New drug SY-9453 targets Hard-to-Treat cancers in early trial
NCT ID NCT07469982
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study is testing a new oral drug, SY-9453, in 122 adults with advanced solid tumors that have a specific genetic deletion (MTAP). The main goals are to check safety, find the best dose, and get a first look at whether the drug can shrink tumors. Participants must have tried standard treatments without success or have no standard options left.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SY-9453 capsules
What this could lead to
If successful, this could point toward a new treatment option for people with advanced solid tumors that have a specific genetic deletion (MTAP).
What could go wrong
This is an early Phase 1 trial with only 122 participants, focused on safety and dosing. It is too soon to know if SY-9453 will be effective or have manageable side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shanghai East Hospital
RECRUITINGShanghai, China
Contact Email: •••••@•••••