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New inhaler aims to quiet chronic cough

NCT ID NCT06504446

Symptom relief Sponsor: Nocion Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental inhaler called taplucainium (NOC-110) in 455 adults with chronic cough that has lasted at least a year and hasn't been helped by other treatments. Participants will take the inhaler or a placebo once daily for several weeks. The main goal is to see if the drug reduces the number of coughs per hour.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
taplucainium inhalation powder
What this could lead to
If it works, this could provide a new treatment option to reduce coughing in people with chronic cough that hasn't responded to other therapies.
What could go wrong
This is a mid-stage trial, so results are not yet proven. The drug may not reduce coughs significantly or could have side effects. It's also only for a specific type of chronic cough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 455 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Refractory or unexplained chronic cough for ≥ 12 months. * Women of childbearing potential agree to follow the protocol specified contraceptive - guidance during the study. * Males who are not vasectomized must agree to use the contraceptive methods defined in the protocol. * Able to provide Informed Consent. Exclusion Criteria: * Previous exposure to taplucainium (formerly NTX-1175) or known allergy or hypersensitivity to taplucainium, its excipients/metabolites, or related compounds. * Participants who are currently participating in another drug or device clinical study * Participants who have participated in an Acute or Chronic Cough investigational study within 60 days before the start of the Screening. * Current diagnosis of chronic obstructive pulmonary disease, bronchiectasis, unexplained pulmonary fibrosis, hemoptysis, bronchial asthma, or other pulmonary disease. * Respiratory tract infection within 4 weeks of Screening or during screening period. * Any female who is pregnant or lactating or wishing to become pregnant. * Donation of \> 1 Unit (450 milliliter or more) of blood within 60 days prior to the first dosing. * Alcohol or drug use disorder within the past 2 years. * Current smoker/vaper or individuals who have given up smoking within the past 6 months of screening, and/or those with \>20 pack-year smoking history. * Current opiate/opioid use or medical history of opiate/opioid use disorder. * History of concurrent malignancy or recurrence of malignancy in the last 2 years. * Body Mass Index of ≥40 kg/m2. * Positive results for human immunodeficiency virus, hepatitis B, or hepatitis C virus. * Unable to refrain from the use of medications and treatments that can impact cough during the study. * Have clinically significant history or evidence of poorly controlled cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, immunological, or psychiatric disorder(s).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Refractory or unexplained chronic cough

Contacts and locations

Locations

  • AMR Las Vegas

    Las Vegas, Nevada, 89119, United States

  • AMR Phoenix

    Tempe, Arizona, 85281, United States

  • AZ Delta

    Roeselare, 8800, Belgium

  • AZ Sint-Maarten

    Mechelen, 2800, Belgium

  • Accellacare

    Winston-Salem, North Carolina, 27103, United States

  • Accellacare

    Mt. Pleasant, South Carolina, 29464, United States

  • Accellacare d/b/a Accellacare of Knoxville

    Knoxville, Tennessee, 37938, United States

  • Accellacare of McFarland Clinic

    Ames, Iowa, 50010, United States

  • Aeroallergy Research Laboratories of Savannah, Inc.

    Savannah, Georgia, 31406, United States

  • Alamo ENT Associates

    San Antonio, Texas, 78258, United States

  • Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. Z .O.O.

    Tarnów, 33-100, Poland

  • Allergy & Asthma Associates of Santa Clara Valley

    San Jose, California, 95117, United States

  • Allergy & Asthma Specialists, PSC

    Owensboro, Kentucky, 42301, United States

  • Allergy Partners Clinical Research

    Asheville, North Carolina, 28803, United States

  • Allergy Partners of New Jersey P C

    Ocean City, New Jersey, 07712, United States

  • Allergy and Asthma Associates of Southern California dba Southern California Research

    Laguna Niguel, California, 92677, United States

  • Allergy and Asthma Clinical Research Inc

    Walnut Creek, California, 94598, United States

  • Allergy, Asthma & Sinus Center, SC

    Greenfield, Wisconsin, 53228, United States

  • Allergy, Asthma, and Immunology Medical Group

    Ventura, California, 93003, United States

  • BLC Clinical Research

    Burlington, Ontario, L7N 3V2, Canada

  • Belfast City Hospital

    Belfast, Belfast, BT9 7AB, United Kingdom

  • Bluegrass Allergy Research

    Lexington, Kentucky, 40509, United States

  • California Allergy & Asthma Medical Group Inc.

    San Jose, California, 95117, United States

  • Care Access Research - Warwick 1

    Warwick, Rhode Island, 02886, United States

  • Castle Hill Hospital

    Cottingham, East Riding of Yorkshire, HU16 5JQ, United Kingdom

  • Center for Clinical Trials, LLC

    Paramount, California, 90723, United States

  • Centrum Medyczne Lucyna Andrzej Dymek s.c.

    Strzelce Opolskie, 47-100, Poland

  • Centrum Medyczne Pratia Bydgoszcz

    Bydgoszcz, 85-796, Poland

  • Centrum Medyczne Pratia Czestochowa

    Częstochowa, 42-217, Poland

  • Clinical Research Institute

    Minneapolis, Minnesota, 55402, United States

  • Clinical Research of Gastonia

    Gastonia, North Carolina, 28054, United States

  • Clinical Research of Rock Hill

    Rock Hill, South Carolina, 29732, United States

  • Clinical Site Partners, LLC Leesburg dba Flourish Research

    Leesburg, Florida, 34748, United States

  • Clinical Site Partners, LLC Orlando dba Flourish Research

    Winter Park, Florida, 32789, United States

  • Clinique Specialisee en Allergie de la Capitale

    Québec, Quebec, G1V 4W2, Canada

  • Clinique de pneumologie et du sommeil de Lanaudière

    Saint-Charles-Borromée, Quebec, J6E 2B4, Canada

  • Continental Clinical Solutions, LLC

    Towson, Maryland, 21204, United States

  • DIEX Recherche Quebec Inc.

    Québec, Quebec, G1V 4T3, Canada

  • DIEX Recherche Sherbrooke Inc.

    Sherbrooke, Quebec, J1L 0H8, Canada

  • DIEX Recherche Victoriaville Inc.

    Victoriaville, Quebec, G6P 3Z8, Canada

  • DaVinci Research LLC.

    Roseville, California, 95661, United States

  • Duly Health and Care

    Winfield, Illinois, 60190, United States

  • Dynamic Drug Advancement

    Ajax, Ontario, L1S 2J5, Canada

  • Equity Medical LLC

    New York, New York, 10023, United States

  • G & L Research, LLC

    Foley, Alabama, 36535, United States

  • Gabinet Pulmonologii i Diagnostyki Chorób Alergicznych Dorota Maria Małosek

    Szczecin, 70-1111, Poland

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Infinity Medical Research Inc

    Russells Mills, Massachusetts, 02747, United States

  • Innovative Research of West Florida, Inc.

    Clearwater, Florida, 33756, United States

  • Inspiration Research Limited

    Toronto, Ontario, M5T 3A9, Canada

  • Internal Medicine and Pediatric Associates of Bristol, PC

    Bristol, Tennessee, 37620, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • King's College Hospital

    London, Greater London, SE5 9RS, United Kingdom

  • Little Rock Allergy & Asthma, P.A. Clinical Research Center

    Little Rock, Arkansas, 72205, United States

  • Lowcountry Lung and Critical Care, P.A.

    Charleston, South Carolina, 29406, United States

  • Lungenzentrum Darmstadt

    Darmstadt, Hesse, 64283, Germany

  • Lynn Health Science Institute

    Oklahoma City, Oklahoma, 73112, United States

  • Lynn Institute of Denver

    Aurora, Colorado, 80012, United States

  • M3 Wake Research, Inc.

    Raleigh, North Carolina, 27612, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, 55905, United States

  • McMaster University

    Hamilton, Ontario, L8N 3Z5, Canada

  • Medaimun GmbH

    Frankfurt am Main, Hesse, 60596, Germany

  • Medical Research of Arizona

    Scottsdale, Arizona, 85251, United States

  • Midwest Chest Consultants

    Saint Charles, Missouri, 63301, United States

  • Montana Medical Research, Inc.

    Missoula, Montana, 59808, United States

  • NewportNativeMD,Inc

    Newport Beach, California, 92663, United States

  • North Tyneside General Hospital

    North Shields, Tyne & Wear, NE29 8NH, United Kingdom

  • Northwest Research Center

    Portland, Oregon, 97202, United States

  • Nottingham City Hospital

    Nottingham, Nottinghamshire, NG56EG, United Kingdom

  • Omega Research Debary, LLC

    DeBary, Florida, 32713, United States

  • Ormeau Clinical Trials Ltd

    Belfast, Belfast, BT2 8BG, United Kingdom

  • Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

    Ostrowiec Świętokrzyski, 27-400, Poland

  • Paradigm Clinical Research Centers, LLC

    Redding, California, 96001, United States

  • Paradigm Clinical Research Centers, LLC - Modesto

    Modesto, California, 95355, United States

  • Pharmaceutical Research & Consulting, Inc.

    Dallas, Texas, 75231, United States

  • Pneumocare

    Namur, 5380, Belgium

  • Pneumologicum Halle

    Halle, Saxony-Anhalt, 06108, Germany

  • Pneumologisches Forschungsinstitut Hohegeest GbR

    Geesthacht, Schleswig-Holstein, Germany

  • Pneumologisches Studienzentrum MVZ "Die Lungenärzte"

    Berlin, State of Berlin, 10961, Germany

  • Pneumologisches Studienzentrum Muenchen West

    Munich, Bavaria, 81241, Germany

  • Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny

    Bialystok, 15-430, Poland

  • Prywatny Gabinet Internistyczno-Alergologiczny

    Bialystok, 15-010, Poland

  • Recherche GCP Research

    Montreal, Quebec, H1Y 3H5, Canada

  • Remington-Davis, Inc.

    Columbus, Ohio, 43215, United States

  • So Cal Clinical Research

    Huntington Beach, California, 92647, United States

  • South Texas Allergy & Asthma Medical Professionals

    San Antonio, Texas, 78229, United States

  • Southeastern Research Center LLC

    Winston-Salem, North Carolina, 27103, United States

  • St Josephs Physicians Med PC Pulmonary Health

    Liverpool, New York, 13088, United States

  • Suburban Research Associates

    West Chester, Pennsylvania, 19380, United States

  • Suncoast Research Group, LLC Miami - Little Havana dba Flourish Research

    Miami, Florida, 33135, United States

  • Sundance Clinical Research

    St Louis, Missouri, 63141, United States

  • TPMG Clinical Research Williamsburg

    Williamsburg, Virginia, 23188, United States

  • The Clinical Research Center, LLC

    St Louis, Missouri, 63141, United States

  • The Curators of the University of Missouri on behalf of University of Missouri Health Care

    Columbia, Missouri, 65212, United States

  • The Iowa Clinic, PC

    West Des Moines, Iowa, 50266, United States

  • The Valley Hospital

    Paramus, New Jersey, 07652, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of South Florida - PARENT

    Tampa, Florida, 33613, United States

  • Velocity Research Germany GmbH

    Lübeck, Schleswig-Holstein, 23552, Germany

  • Vital Prospects Clinical Research Institute, P.C.

    Tulsa, Oklahoma, 74136, United States

  • Well Pharma Medical Research Corporation

    Miami, Florida, 33173, United States

  • West Walk Surgery

    Bristol, Bristol, BS374AX, United Kingdom

  • Wythenshawe Hospital

    Wythenshawe, Greater Manchester, M23 9LT, United Kingdom

  • Zentrum fuer ambulante pneumologische Forschung Marburg GbR

    Marburg, Hesse, 35037, Germany