, H91 YR71, Ireland
Hartford Hospital

Hartford, Connecticut, 06106, United States
Herzzentrum Leipzig GmbH

Leipzig, 04289, Germany
HonorHealth Scottsdale Shea Medical Center

Scottsdale, Arizona, 85260, United States
Hospital Clínico Universitario de Valladolid

Valladolid, 47006, Spain
Hospital Universitari Clínic de Barcelona

Barcelona, Spain, 08036, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Hôpital Européen Georges Pompidou

Paris, 75015, France
IRCCS Policlinico San Donato

San Donato Milanese, 20097, Italy
Inselspital - Universitätsspital Bern

Bern, 3010, Switzerland
Institut Médico-Chirurgical Montsouris

Paris, 75014, France
Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)

Québec, Quebec, G1V 4G5, Canada
Intermountain Cardiovascular and Thoracic Surgery

Salt Lake City, Utah, 84111, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Kath Saint Johannes-Gesellschaft Dortmund gGmbH Saint Johannes-Hospital Dortmund

Dortmund, 44137, Germany
Kawasaki Saiwai Hospital

Kawasaki, Kanagawa, 212-0014, Japan
Kettering Health Main Campus

Kettering, Ohio, 45429, United States
Klinikum der Universität München - Campus Grosshadern

München, 15, 81377, Germany
Lehigh Valley Hospital, Inc

Allentown, Pennsylvania, 18103, United States
London Health Sciences Centre- University Campus

London, Ontario, N6C 2R5, Canada
Los Robles Hospital & Medical Center

Thousand Oaks, California, 91360, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical City Dallas

Dallas, Texas, 75230, United States
Methodist Hospital San Antonio

San Antonio, Texas, 78229, United States
Mission Hospital

Asheville, North Carolina, 28801, United States
Montreal Heart Hospital

Montreal, Quebec, H1T1C8, Canada
Monument Health Rapid City Hospital

Rapid City, South Dakota, 57701, United States
Morton Plant Hospital

Clearwater, Florida, 33756, United States
Northwell Health

Manhasset, New York, 11030, United States
Oregon Health & Science University Hospital

Portland, Oregon, 97239, United States
Orlando Health

Orlando, Florida, 32806, United States
Osaka Keisatsu Hospital

Osaka, 543-0035, Japan
Osaka University Hospital

Osaka, 565-0871, Japan
Ospedale San Raffaele - Milano

Milan, 20132, Italy
Presidio Ospedaliero Gaspare Rodolico

Catania, 95123, Italy
Providence Sacred Heart Medical Center & Children's Hospital

Spokane, Washington, 99204, United States
Queen Elizabeth II Health Sciences Centre

Halifax, B3H 3A7, Canada
Rabin Medical Center- Beilinson Hospital

Petah Tikva, Israel, 49100, Israel
SSM Health Saint Louis University Hospital

St Louis, Missouri, 63110, United States
Saint Bartholomew's Hospital

London, EC1A 7BE, United Kingdom
Saint Vincent's Medical Center Riverside

Jacksonville, Florida, 32204, United States
Saint Vincents Medical Center

Bridgeport, Connecticut, 06606-4201, United States
Shaare Zedek Medical Center

Jerusalem, Israel, 9103102, Israel
Shonan Kamakura General Hospital

Kanagawa, Kamakura, 247-8533, Japan
Skanes Universitetssjukhus

Lund, 22185, Sweden
Spectrum Health

Grand Rapids, Michigan, 49503, United States
St Antonius Ziekenhuis

Nieuwegein, 3435, Netherlands
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Tallahassee Memorial Hospital

Tallahassee, Florida, 32308-5054, United States
Tampa General Hospital

Tampa, Florida, 33620, United States
Terrebonne General Medical Center

Houma, Louisiana, 70360, United States
Texas Health Harris Methodist Hospital Fort Worth

Fort Worth, Texas, 76104, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
The Mount Sinai Hospital

New York, New York, 10029, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The University of Vermont

Burlington, Vermont, 05401-1473, United States
Tokai University Hospital

Isehara, Kanagawa, 259-1193, Japan
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UPMC Pinnacle Harrisburg Campus

Harrisburg, Pennsylvania, 17101, United States
Universitair Medisch Centrum Groningen

Groningen, 9713 GZ, Netherlands
University Hospital Sankt Poelten

Sankt Pölten, Austria, 3100, Austria
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106-1716, United States
University of Alabama at Birmingham (UAB) Hospital

Birmingham, Alabama, 35233, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Florida

Gainesville, Florida, 32608, United States
University of Michigan Health System - University Hospital

Ann Arbor, Michigan, 48109-1274, United States
Universitäts-Herzzentrum Freiburg - Bad Krozingen

Bad Krozingen, 79189, Germany
Universitätsklinikum Bonn

Bonn, 53217, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, 55131, Germany
Wake Forest University Heatlh Sciences

Winston-Salem, North Carolina, 27157, United States
West Virginia University

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

MODERATE AORTIC VALVE STENOSIS