New eye drug aims to restore vision in Inflammation-Related swelling

NCT ID NCT06990399

Recruiting now Disease control Sponsor: Kodiak Sciences Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests an experimental drug called tabirafusp alfa (KSI-101) given as an eye injection for people with macular edema (swelling) caused by inflammation. The study will compare the drug to a sham (fake) injection in 600 participants to see if it improves vision and reduces swelling over 24 weeks. The goal is to find a safe and effective treatment for this vision-threatening condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tabirafusp alfa (KSI-101)
What this could lead to: If it works, this could offer a new treatment option for people with vision loss due to inflammation-related macular edema.
What could go wrong: This is a late-stage trial, but the drug is still experimental. It may not improve vision better than sham injections, and eye injections carry risks like infection or inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Macular Edema macular retinal edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MACULAR EDEMA SECONDARY TO INFLAMMATION

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AZ Retina & Vitreous Consultants
RECRUITING

Phoenix, Arizona, 85016, United States
Associated Vitreoretinal and Uveitis Consultants LLC
RECRUITING

Carmel, Indiana, 46032, United States
Austin Retina Associates, PLLC (Austin)
RECRUITING

Austin, Texas, 78705, United States
Austin Retina Associates, PLLC (Round Rock)
RECRUITING

Round Rock, Texas, 78681, United States
California Eye Specialists Medical Group, Inc.
RECRUITING

Pasadena, California, 91107, United States
California Eye Specialists Medical Group, Inc.
RECRUITING

Redlands, California, 92373, United States
California Retina Consultants (Bakersfield)
RECRUITING

Bakersfield, California, 93309, United States
California Retina Consultants (Oxnard)
RECRUITING

Oxnard, California, 93036, United States
Cascade Medical Research Institute
RECRUITING

Springfield, Oregon, 97477, United States
Centro Oftalmologico Metropolitano
RECRUITING

San Juan, 00921, Puerto Rico
Charleston Neuroscience Institute, LLC (Charleston)
RECRUITING

Charleston, South Carolina, 29414, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Coastal Eye Surgeons
RECRUITING

Greenwich, Connecticut, 06830, United States
Cumberland Valley Retina Consultants
RECRUITING

Hagerstown, Maryland, 21740, United States
Erie Retina Research
RECRUITING

Erie, Pennsylvania, 16507, United States
Eye Associates of New Mexico, Vision Research Center
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87109, United States
Eye Clinic of Wisconsin
RECRUITING

Wausau, Wisconsin, 54403, United States
Florida Eye Clinic
NOT_YET_RECRUITING

Altamonte Springs, Florida, 32701, United States
Global Research Management, Inc.
RECRUITING

Glendale, California, 91204, United States
Midwest Eye Institute
RECRUITING

Carmel, Indiana, 46032, United States
North Carolina Retina Associates (Cary)
RECRUITING

Cary, North Carolina, 27511, United States
North Carolina Retina Associates (Wake Forest)
RECRUITING

Wake Forest, North Carolina, 27587, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43212, United States
Ophthalmic Consultants of Boston
RECRUITING

Boston, Massachusetts, 02114, United States
Ophthalmology Ltd
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Pacific Northwest Retina (Bellevue)
RECRUITING

Bellevue, Washington, 98004, United States
Pacific Northwest Retina (Silverdale)
RECRUITING

Silverdale, Washington, 98383, United States
Palmetto Retina Center (West Columbia)
RECRUITING

West Columbia, South Carolina, 29169, United States
Research Network Arizona
RECRUITING

Scottsdale, Arizona, 85255, United States
Retina Associates of New York, P.C.
RECRUITING

New York, New York, 10075, United States
Retina Associates, LTD
RECRUITING

Elmhurst, Illinois, 60126, United States
Retina Consultants of Minnesota
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Retina Consultants of Southern California
RECRUITING

Redlands, California, 92374, United States
Retina Consultants of Texas (Bellaire)
RECRUITING

Bellaire, Texas, 77401, United States
Retina Consultants of Texas (Katy)
RECRUITING

Katy, Texas, 77494, United States
Retina Consultants of Texas (San Antonio)
RECRUITING

San Antonio, Texas, 78240, United States
Retina Consultants of Texas (Woodlands)
RECRUITING

The Woodlands, Texas, 77384, United States
Retina Consultants, PC
RECRUITING

Manchester, Connecticut, 06042, United States
Retina Group of Florida (Ft. Lauderdale)
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Retina Group of New England, PC
RECRUITING

Waterford, Connecticut, 06385, United States
Retina Research Institute of Texas
RECRUITING

Abilene, Texas, 70606, United States
Retina Specialists of Colorado (RSC)
WITHDRAWN

Denver, Colorado, 80222, United States
Retina Vitreous Associates of Florida (St. Petersburg)
RECRUITING

St. Petersburg, Florida, 33711, United States
Retinal Consultants Medical Group Inc
RECRUITING

Sacramento, California, 95841, United States
Rocky Mountain Uveitis
RECRUITING

Denver, Colorado, 80246, United States
St. Mary's Eye Surgery Center (Metropolitan Eye Research and Surgery Institute)
RECRUITING

Palisades Park, New Jersey, 07650, United States
Stanford Byers Eye Institute
NOT_YET_RECRUITING

Palo Alto, California, 94303, United States
Tennessee Retina PC
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associates (Plano)
RECRUITING

Plano, Texas, 75075, United States
Texas Retina Center
RECRUITING

Houston, Texas, 77030, United States
The Retina Institute
RECRUITING

St Louis, Missouri, 63128, United States
UCLA Stein Eye Institute
RECRUITING

Los Angeles, California, 90095, United States
UCSD/Jacobs Retina Center
RECRUITING

La Jolla, California, 92093, United States
UT Austin
NOT_YET_RECRUITING

Austin, Texas, 78712, United States
Vanderbilt Eye Institute
RECRUITING

Nashville, Tennessee, 37232, United States
Vision Research Solutions
WITHDRAWN

Philadelphia, Pennsylvania, 19141, United States

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New eye drug aims to restore vision in inflammatory swelling