Steroid showdown: trial aims to perfect rejection treatment for kidney transplants

NCT ID NCT06474273

Recruiting now Disease control Sponsor: University of Sydney Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

After a kidney or kidney-pancreas transplant, the body may attack the new organ—a problem called acute T cell mediated rejection. Doctors use strong steroids to stop this, but there's no standard dose, and too much can cause serious side effects. This phase 3 trial will enroll 540 participants to compare different steroid doses, aiming to find the safest and most effective approach to treat rejection and protect the transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methylprednisolone and prednisone (steroids)
What this could lead to: If successful, this study could establish a standard, safer steroid dosing regimen for treating acute rejection in kidney and kidney-pancreas transplant recipients, reducing side effects while preserving organ function.
What could go wrong: This is a phase 3 trial, but it focuses on optimizing an existing treatment rather than a new breakthrough. The optimal dose may still carry significant side effects, and results may not apply to all patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute transplant rejection Rejection, Psychology transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REJECTION; TRANSPLANT, KIDNEY REJECTION; TRANSPLANT, PANCREAS

Contacts and locations

Locations

Auckland City Hospital
NOT_YET_RECRUITING

Grafton, Auckland, 1023, New Zealand
Dalhousie University
NOT_YET_RECRUITING

Halifax, Nova Scotia, B3H 4R2, Canada
John Hunter Hospital
NOT_YET_RECRUITING

Lambton, New South Wales, 2305, Australia
McGill University
NOT_YET_RECRUITING

Montreal, Quebec, H3A 0G4, Canada
Monash Medical Centre
NOT_YET_RECRUITING

Clayton, Victoria, 3168, Australia
Prince of Wales Hospital
NOT_YET_RECRUITING

Randwick, New South Wales, 2031, Australia
Princess Alexandra Hospital
NOT_YET_RECRUITING

Woolloongabba, Queensland, 4102, Australia
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 2014, Australia
Royal Adelaide Hospital
NOT_YET_RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Perth Children's hospital
NOT_YET_RECRUITING

Nedlands, Western Australia, 6009, Australia
Royal Perth Hospital
NOT_YET_RECRUITING

Perth, Western Australia, 6000, Australia
Sir Charles Gairdner Hospital
NOT_YET_RECRUITING

Nedlands, Western Australia, 6009, Australia
The Sydney Children's Hospital Network
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Transplant Manitoba, adult
NOT_YET_RECRUITING

Winnipeg, Manitoba, R3A 1R9, Canada
Transplant Manitoba, pediatric
NOT_YET_RECRUITING

Winnipeg, Manitoba, R3A 1R9, Canada
University of Alberta
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 2R3, Canada
University of Calgary
NOT_YET_RECRUITING

Calgary, Alberta, T2N 1N4, Canada
University of Laval
NOT_YET_RECRUITING

Québec, Quebec, G1V 0B4, Canada
University of Montreal
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1J4, Canada
University of Saskatchewan
NOT_YET_RECRUITING

Saskatoon, Saskatchewan, S7N 5A2, Canada
University of Toronto
NOT_YET_RECRUITING

Toronto, Ontario, M5S 1A1, Canada
University of Toronto - Hospital for Sick Kids
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1E8, Canada
University of Toronto - St Michael Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Western University
NOT_YET_RECRUITING

London, Ontario, N6A 3K7, Canada
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia