Steroid showdown: trial aims to perfect rejection treatment for kidney transplants
NCT ID NCT06474273
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
After a kidney or kidney-pancreas transplant, the body may attack the new organ—a problem called acute T cell mediated rejection. Doctors use strong steroids to stop this, but there's no standard dose, and too much can cause serious side effects. This phase 3 trial will enroll 540 participants to compare different steroid doses, aiming to find the safest and most effective approach to treat rejection and protect the transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methylprednisolone and prednisone (steroids)
What this could lead to
If successful, this study could establish a standard, safer steroid dosing regimen for treating acute rejection in kidney and kidney-pancreas transplant recipients, reducing side effects while preserving organ function.
What could go wrong
This is a phase 3 trial, but it focuses on optimizing an existing treatment rather than a new breakthrough. The optimal dose may still carry significant side effects, and results may not apply to all patient groups.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Auckland City Hospital
NOT_YET_RECRUITINGGrafton, Auckland, 1023, New Zealand
Contact
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Dalhousie University
NOT_YET_RECRUITINGHalifax, Nova Scotia, B3H 4R2, Canada
Contact
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John Hunter Hospital
NOT_YET_RECRUITINGLambton, New South Wales, 2305, Australia
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McGill University
NOT_YET_RECRUITINGMontreal, Quebec, H3A 0G4, Canada
Contact
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Monash Medical Centre
NOT_YET_RECRUITINGClayton, Victoria, 3168, Australia
Contact
Contact
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Prince of Wales Hospital
NOT_YET_RECRUITINGRandwick, New South Wales, 2031, Australia
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Princess Alexandra Hospital
NOT_YET_RECRUITINGWoolloongabba, Queensland, 4102, Australia
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, 2014, Australia
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Royal Adelaide Hospital
NOT_YET_RECRUITINGAdelaide, South Australia, 5000, Australia
Contact
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Royal Perth Children's hospital
NOT_YET_RECRUITINGNedlands, Western Australia, 6009, Australia
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Royal Perth Hospital
NOT_YET_RECRUITINGPerth, Western Australia, 6000, Australia
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Sir Charles Gairdner Hospital
NOT_YET_RECRUITINGNedlands, Western Australia, 6009, Australia
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The Sydney Children's Hospital Network
NOT_YET_RECRUITINGWestmead, New South Wales, 2145, Australia
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Transplant Manitoba, adult
NOT_YET_RECRUITINGWinnipeg, Manitoba, R3A 1R9, Canada
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Transplant Manitoba, pediatric
NOT_YET_RECRUITINGWinnipeg, Manitoba, R3A 1R9, Canada
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University of Alberta
NOT_YET_RECRUITINGEdmonton, Alberta, T6G 2R3, Canada
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University of Calgary
NOT_YET_RECRUITINGCalgary, Alberta, T2N 1N4, Canada
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University of Laval
NOT_YET_RECRUITINGQuébec, Quebec, G1V 0B4, Canada
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University of Montreal
NOT_YET_RECRUITINGMontreal, Quebec, H3T 1J4, Canada
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University of Saskatchewan
NOT_YET_RECRUITINGSaskatoon, Saskatchewan, S7N 5A2, Canada
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University of Toronto
NOT_YET_RECRUITINGToronto, Ontario, M5S 1A1, Canada
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University of Toronto - Hospital for Sick Kids
NOT_YET_RECRUITINGToronto, Ontario, M5G 1E8, Canada
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University of Toronto - St Michael Hospital
NOT_YET_RECRUITINGToronto, Ontario, M5B 1W8, Canada
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Western University
NOT_YET_RECRUITINGLondon, Ontario, N6A 3K7, Canada
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
Contact