Experimental eye injection aims to halt rare genetic vision loss
NCT ID NCT03364153
Summary
This completed Phase 2 trial tested whether regular injections of an experimental drug called Zimura into the eye could safely slow the progression of vision loss in people with a rare genetic eye disease called Stargardt's. The study involved 121 participants who received either the drug or a sham (fake) injection over 18 months to compare results. Researchers measured changes in the retina and vision to see if the treatment helped control the disease.
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Contacts and locations
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Locations
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AOU Policlinico Sant'Orsola Malpighi, U.O. Oftalmologia,
Bologna, 40138, Italy
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Augenklinik der LMU München
München, 80336, Germany
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Austin Retina Associates
Austin, Texas, 78705, United States
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Azienda Ospedaliera Universitaria Careggi
Florence, 50121, Italy
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Budapest Retina Institute
Budapest, 1133, Hungary
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Casey Eye Institute/Oregon Health & Science University
Portland, Oregon, 97239, United States
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Centre ophtalmologique des Quinzes Vingts
Paris, 75012, France
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Creteil University Eye Clinic University Paris EST
Créteil, 94010, France
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Fondazione Policlinico Tor Vergata, UOSD Patologie Retiniche
Rome, 00133, Italy
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Ganglion Medical Center
Pécs, 7621, Hungary
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Hadassah University Hospital
Jerusalem, 9112001, Israel
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Hopital de la Croix-Rousse
Lyon, Auvergne-Rhône-Alpes, 69004, France
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Institut de la Macula
Barcelona, 08022, Spain
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Jules Stein Eye Institute/ David Geffen School of Medicine
Los Angeles, California, 90095, United States
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Kaplan Medical Center
Rehovot, 7610001, Israel
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Moorfields Eye Hospital
London, EC1V 2PD, United Kingdom
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Ophthalmic Consultants of Boston
Boston, Massachusetts, 02114, United States
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Ospedale San Raffaele
Milan, 20132, Italy
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Palmetto Retina Center
West Columbia, South Carolina, 29169, United States
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Princess Alexandra Eye Pavillion
Edinburgh, EH3 9HA, United Kingdom
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Rabin Medical Center, Beilinson campus
Petah Tikva, 4941492, Israel
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Rambam Health Care Campus
Haifa, 3109601, Israel
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Retina Center of NJ, LLC.
Bloomfield, New Jersey, 07003, United States
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Retina Foundation of the Southwest
Dallas, Texas, 75231, United States
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Retina Specialty Institute
Pensacola, Florida, 32503, United States
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Retinal Research Institute
Phoenix, Arizona, 85053, United States
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Semmelweis Egyetem
Budapest, H-1083, Hungary
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Strategic Clinical Research Group
Willow Park, Texas, 76087, United States
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Szegedi Tudomanyegyetem, Szent-Gyorgyi Albert Klinikai Kozpont, Szemeszeti Klinika
Szeged, 6720, Hungary
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Tel-Aviv Sourasky Medical Center, Ichilov Hospital
Tel Aviv, 6423906, Israel
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The Retina Center
Minneapolis, Minnesota, 55404, United States
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UPMC Eye Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Bonn
Bonn, 53127, Germany
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University of Campania Luigi Vanvitelli Eye Clinic
Naples, 80131, Italy
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University of Debrecen DE KK Szemészeti Klinika
Debrecen, 4032, Hungary
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University of Michigan/Kellogg Eye Center
Ann Arbor, Michigan, 48105, United States
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University of Tuebingen
Tübingen, 72076, Germany
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University of Utah John A. Moran Eye Center
Salt Lake City, Utah, 84132, United States
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VitreoRetinal Associates
Gainesville, Florida, 32607, United States
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Wills Eye Hospital/Mid Atlantic Retina
Philadelphia, Pennsylvania, 19107, United States
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Wilmer Eye Institute, Johns Hopkins
Baltimore, Maryland, 21287, United States
Conditions
Explore the condition pages connected to this study.