New hope for hard-to-treat lymphoma: drug combo aims to keep cancer at bay

NCT ID NCT04224493

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This study is for people with follicular lymphoma, a type of blood cancer, that has returned or no longer responds to treatment. It tests whether adding the drug tazemetostat to a standard two-drug combination can help patients live longer without their cancer getting worse. About 555 adults will take part, and the study compares the new combo to a placebo plus the standard drugs.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for REFRACTORY FOLLICULAR LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • AOU Careggi

    Florence, 50134, Italy

  • AOU Federico II

    Naples, Campania, 80122, Italy

  • ASST Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Ajou University Hospital

    Suwon, South Korea

  • Ankara University Medical Faculty - Hematology

    Ankara, Turkey (Türkiye)

  • Arizona Oncology Associates - Tuscon-Rusadill Road

    Tucson, Arizona, 85704, United States

  • Association Hospital de Caridade de Iju

    Ijuí, Brazil

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Astera Cancer Center

    East Brunswick, New Jersey, 08816, United States

  • Azienda Ospedaliera Ordine Mauriziano di Torino, Ospedale Umberto I di Torino

    Torino, Italy

  • Azienda Ospedaliera Santa Maria di Terni

    Terni, 05100, Italy

  • Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI), Ospedale Maggiore

    Trieste, Italy

  • BRCR Medical Center, INC

    Plantation, Florida, 33322, United States

  • Barwon Health, University Hospital Geelong

    Geelong, Victoria, 3220, Australia

  • Beatson West of Scotland Cancer Centre

    Glasgow, G12 0YN, United Kingdom

  • Buddihist Tzu Chi Medical Foundation- Hualien Tzu Chi Hospital

    Hualien City, Taiwan

  • C.H. de Navarra

    Pamplona, Spain

  • CHRU Brest Hôp Morvan

    Brest, Brittany Region, 29609, France

  • CHRU de Besançon- Hopital Jean Minjoz

    Besançon, 25000, France

  • CHRU de Lille Hop Claude Huriez

    Lille, Nord, 59037, France

  • CHU de Clermont-Ferrand, site Estaing

    Clermont-Ferrand, 63000, France

  • CHU de Grenoble - Hopital Albe

    La Tronche, Isere, 38700, France

  • CHU de Limoges Dupuytren

    Limoges, Haute-Vienne, 87042, France

  • CHU de Nancy Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU de Nantes - Hematologie

    Nantes, Loire-Atlantique, 44000, France

  • Cancer Specialists of North Florida

    Fleming Island, Florida, 32003, United States

  • Catholic University Of Sacred Heart

    Roma, 00168, Italy

  • Centre Henri Becquerel

    Rouen, Haute-Normandie, 76038, France

  • Centre Hosp Mulh Hop Emile Muller

    Mulhouse, Haut-Rhin, 68100, France

  • Centre Hospitalier - Hôpital de jour d'Hématologie

    Périgueux, France

  • Centre Hospitalier Bretagne Atlantique

    Vannes, 56017, France

  • Centre Hospitalier Docteur Schaffner

    Lens, France

  • Centre Hospitalier Le Mans

    Le Mans, Sarthe, 72000, France

  • Centre Hospitalier Universitaire D'Angers - Hématologie Clinique

    Angers, France

  • Centre Hospitalier Universitaire de Bordeaux-Hopital du Haut Leveque

    Pessac, Aquitaine, 33600, France

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, France

  • Centre Hospitalier de l'Universite de Montreal (CHUM)

    Montreal, Quebec, H2X 3E4, Canada

  • Centrum Medyczne Pratia Poznan

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

  • Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology

    Kaohsiung City, 833, Taiwan

  • Clínica Universidad de Navarra

    Madrid, Spain

  • Columbia U - Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • Debreceni Egyetem Klinikai Központ

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Diakoneo Diak Schwaebisch Hall gGmbH

    Schwäbisch Hall, Baden-Wurttemberg, 74523, Germany

  • Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research

    Ankara, Turkey (Türkiye)

  • FirstHealth of the Carolinas

    Pinehurst, North Carolina, 28374, United States

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Florida Cancer Affiliates/Ocala Oncology - Clinic

    Ocala, Florida, 34474, United States

  • Florida Cancer Specialists

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists & Research Institute (FCS) - Atlantis

    West Palm Beach, Florida, 33401, United States

  • Florida Cancer Specialists & Research Institute (FCS) - Fort Myers Cancer Center

    Fort Myers, Florida, 33908, United States

  • Florida Cancer Specialists - Panhandle

    Tallahassee, Florida, 32308, United States

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

  • Fundacao Antonio Prudente - Hospital A.C.Camargo Cancer Center

    São Paulo, Brazil

  • Gabrail Cancer Center Research

    Canton, Ohio, 44718, United States

  • Gachon University Gil Medical Center

    Incheon, South Korea

  • Gazi University Medical Faculty

    Ankara, Turkey (Türkiye)

  • GenesisCare - St Andrew's

    Adelaide, Australia

  • Gold Coast University Hosptial

    Southport, Australia

  • H Lee Moffitt Cancer Center and Research Institute I

    Tampa, Florida, 33612, United States

  • HC-UFG - Hospital das CLINICAS da Universidade Federal de Go

    Goiânia, Brazil

  • Hematology Oncology Associates of Rockland, P.C.

    Nyack, New York, 10960, United States

  • Henan Cancer Hospital

    Zhengzhou, Henan, 45008, China

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450008, China

  • Hollywood Private Hospital

    Nedlands, Western Australia, 6009, Australia

  • Hopital Henri Mondor - Hemopathies Lymphoides

    Créteil, Île-de-France Region, 94010, France

  • Hopital Saint Louis

    Paris, 75010, France

  • Hospital Alemao Oswaldo Cruz (HAOC)

    São Paulo, Brazil

  • Hospital Costa del Sol

    Marbella, Málaga, 29603, Spain

  • Hospital Del Mar

    Barcelona, 08003, Spain

  • Hospital Haroldo Juacaba - Instituto do Cancer do Ceara

    Ceará, Brazil

  • Hospital Santa Cruz

    Curitiba, Brazil

  • Hospital Univ. Infanta Leonor

    Madrid, 28031, Spain

  • Hospital Universitari Vall d'Hebrón

    Barcelona, Cataluny, 08035, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Nuestra Señora de Valme

    Seville, 41014, Spain

  • Hospital Universitario Virgen De La Macarena

    Seville, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital Virgen de la Arrixaca

    El Palmar, Spain

  • Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica

    Porto Alegre, Brazil

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013, China

  • Huntsman Cancer Institute; The University of Utah

    Salt Lake City, Utah, 84112, United States

  • IEO - Istituto Europeo di Oncologia, IRCCS

    Milan, Italy

  • Illinois Cancer Specialists

    Niles, Illinois, 60714, United States

  • Imperial College Healthcare NHS Trust - Hammersmith Hospital

    London, London City, W12 0HS, United Kingdom

  • Institut Bergonie

    Bordeaux, Gironde, 33000, France

  • Institut Gustave Roussy

    Villejuif, France

  • Instituto D'Or de Pesquisa e Ensino- Recife

    Recife, Brazil

  • Instituto D'or de Pesquisa e Ensino

    São Paulo, Brazil

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, Brazil

  • Instituto de Oncologia e Hematologia - HEMOMED

    São Paulo, Brazil

  • Instituto de Psiquiatria - UFRJ

    Rio de Janeiro, Brazil

  • Irmandade Santa Casa de Misericordia de Sao Paulo

    São Paulo, Brazil

  • Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori IRCCS

    Meldola, Forli-Cesena, 47014, Italy

  • Jiangxi Cancer Hospital

    Nanchang, China

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, North Rhine-Westphalia, 41063, Germany

  • Klinikum Der Universität München AöR

    München, Bavaria, 81377, Germany

  • L'Hôpital Privé Confluent

    Nantes, 44202, France

  • L'hôpital Privé du Concluent

    Nantes, France

  • Levine Cancer Institute - Concord

    Concord, North Carolina, 28205, United States

  • Liga Norte Riograndense Contra o Cancer

    Natal, Brazil

  • MICS Centrum Medyczne Torun

    Torun, 87-100, Poland

  • MTZ Clinical Research powered by Pratia

    Warsaw, Poland

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, 55901, United States

  • Mays Cancer Center

    San Antonio, Texas, 78229, United States

  • Medipol Bagcilar Mega Hospital

    Istanbul, Turkey (Türkiye)

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • Messino Cancer Center

    Asheville, North Carolina, 28806, United States

  • Millennium Physicians - Oncology

    Houston, Texas, 77090, United States

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Center Singapore

    Singapore, Singapore

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • New Mexico Cancer Care Alliance

    Albuquerque, New Mexico, 87131-0001, United States

  • Northwick Park Hospital Middlesex, United Kindgom, HA1 3UJ

    Middlesex, United Kingdom

  • Nova Scotia Health Centre for Clinical Research

    Nova Scotia, Canada

  • Oncology Hematology Care (OHC), Inc. - Kenwood Office

    Cincinnati, Ohio, 45236, United States

  • Oncology and Hematology Associates of Southwest Virginia Inc.

    Roanoke, Virginia, 24014, United States

  • Ondokuz Mayis University Medical Faculty - Hematology

    Samsun, Turkey (Türkiye)

  • Országos Onkológiai Intézet

    Budapest, 1122, Hungary

  • Ospedale Civile S.Spirito, PO di Pescara, AUSL Pescara

    Pescara, Italy

  • Ospedale Infermi di Rimini, AUSL Rimini, Distretto di Rimini, Presidio di Rimini, Santarcangelo di Romagna e Novafeltria

    Rimini, Italy

  • Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda

    Milan, Italy

  • Ospedale Niguarda, ASST Grande Ospedale Metropolitano Niguarda

    Milan, Italy

  • Ospedale S.Giacomo Apostolo, PO Castelfranco Veneto, AULSS 2 Marca Trevigiana

    Treviso, Italy

  • Ospedale San Gerardo, ASST di Monza

    Monza, Italy

  • Ospedale Vito Fazzi, ASL Lecce

    Lecce, Italy

  • PO Garibaldi-Nesima, ARNAS Garibaldi

    Catania, 95122, Italy

  • PU Campus Bio-Medico di Roma

    Roma, Italy

  • Peking University Third Hospital

    Beijing, 100191, China

  • Peninsula Health - Frankston

    Frankston, Australia

  • Pratia MCM Krakow

    Krakow, 30-727, Poland

  • Pratia Onkologia Katowice

    Katowice, Poland

  • Pusan National University Hospital

    Busan, South Korea

  • Regina Elena, Istituto Nazionale dei Tumori , IFO, IRCCS

    Roma, Italy

  • Regional Cancer Care Associates LLC - Little Silver

    Little Silver, New Jersey, 07739, United States

  • Regional Cancer Care Associates-Freehold

    Freehold, New Jersey, 07728, United States

  • Regional Medical Oncology Center

    Wilson, North Carolina, 27895, United States

  • Rocky Mountain Cancer Centers (RMCC) - Boulder

    Boulder, Colorado, 80303, United States

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital

    Cornwell, United Kingdom

  • Royal Hobart Hospital

    Hobart, Australia

  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, Shanghai Municipality, 20025, China

  • Samsung Medical Center

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, 06351, South Korea

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Semmelweis Egyetem Általános Orvostudományi Kar

    Budapest, 1088, Hungary

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, 03722, South Korea

  • Shandong Cancer Hospital

    Shandong, China

  • Shanxi Bethune Hospital

    Taiyuan, Shanxi, 30032, China

  • Sichuan Provincial People's Hospital

    Sichuan, China

  • Sir Mortimer B Davis/Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Southern Cancer Center

    Mobile, Alabama, 36608, United States

  • St Bartholomew's Hospital Barts Health NHS Trust

    London, London, City of, EC1A 7BE, United Kingdom

  • St. Joseph Mercy Hospital

    Ypsilanti, Michigan, 48197, United States

  • St. Mary's Hospital and Regional Medical Center - St. Mary's

    Grand Junction, Colorado, 81501, United States

  • Städt. Krankenhaus Kiel

    Kiel, Schleswig-Holstein, 24116, Germany

  • Sunnybrook Health Sciences Centre Odette Cancer Centre

    Ottawa, Canada

  • TOI - Clinical Research

    Cerritos, California, 90703, United States

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Tan Tock Seng Hospital

    Singapore, Singapore

  • Texas Oncology

    Plano, Texas, 75075, United States

  • Texas Oncology - Amarillo

    Amarillo, Texas, 79124, United States

  • Texas Oncology - Medical City Dallas Pediatric Hematology

    Dallas, Texas, 75230, United States

  • Texas Oncology- Weslaco

    Weslaco, Texas, 78596, United States

  • Texas Oncology-Austin Midtown

    Austin, Texas, 78705, United States

  • Texas Oncology-Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou, 550004, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong, 266071, China

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukp], 06591, South Korea

  • The Clatterbridge Cancer Centre NHS Foundation Trust - Clatterbridge Cancer Centre

    Bebington, United Kingdom

  • The First Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, China

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian, 361003, China

  • The First Bethune Hospital of Jilin University

    Changchun, Jinlin, 130021, China

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050011, China

  • The Second Affiliated Hospital Zhejiang University School of Medicine

    Zhejiang, Hangzhou, 310000, China

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, 300060, China

  • Tongji Hospital of Tongji Medical College of HUST

    Hangzhou, China

  • Tongji Hospital of Tongji University

    Shanghai, China

  • UC San Diego Health Sciences

    La Jolla, California, 92093, United States

  • UCLA Clinical Research Unit Hematology/Oncology

    Santa Monica, California, 90404, United States

  • UCSF Fresno

    Clovis, California, 93611, United States

  • USO Texas Oncology - Tyler

    Tyler, Texas, 75702, United States

  • UT Health East Texas HOPE Cancer Center - Tyler

    Tyler, Texas, 75701, United States

  • UZ Leuven - Campus Gasthuisberg

    Leuven, Vlaams Brabant, 3000, Belgium

  • Universitaetsklinikum Bonn AöR

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitair Ziekenhuis Gent

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • University Health Network Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University Medical Center Schleswig Holstein

    Kiel, Germany

  • University Of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • Universitätsmedizin Mainz

    Mainz, Hesse, 55131, Germany

  • Uniwersytecki Szpital Kliniczny im. J. Mikulicza-Radeckiego we Wroclawiu

    Wroclaw, 50-367, Poland

  • Utah Cancer Specialists/ IHO Corp

    Salt Lake City, Utah, 84106, United States

  • Virginia Cancer Specialists

    Gainesville, Virginia, 22155, United States

  • Vivantes Klinikum am Urban Hämatologie und Onkologie

    Berlin, Germany

  • Weill Cornell Medicine-New York Presbyterian Hospital

    New York, New York, 10021, United States

  • Western General Hospital - Haematology

    Edinburgh, Edinburgh, City of, EH4 2XU, United Kingdom

  • Western Pennsylvania Hospital Hematology & Cellular Therapy

    Pittsburgh, Pennsylvania, 15524, United States

  • Wheeling Hospital

    Wheeling, West Virginia, 26003, United States

  • Willamette Valley Cancer Institute and Research Center - Oncology

    Eugene, Oregon, 97401, United States

Conditions

Explore the condition pages connected to this study.