New Immune-Targeting drug shows promise against tough stomach cancers

NCT ID NCT03504397

Summary

This study tested whether adding the drug zolbetuximab to standard chemotherapy works better than chemotherapy alone for adults with advanced stomach or gastroesophageal (GEJ) cancer that has spread and cannot be removed by surgery. Zolbetuximab is designed to attach to a specific protein (CLDN18.2) found on many of these cancer cells, which may help the body's immune system attack the tumor. The main goal was to see if the combination could delay cancer growth and help people live longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • CBCC Global Research, Inc. at Comprehensive Blood and Cancer

    Bakersfield, California, 93309, United States

  • Cancer Treatment Centers of America, Atlanta

    Newnan, Georgia, 30265, United States

  • Cancer Treatment Centers of America, Philadelphia

    Philadelphia, Pennsylvania, 19124, United States

  • City of Hope Nat'l Medical Center

    Duarte, California, 91010, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Earle A. Chiles Research Institute

    Portland, Oregon, 97213, United States

  • Health Partners Institute

    Saint Louis Park, Minnesota, 55426, United States

  • Inova Dwight and Martha Schar Cancer Institute

    Fairfax, Virginia, 22031, United States

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Lancaster General Hospital

    Lancaster, Pennsylvania, 17604, United States

  • Loma Linda University

    Loma Linda, California, 92354, United States

  • Maryland Oncology Hematology

    Brandywine, Maryland, 20613, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114-2696, United States

  • Memorial Cancer Institute - West

    Hollywood, Florida, 33021, United States

  • Memorial Hospital West

    Pembroke Pines, Florida, 33028, United States

  • Memorial Sloan Kettering Cancer Center

    Middletown, Connecticut, 07748-3052, United States

  • Memorial Sloan Kettering Cancer Center

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Cancer Center

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Cancer Center

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Center

    Uniondale, New York, 11553, United States

  • Mount Sinai School of Medicine

    New York, New York, 10029-6574, United States

  • MultiCare Regional Cancer Center - Gig Harbor

    Auburn, Washington, 98801, United States

  • Northwestern University Medical Center

    Chicago, Illinois, 60611, United States

  • Norton Cancer Institute

    Louisville, Kentucky, 40217, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Orlando Health Inc

    Orlando, Florida, 32806, United States

  • Pacific Shores Medical Group

    Huntington Beach, California, 92648, United States

  • Precision Cancer Research -Dayton Physicians Network

    Middletown, Ohio, 45042, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Rhode Island Hospital-Lifespan Cancer Institute

    Providence, Rhode Island, 02903, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Sanford Cancer Center

    Sioux Falls, South Dakota, 57104, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109, United States

  • Site AU61002

    Douglas, Queensland, 4814, Australia

  • Site AU61006

    East Bentleigh, Victoria, 3165, Australia

  • Site AU61007

    Kogarah, 2217, Australia

  • Site AU61008

    Adelaide, South Australia, 5011, Australia

  • Site AU61011

    Tugun, Queensland, 4224, Australia

  • Site BE32001

    Brussels, Bruxelles-Capitale, Région de, 1200, Belgium

  • Site BE32002

    Brussels, Liege, 1050, Belgium

  • Site BE32004

    Brussels, 1000, Belgium

  • Site BE32005

    Bruges, 8310, Belgium

  • Site BE32006

    Leuven, Vlaams Brabant, 3000, Belgium

  • Site BE32007

    Edegem, Antwerpen, 2650, Belgium

  • Site BE32008

    Mons, Hainaut, 7000, Belgium

  • Site BE32010

    Haine-Saint-Paul, 7100, Belgium

  • Site BE32011

    Charleroi, 6000, Belgium

  • Site BE32012

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Site BR55002

    Itajaí, Santa Catarina, 88301-220, Brazil

  • Site BR55003

    Santo André, São Paulo, 09060-650, Brazil

  • Site BR55004

    São Paulo, 08270-070, Brazil

  • Site BR55005

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Site BR55006

    Lajeado, Rio Grande do Sul, 95900000, Brazil

  • Site BR55007

    Barretos, São Paulo, 14784-400, Brazil

  • Site BR55009

    São Paulo, 01509-900, Brazil

  • Site BR55010

    Brasília, Federal District, 70200-730, Brazil

  • Site BR55015

    Rio de Janeiro, 22793-080, Brazil

  • Site BR55016

    Passo Fundo, 99010-260, Brazil

  • Site BR55017

    Belo Horizonte, 30130-090, Brazil

  • Site BR55018

    Santa Catarina, 88501-003, Brazil

  • Site CA15002

    Montreal, Quebec, H3T 1M5, Canada

  • Site CA15005

    Edmonton, Alberta, T6G 1Z2, Canada

  • Site CA15008

    Montreal, Quebec, H4A 3J1, Canada

  • Site CA15009

    Saint John, New Brunswick, E2L 4L4, Canada

  • Site CA15011

    Toronto, Ontario, M5G 1X5, Canada

  • Site CL56003

    Providencia, Santiago Metropolitan, 7500921, Chile

  • Site CL56005

    Santiago, 8330032, Chile

  • Site CL56007

    Valdivia, 5090000, Chile

  • Site CL56008

    Providencia, 7520378, Chile

  • Site CN86001

    Xiamen, China

  • Site CN86002

    Beijing, 100071, China

  • Site CN86003

    Haerbin, Heilongjiang, 150081, China

  • Site CN86004

    Hangzhou, Zhejiang, 310003, China

  • Site CN86005

    Hefei, 230022, China

  • Site CN86006

    Nanjing, Jiangsu, 210008, China

  • Site CN86008

    Zhengzhou, 450000, China

  • Site CN86009

    Beijing, 100030, China

  • Site CO57001

    Cali, Colombia

  • Site CO57002

    Medellín, 0574, Colombia

  • Site CO57005

    Cali, Valle del Cauca Department, Colombia

  • Site CO57006

    Medellín, Antioquia, 574, Colombia

  • Site CO57007

    Montería, Departamento de Córdoba, 230002, Colombia

  • Site CO57009

    Bogotá, DC, 110231, Colombia

  • Site DE49002

    Mainz, Rhineland-Palatinate, 55101, Germany

  • Site DE49004

    Leipzig, Saxony, 04103, Germany

  • Site DE49007

    München, Bavaria, 81925, Germany

  • Site DE49008

    Munich, Bavaria, 81377, Germany

  • Site DE49010

    Dresden, Saxony, 01307, Germany

  • Site DE49011

    Berlin, 13353, Germany

  • Site DE49012

    Berlin, 13125, Germany

  • Site DE49015

    Magdeburg, Saxony-Anhalt, 39104, Germany

  • Site DE49018

    Dresden, 1067, Germany

  • Site DE49019

    Heilbronn, 74078, Germany

  • Site DE49021

    Halle, Saxony-Anhalt, 06108, Germany

  • Site ES34003

    Murcia, 30120, Spain

  • Site ES34004

    Madrid, 28034, Spain

  • Site ES34005

    Barcelona, 08003, Spain

  • Site ES34006

    Zaragoza, 50009, Spain

  • Site ES34008

    Madrid, 28007, Spain

  • Site ES34010

    Ávila, Castille and León, 05004, Spain

  • Site ES34011

    Alcorcón, Madrid, 28925, Spain

  • Site ES34013

    Badalona, Barcelona, 08028, Spain

  • Site ES34015

    Barcelona, 08035, Spain

  • Site ES34016

    Barcelona, 08025, Spain

  • Site ES34017

    Madrid, 28033, Spain

  • Site ES34018

    Seville, 41009, Spain

  • Site ES34019

    Burgos, 09006, Spain

  • Site FR33001

    Rennes, Brittany Region, 35042, France

  • Site FR33002

    Paris, Paris, 75970, France

  • Site FR33003

    Lyon, Rhone, 69008, France

  • Site FR33005

    Nice, Provence-Alpes-Côte d'Azur Region, 06200, France

  • Site FR33006

    Poitiers, Vienne, 86021, France

  • Site FR33007

    Nice, 06189, France

  • Site FR33008

    Besançon, Franche-Comte, 25033, France

  • Site FR33009

    Dijon, Bourgogne-Franche-Comté, 21079, France

  • Site FR33010

    Brest, Brittany Region, 29609, France

  • Site FR33011

    Montpellier, Languedoc-Roussillon, 34298, France

  • Site FR33101

    Saint-Herblain, Pays de la Loire Region, 44805, France

  • Site FR33103

    Créteil, 94000, France

  • Site FR33104

    Saint-Priest-en-Jarez, 42270, France

  • Site GB44001

    Manchester, M20 4BX, United Kingdom

  • Site GB44002

    London, NW1 2PG, United Kingdom

  • Site GB44003

    Aberdeen, Aberdeenshire, AB25 2ZN, United Kingdom

  • Site GB44004

    London, W1G 6AD, United Kingdom

  • Site GB44008

    Leeds, LS7 9TF, United Kingdom

  • Site GB44009

    Coventry, CV2 2DX, United Kingdom

  • Site GB44101

    London, London, City of, SW3 6JJ, United Kingdom

  • Site GB44102

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Site GB44103

    Cambridge, CB2 0QQ, United Kingdom

  • Site GB44104

    Dundee, DD2 4BF, United Kingdom

  • Site IL97201

    Haifa, 3109601, Israel

  • Site IL97202

    Jerusalem, 91031, Israel

  • Site IL97203

    Tel Aviv, 64239, Israel

  • Site IL97206

    Kfar Saba, Central District, 44281, Israel

  • Site IL97209

    Holon, 58100, Israel

  • Site IL97210

    HaDarom, 7030000, Israel

  • Site IT39003

    Piacenza, 29100, Italy

  • Site IT39004

    Bergamo, 24127, Italy

  • Site IT39006

    Milan, 20132, Italy

  • Site IT39008

    Milan, 20141, Italy

  • Site IT39009

    Cremona, 26100, Italy

  • Site IT39011

    Meldola, Forli, 47014, Italy

  • Site IT39012

    Parma, 43126, Italy

  • Site IT39013

    Ancona, 60126, Italy

  • Site IT39015

    Roma, 00128, Italy

  • Site IT39016

    Padua, 35128, Italy

  • Site IT39018

    Perugia, 05100, Italy

  • Site IT39019

    Pisa, 56126, Italy

  • Site IT39020

    Monza, Lombardy, 20052, Italy

  • Site IT39021

    Modena, 41124, Italy

  • Site IT39022

    Reggio Emilia, 42123, Italy

  • Site IT39023

    Vicenza, VI, 36100, Italy

  • Site IT39024

    Turin to, 5-10126, Italy

  • Site IT39026

    Terni, 5100, Italy

  • Site JP81001

    Suita, Osaka, Japan

  • Site JP81002

    Matsuyama, Ehime, Japan

  • Site JP81003

    Kashiwa, Chiba, Japan

  • Site JP81004

    Osaka, Japan

  • Site JP81005

    Fukuoka, Japan

  • Site JP81006

    Chuo-ku, Tokyo, Japan

  • Site JP81007

    Sapporo, Hokkaido, Japan

  • Site JP81008

    Koto-ku, Tokyo, Japan

  • Site JP81009

    Nagoya, Aichi-ken, Japan

  • Site JP81010

    Kitaadachi-gun, Saitama, Japan

  • Site JP81011

    Osaka, Japan

  • Site JP81012

    Sunto-gun, Shizuoka, Japan

  • Site JP81013

    Bunkyo-ku, Tokyo, Japan

  • Site JP81014

    Kobe, Hyōgo, Japan

  • Site JP81015

    Hidaka, Saitama, Japan

  • Site KR82002

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Site KR82003

    Seoul, 03080, South Korea

  • Site KR82004

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Site KR82005

    Seoul, 05505, South Korea

  • Site KR82006

    Seoul, 6591, South Korea

  • Site KR82007

    Seoul, 152-703, South Korea

  • Site KR82008

    Incheon, 21556, South Korea

  • Site KR82009

    Suwon, Gyeonggido [Kyonggi-do], 16247, South Korea

  • Site MX52001

    Aguascalientes, 20230, Mexico

  • Site MX52002

    Mexico City, Mexico City, 06760, Mexico

  • Site MX52003

    Distrito Federal, 06720, Mexico

  • Site MX52004

    Oaxaca City, Mexico

  • Site MX52007

    Mexico City, Mexico City, 3100, Mexico

  • Site MX52008

    San Luis de Potosi, 78250, Mexico

  • Site MX52009

    Jalisco, 45030, Mexico

  • Site MX52010

    Veracruz, Ver, Veracruz, 91900, Mexico

  • Site PE51001

    Lima, L27, Peru

  • Site PE51003

    Arequipa, 4001, Peru

  • Site PE51004

    San Isidro, Lima region, L27, Peru

  • Site PE51005

    Lima, 15036, Peru

  • Site PE51006

    Lima, 15072, Peru

  • Site PL48002

    Brzozów, Podkarpackie Voivodeship, 36-20, Poland

  • Site PL48004

    Lublin, Lubusz Voivodeship, 20-090, Poland

  • Site PL48005

    Wieliszew, Masovian Voivodeship, 05-135, Poland

  • Site PL48007

    Ostrołęka, Masovian Voivodeship, 07-410, Poland

  • Site PL48009

    Warsaw, 02-781, Poland

  • Site TW88601

    Taipei, 112, Taiwan

  • Site TW88603

    Taichung, 404, Taiwan

  • Site TW88604

    Kaohsiung City, 833, Taiwan

  • Site TW88605

    Kwei-Shan, Taoyuan, 333, Taiwan

  • Site TW88606

    Taipei, 10002, Taiwan

  • Site TW88607

    Tainan, 704, Taiwan

  • Site TW88608

    Kaohsiung City, 80756, Taiwan

  • St. Jude Hospital Yorba Linda

    Fullerton, California, 92835, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794-9452, United States

  • The Angeles Clinic and Research Institute

    Los Angeles, California, 90025, United States

  • The Ohio State University Medical Center

    Columbus, Ohio, 43210, United States

  • The University of Arizona Medical Center

    Tucson, Arizona, 85724, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • University of Arizona

    Phoenix, Arizona, 85004, United States

  • University of California - San Francisco

    San Francisco, California, 94143, United States

  • University of California Davis

    Sacramento, California, 95817, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Maryland Medical Center(UMMC)Transplant Center

    Baltimore, Maryland, 21201, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Oklahoma Health Science Center

    Oklahoma City, Oklahoma, 73104, United States

Conditions

Explore the condition pages connected to this study.