New inhaler aims to quiet chronic cough

NCT ID NCT06504446

Ongoing Symptom relief Sponsor: Nocion Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental inhaler called taplucainium (NOC-110) in 455 adults with chronic cough that has lasted at least a year and hasn't been helped by other treatments. Participants will take the inhaler or a placebo once daily for several weeks. The main goal is to see if the drug reduces the number of coughs per hour.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

taplucainium inhalation powder

What this could lead to

If it works, this could provide a new treatment option to reduce coughing in people with chronic cough that hasn't responded to other therapies.

What could go wrong

This is a mid-stage trial, so results are not yet proven. The drug may not reduce coughs significantly or could have side effects. It's also only for a specific type of chronic cough.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for REFRACTORY OR UNEXPLAINED CHRONIC COUGH are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY OR UNEXPLAINED CHRONIC COUGH

Contacts and locations

Show contact details

Locations

AMR Las Vegas

Las Vegas, Nevada, 89119, United States
AMR Phoenix

Tempe, Arizona, 85281, United States
AZ Delta

Roeselare, 8800, Belgium
AZ Sint-Maarten

Mechelen, 2800, Belgium
Accellacare

Winston-Salem, North Carolina, 27103, United States
Accellacare

Mt. Pleasant, South Carolina, 29464, United States
Accellacare d/b/a Accellacare of Knoxville

Knoxville, Tennessee, 37938, United States
Accellacare of McFarland Clinic

Ames, Iowa, 50010, United States
Aeroallergy Research Laboratories of Savannah, Inc.

Savannah, Georgia, 31406, United States
Alamo ENT Associates

San Antonio, Texas, 78258, United States
Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. Z .O.O.

Tarnów, 33-100, Poland
Allergy & Asthma Associates of Santa Clara Valley

San Jose, California, 95117, United States
Allergy & Asthma Specialists, PSC

Owensboro, Kentucky, 42301, United States
Allergy Partners Clinical Research

Asheville, North Carolina, 28803, United States
Allergy Partners of New Jersey P C

Ocean City, New Jersey, 07712, United States
Allergy and Asthma Associates of Southern California dba Southern California Research

Laguna Niguel, California, 92677, United States
Allergy and Asthma Clinical Research Inc

Walnut Creek, California, 94598, United States
Allergy, Asthma & Sinus Center, SC

Greenfield, Wisconsin, 53228, United States
Allergy, Asthma, and Immunology Medical Group

Ventura, California, 93003, United States
BLC Clinical Research

Burlington, Ontario, L7N 3V2, Canada
Belfast City Hospital

Belfast, Belfast, BT9 7AB, United Kingdom
Bluegrass Allergy Research

Lexington, Kentucky, 40509, United States
California Allergy & Asthma Medical Group Inc.

San Jose, California, 95117, United States
Care Access Research - Warwick 1

Warwick, Rhode Island, 02886, United States
Castle Hill Hospital

Cottingham, East Riding of Yorkshire, HU16 5JQ, United Kingdom
Center for Clinical Trials, LLC

Paramount, California, 90723, United States
Centrum Medyczne Lucyna Andrzej Dymek s.c.

Strzelce Opolskie, 47-100, Poland
Centrum Medyczne Pratia Bydgoszcz

Bydgoszcz, 85-796, Poland
Centrum Medyczne Pratia Czestochowa

Częstochowa, 42-217, Poland
Clinical Research Institute

Minneapolis, Minnesota, 55402, United States
Clinical Research of Gastonia

Gastonia, North Carolina, 28054, United States
Clinical Research of Rock Hill

Rock Hill, South Carolina, 29732, United States
Clinical Site Partners, LLC Leesburg dba Flourish Research

Leesburg, Florida, 34748, United States
Clinical Site Partners, LLC Orlando dba Flourish Research

Winter Park, Florida, 32789, United States
Clinique Specialisee en Allergie de la Capitale

Québec, Quebec, G1V 4W2, Canada
Clinique de pneumologie et du sommeil de Lanaudière

Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
Continental Clinical Solutions, LLC

Towson, Maryland, 21204, United States
DIEX Recherche Quebec Inc.

Québec, Quebec, G1V 4T3, Canada
DIEX Recherche Sherbrooke Inc.

Sherbrooke, Quebec, J1L 0H8, Canada
DIEX Recherche Victoriaville Inc.

Victoriaville, Quebec, G6P 3Z8, Canada
DaVinci Research LLC.

Roseville, California, 95661, United States
Duly Health and Care

Winfield, Illinois, 60190, United States
Dynamic Drug Advancement

Ajax, Ontario, L1S 2J5, Canada
Equity Medical LLC

New York, New York, 10023, United States
G & L Research, LLC

Foley, Alabama, 36535, United States
Gabinet Pulmonologii i Diagnostyki Chorób Alergicznych Dorota Maria Małosek

Szczecin, 70-1111, Poland
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Infinity Medical Research Inc

Russells Mills, Massachusetts, 02747, United States
Innovative Research of West Florida, Inc.

Clearwater, Florida, 33756, United States
Inspiration Research Limited

Toronto, Ontario, M5T 3A9, Canada
Internal Medicine and Pediatric Associates of Bristol, PC

Bristol, Tennessee, 37620, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
King's College Hospital

London, Greater London, SE5 9RS, United Kingdom
Little Rock Allergy & Asthma, P.A. Clinical Research Center

Little Rock, Arkansas, 72205, United States
Lowcountry Lung and Critical Care, P.A.

Charleston, South Carolina, 29406, United States
Lungenzentrum Darmstadt

Darmstadt, Hesse, 64283, Germany
Lynn Health Science Institute

Oklahoma City, Oklahoma, 73112, United States
Lynn Institute of Denver

Aurora, Colorado, 80012, United States
M3 Wake Research, Inc.

Raleigh, North Carolina, 27612, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
McMaster University

Hamilton, Ontario, L8N 3Z5, Canada
Medaimun GmbH

Frankfurt am Main, Hesse, 60596, Germany
Medical Research of Arizona

Scottsdale, Arizona, 85251, United States
Midwest Chest Consultants

Saint Charles, Missouri, 63301, United States
Montana Medical Research, Inc.

Missoula, Montana, 59808, United States
NewportNativeMD,Inc

Newport Beach, California, 92663, United States
North Tyneside General Hospital

North Shields, Tyne & Wear, NE29 8NH, United Kingdom
Northwest Research Center

Portland, Oregon, 97202, United States
Nottingham City Hospital

Nottingham, Nottinghamshire, NG56EG, United Kingdom
Omega Research Debary, LLC

DeBary, Florida, 32713, United States
Ormeau Clinical Trials Ltd

Belfast, Belfast, BT2 8BG, United Kingdom
Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

Ostrowiec Świętokrzyski, 27-400, Poland
Paradigm Clinical Research Centers, LLC

Redding, California, 96001, United States
Paradigm Clinical Research Centers, LLC - Modesto

Modesto, California, 95355, United States
Pharmaceutical Research & Consulting, Inc.

Dallas, Texas, 75231, United States
Pneumocare

Namur, 5380, Belgium
Pneumologicum Halle

Halle, Saxony-Anhalt, 06108, Germany
Pneumologisches Forschungsinstitut Hohegeest GbR

Geesthacht, Schleswig-Holstein, Germany
Pneumologisches Studienzentrum MVZ "Die Lungenärzte"

Berlin, State of Berlin, 10961, Germany
Pneumologisches Studienzentrum Muenchen West

Munich, Bavaria, 81241, Germany
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny

Bialystok, 15-430, Poland
Prywatny Gabinet Internistyczno-Alergologiczny

Bialystok, 15-010, Poland
Recherche GCP Research

Montreal, Quebec, H1Y 3H5, Canada
Remington-Davis, Inc.

Columbus, Ohio, 43215, United States
So Cal Clinical Research

Huntington Beach, California, 92647, United States
South Texas Allergy & Asthma Medical Professionals

San Antonio, Texas, 78229, United States
Southeastern Research Center LLC

Winston-Salem, North Carolina, 27103, United States
St Josephs Physicians Med PC Pulmonary Health

Liverpool, New York, 13088, United States
Suburban Research Associates

West Chester, Pennsylvania, 19380, United States
Suncoast Research Group, LLC Miami - Little Havana dba Flourish Research

Miami, Florida, 33135, United States
Sundance Clinical Research

St Louis, Missouri, 63141, United States
TPMG Clinical Research Williamsburg

Williamsburg, Virginia, 23188, United States
The Clinical Research Center, LLC

St Louis, Missouri, 63141, United States
The Curators of the University of Missouri on behalf of University of Missouri Health Care

Columbia, Missouri, 65212, United States
The Iowa Clinic, PC

West Des Moines, Iowa, 50266, United States
The Valley Hospital

Paramus, New Jersey, 07652, United States
UZ Leuven

Leuven, 3000, Belgium
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of South Florida - PARENT

Tampa, Florida, 33613, United States
Velocity Research Germany GmbH

Lübeck, Schleswig-Holstein, 23552, Germany
Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma, 74136, United States
Well Pharma Medical Research Corporation

Miami, Florida, 33173, United States
West Walk Surgery

Bristol, Bristol, BS374AX, United Kingdom
Wythenshawe Hospital

Wythenshawe, Greater Manchester, M23 9LT, United Kingdom
Zentrum fuer ambulante pneumologische Forschung Marburg GbR

Marburg, Hesse, 35037, Germany