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Single infusion shows promise for rapidly clearing painful skin flares

NCT ID NCT03782792

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

Summary

This study tested whether a single intravenous dose of an experimental drug called spesolimab could quickly treat severe, sudden flares of generalized pustular psoriasis (GPP). It compared spesolimab to a placebo in 53 adult patients experiencing a moderate-to-severe flare. The main goal was to see if the drug could clear visible pustules within one week and improve other skin symptoms and pain over four weeks.

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Contacts and locations

Locations

  • 2nd Affiliated Hosp Zhejiang University College of Medical

    Hangzhou, 310009, China

  • Asahikawa Medical University Hospital

    Hokkaido, Asahikawa, 078-8510, Japan

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Farhat Hached Hospital

    Sousse, 4000, Tunisia

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180, Japan

  • HOP Robert Debré

    Reims, 51092, France

  • HOP Saint-André

    Bordeaux, 33000, France

  • HOP Saint-Louis

    Paris, 75010, France

  • Hedi Chaker Hospital, Department of Dermatology

    Tunisia, 1053, Tunisia

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586, Malaysia

  • Hospital Pakar Sultanah Fatimah

    Muar town, 84000, Malaysia

  • Hospital Pulau Pinang

    Pulau Pinang, 10990, Malaysia

  • Hospital Raja Permaisuri Bainun

    Negeri Perak/Ipoh, 30450, Malaysia

  • Hospital Selayang

    Kuala Selangor, 68100, Malaysia

  • Hospital Sultan Ismail

    Johor Bahru, 81100, Malaysia

  • Hospital Sultanah Aminah

    Johor Bahru, 80100, Malaysia

  • Huashan Hospital, Fudan University

    Shanghai, 200040, China

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Klinikum der Universität München - Campus Innenstadt

    München, 80337, Germany

  • La Rabta Hospital

    Tunis, 1007, Tunisia

  • Nagoya City University Hospital

    Aichi, Nagoya, 467-8602, Japan

  • National Taiwan University Hospital

    Taipei, 10016, Taiwan

  • National University Hospital

    Singapore, 119074, Singapore

  • Ramathibodi Hospital

    Ratchatewi, Bangkok, 10400, Thailand

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shanghai Skin Disease Hospital

    Shanghai, 200000, China

  • The First Hospital of Dalian Medical University

    Dalian, 116011, China

  • Tianjin Medical University General Hospital

    Tianjin, 30052, China

  • Tohoku University Hospital

    Miyagi, Sendai, 980-8574, Japan

  • Tokyo Medical University Hachioji Medical Center

    Tokyo, Hachioji, 193-0998, Japan

  • Tokyo Medical University Hospital

    Tokyo, Shinjuku-ku, 160-0023, Japan

  • University Hospital of Lausanne

    Lausanne, 1011, Switzerland

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of Miami

    Miami, Florida, 33125, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • Universitätsklinikum Bonn AöR

    Bonn, 53127, Germany

  • Universitätsklinikum Essen AöR

    Essen, 45147, Germany

Conditions

Explore the condition pages connected to this study.

GENERALIZED PUSTULAR PSORIASIS