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Could a headset boost brainpower in teens with a rare genetic condition?

NCT ID NCT05664412

Recruiting now Symptom relief Sponsor: Stephan Eliez Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a gentle brain stimulation technique called tACS, used at home for 5 days a week over 4 weeks, can improve memory and thinking in 40 young people aged 14-25 with 22q11.2 deletion syndrome. The stimulation is personalized based on each participant's MRI and EEG results. The main goal is to check safety and tolerability, with a secondary focus on whether it helps working memory.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transcranial alternating current stimulation (tACS) via a home device
What this could lead to
If it works, this could offer a safe, at-home way to boost memory and thinking skills in young people with 22q11.2 deletion syndrome, potentially delaying or preventing later psychotic symptoms.
What could go wrong
This is a small, early-stage trial (40 people) focused mainly on safety. The cognitive benefits are unproven, and the stimulation may cause mild side effects like headache or tingling. Results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

22q11 Deletion Syndrome 22q11.2 deletion syndrome persistent truncus arteriosus velocardiofacial syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

22Q11 DELETION SYNDROME TACS

Contacts and locations

Locations

  • University of Geneva

    RECRUITING

    Geneva, Canton of Geneva, 1200, Switzerland

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