One-Shot gene therapy could change wet AMD treatment

NCT ID NCT07317934

First seen Jan 08, 2026 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tests a new gene therapy called LX102 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The treatment is given as a single injection under the retina and is compared to standard eye injections. The goal is to see if LX102 can improve or maintain eyesight better than current treatments. About 332 adults aged 50 to 80 who have already responded to standard therapy will take part.

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Contacts and locations

Locations

  • Aier Eye Hospital Group Co., LTD. Changsha Aier Eye Hospital

    NOT_YET_RECRUITING

    Changsha, Hunan, 410015, China

  • Beijing Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100730, China

  • Central Theater Command General Hospital of PLA

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430060, China

  • Eye & ENT Hospital of Fudan University

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200031, China

  • Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong

    NOT_YET_RECRUITING

    Shantou, Guangdong, 515041, China

  • Peking Union Medical College Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100730, China

  • Qilu Hospital of Shandong University

    NOT_YET_RECRUITING

    Jinan, Shandong, 250012, China

  • Qingdao Eye Hospital Affiliated to Shandong First Medical University

    NOT_YET_RECRUITING

    Qingdao, Shandong, 266071, China

  • Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 201801, China

  • Shandong Eye Hospital

    NOT_YET_RECRUITING

    Jinan, Shandong, 250021, China

  • Shanghai General Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200080, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Shanxi Bethune Hospital

    NOT_YET_RECRUITING

    Taiyuan, Shanxi, 030032, China

  • Shanxi Eye Hospital

    NOT_YET_RECRUITING

    Taiyuan, Shanxi, 030002, China

  • Sichuan Provincial People's Hospital

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 646100, China

  • The Affiliated Eye Hospital of Nanjing Medical University

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210029, China

  • The Eye Hospital of Wenzhou Medical University

    NOT_YET_RECRUITING

    Wenzhou, Zhejiang, 325027, China

  • The First Affiliated Hospital of Air Force Medical University

    NOT_YET_RECRUITING

    Xi’an, Shanxi, 710032, China

  • The First Affiliated Hospital of Jinan University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, 510632, China

  • The First Affiliated Hospital of University of Science and Technology of China

    NOT_YET_RECRUITING

    Hefei, Anhui, 230601, China

  • The Second Affiliated Hospital of Chongqing Medical University

    NOT_YET_RECRUITING

    Chongqing, Chongqing Municipality, 400010, China

  • The Second Affiliated Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, Heilongjiang, 150001, China

  • The Second Hospital of Jilin University

    NOT_YET_RECRUITING

    Changchun, Jilin, 130022, China

  • The Second Xiangya Hospital, Central South University

    NOT_YET_RECRUITING

    Changsha, Hunan, 410011, China

  • Tianjin Eye Hospital

    NOT_YET_RECRUITING

    Tianjin, Tianjin Municipality, 300020, China

  • Tianjin Medical University Eye Hospital

    RECRUITING

    Tianjin, Tianjin Municipality, 300384, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West China Hospital, Sichuan University

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610041, China

  • Xi 'an People's Hospital (Xi 'an No.4 Hospital)

    NOT_YET_RECRUITING

    Xi’an, Shanxi, 710004, China

  • Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200092, China

  • Xuzhou First People's Hospital

    NOT_YET_RECRUITING

    Xuzhou, Jiangsu, 221002, China

  • Zhejiang Provincial People's Hospital

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310014, China

  • Zhongshan Ophthalmic Center, Sun Yat-sen University

    NOT_YET_RECRUITING

    Zhongshan, Guangdong, 510623, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.