New hope for sickle cell patients: drug may curb debilitating erections

NCT ID NCT03938454

First seen Jan 22, 2026 · Last updated May 14, 2026 · Updated 18 times

Summary

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who suffer from priapism—painful, unwanted erections lasting an hour or more. The goal was to see if the drug could reduce how often these episodes happen over 26 weeks. Participants reported their erections using an electronic system, and the results were compared to their baseline rates.

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Contacts and locations

Locations

  • Brody School of Medicine

    Greenville, North Carolina, 27834, United States

  • Childrens Hosp Boston Dept of Hematology

    Boston, Massachusetts, 02115, United States

  • Childrens National Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30303, United States

  • Foundation for Sickle Cell Disease Research

    Hollywood, Florida, 33021, United States

  • LSU Medical Center

    Shreveport, Louisiana, 71130, United States

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • Prisma Health Upstate

    Greenville, South Carolina, 29615, United States

  • University Of Alabama

    Birmingham, Alabama, 35294, United States

  • University of Connecticut Health Center

    Farmington, Connecticut, 06030, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213-2548, United States

  • University of Texas Medical School

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.