Midlife Women's heart health: stress and sleep may be key
NCT ID NCT06745466
First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study looks at how daily stress, sleep patterns, and the hormone estrogen affect blood vessel health in women aged 40–55 who are still premenopausal. Researchers will temporarily lower estrogen in 30 volunteers using a drug called ganirelix to see how it changes blood vessel function. The goal is to understand why heart disease risk rises after menopause.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ganirelix acetate
- What this could lead to
- If successful, this could clarify how estrogen loss during menopause contributes to heart disease risk, pointing toward future prevention strategies.
- What could go wrong
- This is a small, early-stage mechanistic study (30 participants) that temporarily blocks hormones—it is not testing a treatment. Results may not apply to all women.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Delaware
RECRUITINGNewark, Delaware, 19713, United States
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