Tiny study aims to unlock secrets of stuttering and aphasia

NCT ID NCT05437159

Completed Knowledge-focused Sponsor: Boston University Charles River Campus Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This study looks at how the brain plans and produces speech in people who stutter, those with primary progressive aphasia, and healthy speakers. Participants will practice saying made-up words with tricky sound combinations while researchers measure brain activity with MRI and track changes in speech accuracy and speed. The goal is to better understand the underlying brain mechanisms, which could eventually lead to new treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Learning of non-native phoneme combinations (behavioral training)
What this could lead to: If successful, this could improve understanding of speech disorders and pave the way for new therapies or technologies for stuttering and aphasia.
What could go wrong: This is a very small, early-stage observational study (only 2 participants) focused on basic brain mechanisms, not a treatment trial. Results may not lead directly to therapies.

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Conditions

The condition(s) this trial relates to.

GRN-related frontotemporal lobar degeneration with Tdp43 inclusions primary progressive aphasia speech disorder stutter disorder Stuttering

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APHASIA, PRIMARY PROGRESSIVE STUTTERING, DEVELOPMENTAL

Contacts and locations

Locations

Boston University

Boston, Massachusetts, 02215, United States
Massachusetts General Hospital

Boston, Massachusetts, 02129, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States

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