New RNA drug aims to stop painful swelling attacks in rare genetic disease
NCT ID NCT06960213
First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 27 times
Summary
This study tests an investigational drug called ADX-324 in 90 adults with hereditary angioedema (HAE) types 1 or 2. HAE causes sudden, painful swelling in the body. ADX-324 uses a technology called siRNA to lower a protein involved in triggering attacks. The goal is to see if the drug can reduce how often attacks happen compared to a placebo. Participants will receive injections and be monitored for safety and quality of life.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ADARx Clinical Site
RECRUITINGLitchfield Park, Arizona, 85340, United States
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ADARx Clinical Site
RECRUITINGLittle Rock, Arkansas, 72205, United States
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ADARx Clinical Site
RECRUITINGSan Diego, California, 92122, United States
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ADARx Clinical Site
RECRUITINGWalnut Creek, California, 94598, United States
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ADARx Clinical Site
RECRUITINGOrlando, Florida, 32807, United States
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ADARx Clinical Site
RECRUITINGChevy Chase, Maryland, 20815, United States
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ADARx Clinical Site
RECRUITINGWheaton, Maryland, 20902, United States
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ADARx Clinical Site
RECRUITINGDetroit, Michigan, 48202, United States
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ADARx Clinical Site
RECRUITINGSt Louis, Missouri, 63141, United States
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ADARx Clinical Site
RECRUITINGLas Vegas, Nevada, 89128, United States
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ADARx Clinical Site
RECRUITINGNew York, New York, 10029, United States
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ADARx Clinical Site
RECRUITINGCincinnati, Ohio, 45236, United States
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ADARx Clinical Site
RECRUITINGColumbus, Ohio, 43235, United States
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ADARx Clinical Site
RECRUITINGToledo, Ohio, 43617, United States
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ADARx Clinical Site
NOT_YET_RECRUITINGHershey, Pennsylvania, 17033, United States
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ADARx Clinical Site
NOT_YET_RECRUITINGCapital Federal, Buenos Aires, C1425BEN, Argentina
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ADARx Clinical Site
NOT_YET_RECRUITINGBuenos Aires, Buenos Aires F.D., C1035AAT, Argentina
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ADARx Clinical Site
NOT_YET_RECRUITINGAdelaide, South Australia, 5000, Australia
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ADARx Clinical Site
RECRUITINGVienna, 1090, Austria
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ADARx Clinical Site
NOT_YET_RECRUITINGEdegem, Antwerpen, 2650, Belgium
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ADARx Clinical Site
RECRUITINGSofia, 1000, Bulgaria
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ADARx Clinical Site
NOT_YET_RECRUITINGEdmonton, Alberta, T6G 2R3, Canada
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ADARx Clinical Site
RECRUITINGOttawa, Ontario, K1H 1E4, Canada
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ADARx Clinical Site
NOT_YET_RECRUITINGMontreal, Quebec, H2W 1R7, Canada
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ADARx Clinical Site
NOT_YET_RECRUITINGBeijing, 100730, China
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ADARx Clinical Site
NOT_YET_RECRUITINGHarbin, 150001, China
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ADARx Clinical Site
NOT_YET_RECRUITINGZhengzhou, 450003, China
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ADARx Clinical Site
RECRUITINGSplit, 21000, Croatia
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ADARx Clinical Site
RECRUITINGZagreb, 10000, Croatia
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ADARx Clinical Site
RECRUITINGHradec Králové, 500 05, Czechia
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ADARx Clinical Site
RECRUITINGPrague, 15000, Czechia
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ADARx Clinical Site
NOT_YET_RECRUITINGNice, Alpes-Maritimes, 06300, France
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ADARx Clinical Site
NOT_YET_RECRUITINGTours, Indre-et-Loire, 37000, France
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ADARx Clinical Site
NOT_YET_RECRUITINGMontpellier, 34295, France
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ADARx Clinical Site
NOT_YET_RECRUITINGParis, 75012, France
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ADARx Clinical Site
NOT_YET_RECRUITINGTübingen, Baden-Wurttemberg, 72076, Germany
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ADARx Clinical Site
NOT_YET_RECRUITINGHong Kong, 111, Hong Kong
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ADARx Clinical Site
RECRUITINGBudapest, 1088, Hungary
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ADARx Clinical Site
NOT_YET_RECRUITINGRamat Gan, Tel Aviv, 5262100, Israel
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ADARx Clinical Site
NOT_YET_RECRUITINGAshkelon, 7830604, Israel
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ADARx Clinical Site
NOT_YET_RECRUITINGTel Aviv, 64239, Israel
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ADARx Clinical Site
RECRUITINGLodz, 92-213, Poland
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ADARx Clinical Site
RECRUITINGWroclaw, 50-556, Poland
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ADARx Clinical Site
RECRUITINGBarcelona, 08907, Spain
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ADARx Clinical Site
RECRUITINGMadrid, 28007, Spain
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ADARx Clinical Site
RECRUITINGTaichung, 40705, Taiwan
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ADARx Clinical Site
RECRUITINGCambridge, CB2 0QQ, United Kingdom
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ADARx Clinical Site
RECRUITINGCardiff, CF14 4YS, United Kingdom
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ADARx Clinical Site
RECRUITINGLondon, E1 1BB, United Kingdom
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ADARx Clinical Site
RECRUITINGSouthampton, SO16 6YD, United Kingdom
Conditions
Explore the condition pages connected to this study.