Toothpaste aimed at treating chronic mouth sores in transplant patients shows early promise
NCT ID NCT06638879
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study tested a special toothpaste containing tacrolimus in 7 patients with oral chronic graft vs. host disease (cGVHD) after a stem cell transplant. Participants used the toothpaste twice daily for three months alongside their usual medications. The goal was to see if it could help manage painful mouth ulcers and gather information for future larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tacrolimus toothpaste
What this could lead to
If this works, it could offer a new topical option to manage painful mouth sores from chronic graft vs. host disease after a stem cell transplant.
What could go wrong
This is a very early Phase 1 study with only 7 participants, so results may not apply to everyone. It is not a cure and is meant only as an add-on to standard therapy.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States