Tiny study aims to unlock secrets of stuttering and aphasia

NCT ID NCT05437159

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how the brain plans and produces speech in people who stutter, those with primary progressive aphasia, and healthy speakers. Participants will practice saying made-up words with tricky sound combinations while researchers measure brain activity with MRI and track changes in speech accuracy and speed. The goal is to better understand the underlying brain mechanisms, which could eventually lead to new treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Learning of non-native phoneme combinations (behavioral training)

What this could lead to

If successful, this could improve understanding of speech disorders and pave the way for new therapies or technologies for stuttering and aphasia.

What could go wrong

This is a very small, early-stage observational study (only 2 participants) focused on basic brain mechanisms, not a treatment trial. Results may not lead directly to therapies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

GRN-related frontotemporal lobar degeneration with Tdp43 inclusions primary progressive aphasia speech disorder stutter disorder Stuttering

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Boston University

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

    Contact

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02129, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact