New hope for rare, aggressive cancers: immune therapy targets hard-to-treat tumors

NCT ID NCT07061080

Recruiting now Disease control Sponsor: Grupo Espanol de Tumores Neuroendocrinos Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called tarlatamab, which helps the immune system find and attack cancer cells. It is for people with advanced neuroendocrine carcinomas of the digestive system or unknown origin, a rare and aggressive cancer with limited treatment options. About 87 participants will receive tarlatamab alone or with standard chemotherapy to see if it can slow tumor growth and improve survival.

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Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine neoplasm neuroendocrine carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED NEUROENDOCRINE CARCINOMAS OF THE DIGESTIVE SYSTEM ADVANCED NEUROENDOCRINE CARCINOMAS UNKNOWN PRIMARY ORIGIN

Contacts and locations

Locations

Brest University Hospital Centre
NOT_YET_RECRUITING

Brest, Brest, 29200, France
Centre Hospitalier Universitaire de Toulouse
NOT_YET_RECRUITING

Toulouse, Toulouse, 31300, France
Centre Oscar Lambret
NOT_YET_RECRUITING

Lille, Lille, 59020, France
Centre Régional de Lutte Contre le Cancer Institut Bergonié (Bordeaux)
NOT_YET_RECRUITING

Bordeaux, Cedex, 33076, France
Gustave Roussy
NOT_YET_RECRUITING

Villejuif, Villejuif,, 94800, France
H.U Germans Trias i Pujols
NOT_YET_RECRUITING

Badalona, Barcelona, 08916, Spain
H.U La Paz
NOT_YET_RECRUITING

Madrid, Madrid, 28046, Spain
H.U Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Madrid, 28034, Spain
H.U. Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital 12 de Octubre
NOT_YET_RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Clínico Universitario de Santiago
NOT_YET_RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Hospital General Universitario Gregorio Marañón
NOT_YET_RECRUITING

Madrid, Madrid, 28007, Spain
Hospital Universitario Marqués de Valdecilla
NOT_YET_RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Miguel Servet
NOT_YET_RECRUITING

Zaragoza, Zaragoza, 50009, Spain
Hospital Universitario de Burgos (HUBU)
NOT_YET_RECRUITING

Burgos, Burgos, 09006, Spain
Hospital Universitario y Politécnico La Fe
NOT_YET_RECRUITING

Valencia, Valencia, 46026, Spain
Hôpital Edouard Herriot (Hospices Civils Lyon)
NOT_YET_RECRUITING

Lyon, Lyon, 69003, France
Institut de Cancérologie de Lorraine (CLCC) Nancy
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, Vandœuvre-lès-Nancy Cedex, 54519, France
Institut de Cancérologie de l'Ouest (Angers/Nantes)
NOT_YET_RECRUITING

Nantes, Nantes, France