New drug shows promise in slowing kidney disease for FSGS patients

NCT ID NCT03493685

Completed Disease control Sponsor: Travere Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 24, 2026 · Last updated May 16, 2026 · Updated 5 times

Summary

This study tested a new medicine called sparsentan in 371 people with a rare kidney disease called FSGS. The goal was to see if it could slow down kidney damage better than a standard treatment. Participants took either sparsentan or a standard blood pressure pill, and researchers measured kidney function over two years.

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Contacts and locations

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Locations

Travere Investigational Site

Mesa, Arizona, 85210, United States
Travere Investigational Site

Phoenix, Arizona, 85027, United States
Travere Investigational Site

Los Angeles, California, 90048, United States
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Northridge, California, 91324, United States
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Palo Alto, California, 94304, United States
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San Diego, California, 92103, United States
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San Dimas, California, 91773, United States
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San Francisco, California, 94118, United States
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Torrance, California, 90502, United States
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Victorville, California, 92395, United States
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Denver, Colorado, 80205, United States
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Denver, Colorado, 80230, United States
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Middlebury, Connecticut, 06762, United States
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Wilmington, Delaware, 19803, United States
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Washington D.C., District of Columbia, 20010, United States
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Coral Springs, Florida, 33071, United States
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Fort Lauderdale, Florida, 33308, United States
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Gainesville, Florida, 32610, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33136, United States
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Miami, Florida, 33155, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32827, United States
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Port Charlotte, Florida, 33952, United States
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Temple Terrace, Florida, 33637, United States
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Winter Park, Florida, 32789, United States
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Lawrenceville, Georgia, 30046, United States
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Nampa, Idaho, 86387, United States
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Chicago, Illinois, 60611, United States
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Hinsdale, Illinois, 60521, United States
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Kansas City, Kansas, 66160, United States
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Wichita, Kansas, 67214, United States
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Louisville, Kentucky, 40202, United States
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Monroe, Louisiana, 71201, United States
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New Orleans, Louisiana, 70121, United States
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Shreveport, Louisiana, 71101, United States
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Boston, Massachusetts, 02111, United States
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Springfield, Massachusetts, 01107, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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Minneapolis, Minnesota, 55404, United States
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Minneapolis, Minnesota, 55455, United States
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Rochester, Minnesota, 55902, United States
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Kansas City, Missouri, 64108, United States
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Kansas City, Missouri, 64111, United States
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Las Vegas, Nevada, 89129, United States
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Reno, Nevada, 89511, United States
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Hackensack, New Jersey, 07601, United States
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Fresh Meadows, New York, 11365, United States
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New Hyde Park, New York, 11040, United States
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New York, New York, 10016, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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The Bronx, New York, 10467, United States
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Chapel Hill, North Carolina, 27514, United States
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Durham, North Carolina, 27710, United States
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Raleigh, North Carolina, 27609, United States
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Winston-Salem, North Carolina, 27103, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Oklahoma City, Oklahoma, 73104, United States
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Roseburg, Oregon, 97471, United States
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Bethlehem, Pennsylvania, 18017, United States
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Camp Hill, Pennsylvania, 17011, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15224, United States
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Upland, Pennsylvania, 19013, United States
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Columbia, South Carolina, 29203, United States
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Memphis, Tennessee, 38103, United States
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Corpus Christi, Texas, 78412, United States
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Dallas, Texas, 75231, United States
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Dallas, Texas, 75235, United States
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Dallas, Texas, 75246, United States
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El Paso, Texas, 79902, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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Lewisville, Texas, 75057, United States
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Sherman, Texas, 75090, United States
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Salt Lake City, Utah, 84112, United States
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Salt Lake City, Utah, 84115, United States
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St. George, Utah, 84790, United States
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Hampton, Virginia, 23666, United States
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Spokane, Washington, 99204, United States
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Morgantown, West Virginia, 26506, United States
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Marshfield, Wisconsin, 54449, United States
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Wauwatosa, Wisconsin, 53226, United States
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Buenos Aires, C1280AEB, Argentina
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Córdoba, X5000JHGQ, Argentina
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Córdoba, X5016LIG, Argentina
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Santa Fe, S3000, Argentina
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Concord, New South Wales, 2139, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Saint Leonards, New South Wales, 2065, Australia
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Wollongong, New South Wales, 2522, Australia
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Birtinya, Queensland, 4575, Australia
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Woolloongabba, Queensland, 4102, Australia
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Adelaide, South Australia, 5000, Australia
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Parkville, Victoria, 3050, Australia
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Nedlands, Western Australia, 6009, Australia
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Roeselare, 8800, Belgium
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Botucatu, 18618-686, Brazil
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Itaquera, 08270-120, Brazil
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Passo Fundo, 99010-080, Brazil
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Porto Alegre, 90035-903, Brazil
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Recife, 50670-901, Brazil
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Rio de Janeiro, 20551-030, Brazil
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São Paulo, 04038-002, Brazil
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São Paulo, 05403-000, Brazil
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Edmonton, Alberta, T6G 2B7, Canada
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London, Ontario, N6A 5A5, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Zagreb, 10000, Croatia
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Prague, Prague, 100 34, Czechia
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Prague, Prague, 120 00, Czechia
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Nový Jičín, 74101, Czechia
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Aarhus, Central Jutland, 8200, Denmark
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Kolding, Southern Denmark, 6000, Denmark
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Tallinn, 10617, Estonia
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Tartu, 50406, Estonia
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Bordeaux, 33076, France
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Clermont-Ferrand, 63003, France
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Créteil, 94000, France
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Grenoble, 38043, France
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Marseille, 13005, France
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Nice, 06001, France
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Paris, 75010, France
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Paris, 75015, France
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Paris, 75743, France
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Saint-Priest-en-Jarez, 42270, France
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Toulouse, 31059, France
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Valenciennes, 59322, France
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Düsseldorf, Westfalen, 40210, Germany
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Aachen, 52074, Germany
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Berlin, 10117, Germany
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Berlin, 12203, Germany
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Hanover, 30625, Germany
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Stuttgart, 70376, Germany
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Villingen-Schwenningen, 78052, Germany
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Hong Kong, Hong Kong
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Lai Chi Kok, Hong Kong
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Bari, 70124, Italy
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Florence, 50134, Italy
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Genova, 16132, Italy
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Germaneto, 88100, Italy
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Lecco, 23900, Italy
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Milan, 20122, Italy
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Monza, 20900, Italy
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Pavia, 27100, Italy
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Roma, 168, Italy
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Verona, 37126, Italy
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Auckland, 1051, New Zealand
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Hamilton, 3204, New Zealand
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Lodz, 93-347, Poland
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Olsztyn, 10-117, Poland
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Olsztyn, 10-561, Poland
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Piotrkow Trybunalski, 97-300, Poland
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Warsaw, 00-631, Poland
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Warsaw, 04-749, Poland
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Wroclaw, 50-556, Poland
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Amadora, 2720-276, Portugal
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Carnaxide, 2790-134, Portugal
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Lisbon, 1050-099, Portugal
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Lisbon, 1649-035, Portugal
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Loures, 2674-514, Portugal
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Porto, 4200-319, Portugal
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Setúbal, 2910-446, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Busan, 47392, South Korea
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Daejeon, 35015, South Korea
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Gyeonggi-do, 13620, South Korea
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Gyeonggi-do, 14068, South Korea
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Seoul, 3080, South Korea
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Seoul, 3722, South Korea
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Palma de Mallorca, Balearic Islands, 07120, Spain
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Lugo, Burela, 27880, Spain
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Sagunto, Valencia, 46520, Spain
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Badalona, 8916, Spain
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Barcelona, 08003, Spain
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Barcelona, 08025, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Ciudad Real, 13005, Spain
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Córdoba, 14004, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
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Valencia, 46014, Spain
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Valencia, 46017, Spain
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Zaragoza, 50009, Spain
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Solna, SE-171 64, Sweden
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Uppsala, 75237, Sweden
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Uppsala, SE-751 85, Sweden
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Hualien City, 970, Taiwan
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Kaohsiung City, 81362, Taiwan
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New Taipei City, 235, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10048, Taiwan
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Taipei, 104, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Carshalton, London, SM5 1AA, United Kingdom
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Whitechapel, London, E1 1BB, United Kingdom
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Fulwood, Preston, PR2 9HT, United Kingdom
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Brighton, BN2 5BE, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Cardiff, CF14 4XW, United Kingdom
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Leicester, LE5 4PW, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE5 9RS, United Kingdom
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Manchester, M13 9WL, United Kingdom
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Newcastle, NE7 7DN, United Kingdom
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Reading, RG1 5AN, United Kingdom
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Salford, M6 8HD, United Kingdom
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Swansea, SA6 6NL, United Kingdom
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York, YO31 8HE, United Kingdom

Conditions

Explore the condition pages connected to this study.

FOCAL SEGMENTAL GLOMERULOSCLEROSIS