Can heat and antifungals team up to beat a stubborn skin fungus?
NCT ID NCT06300138
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This trial tests whether combining an antifungal drug (itraconazole) with infrared heat therapy clears skin lesions from sporotrichosis better than either treatment alone. Sporotrichosis is a chronic fungal infection that can persist for months and become serious. Researchers will compare three groups: drug only, heat only, and both together, measuring how completely lesions clear after three months. The study also tracks side effects and whether lesions return.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Itraconazole (an antifungal drug) and infrared thermotherapy (a heat device)
- What this could lead to
- If the combination works, it could offer a faster, more effective way to clear sporotrichosis skin lesions and reduce the need for long antifungal courses.
- What could go wrong
- This is an early-stage trial with 150 participants, so results may not apply to everyone. Heat therapy requires multiple sessions and may cause discomfort or burns, and the drug can have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The results of pathology and fungal culture were all patients with sporotrichosis. * Informed consent to the purpose and content of the study, and follow-up as required * The physical condition and self-condition can cooperate with the treatment. Exclusion Criteria: * Subjects who are unable to maintain a relatively stable posture during treatment. * Those who are sensitive or allergic to this experimental drug. * Systemic antifungal or KI therapy within 12 months * Local antifungal therapy within 1 month. * Previous history of immunodeficiency virus (HIV) infection, or positive HIV antibody in screening period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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First Hospital of China Medical University
RECRUITINGShenyang, China