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New hope for a stiff heart: major trial tests drug to ease debilitating symptoms

NCT ID NCT06481891

Recruiting now Symptom relief Sponsor: Lexicon Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether the drug sotagliflozin can improve symptoms and daily life for people living with symptomatic hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. About 500 participants will be randomly assigned to receive either the study drug or a placebo for 26 weeks. The main goal is to see if the drug helps people feel better, be more active, and improves their quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Lexicon Investigational Site (1012)

    RECRUITING

    Genk, 3600, Belgium

  • Lexicon Investigational Site (1111)

    RECRUITING

    Sofia, 1407, Bulgaria

  • Lexicon Investigational Site (1112)

    RECRUITING

    Rousse, 7013, Bulgaria

  • Lexicon Investigational Site (1210)

    RECRUITING

    Rijeka, 51000, Croatia

  • Lexicon Investigational Site (1212)

    RECRUITING

    Opatija, 51410, Croatia

  • Lexicon Investigational Site (1213)

    RECRUITING

    Zagreb, 10000, Croatia

  • Lexicon Investigational Site (1215)

    RECRUITING

    Krapinske Toplice, 49217, Croatia

  • Lexicon Investigational Site (1310)

    RECRUITING

    Prague, 128 08, Czechia

  • Lexicon Investigational Site (1311)

    RECRUITING

    Brno, 602 00, Czechia

  • Lexicon Investigational Site (1312)

    RECRUITING

    Ústí nad Labem, 400 11, Czechia

  • Lexicon Investigational Site (1510)

    RECRUITING

    Poitiers, 86021, France

  • Lexicon Investigational Site (1511)

    RECRUITING

    Marseille, 13005, France

  • Lexicon Investigational Site (1512)

    RECRUITING

    Rennes, 35033, France

  • Lexicon Investigational Site (1513)

    RECRUITING

    Paris, 75651, France

  • Lexicon Investigational Site (1514)

    RECRUITING

    Chambray-lès-Tours, 37170, France

  • Lexicon Investigational Site (1515)

    RECRUITING

    Toulouse, 31059, France

  • Lexicon Investigational Site (1610)

    RECRUITING

    Tbilisi, 0131, Georgia

  • Lexicon Investigational Site (1611)

    RECRUITING

    Tbilisi, 0112, Georgia

  • Lexicon Investigational Site (1612)

    RECRUITING

    Tbilisi, 0144, Georgia

  • Lexicon Investigational Site (1613)

    RECRUITING

    Tbilisi, 0186, Georgia

  • Lexicon Investigational Site (1710)

    RECRUITING

    Budapest, 1122, Hungary

  • Lexicon Investigational Site (1711)

    RECRUITING

    Pécs, 7624, Hungary

  • Lexicon Investigational Site (1712)

    RECRUITING

    Szeged, 6725, Hungary

  • Lexicon Investigational Site (1713)

    RECRUITING

    Zalaegerszeg, 8900, Hungary

  • Lexicon Investigational Site (1811)

    RECRUITING

    Brescia, 25123, Italy

  • Lexicon Investigational Site (1813)

    RECRUITING

    Naples, 80131, Italy

  • Lexicon Investigational Site (1814)

    RECRUITING

    Arezzo, 52100, Italy

  • Lexicon Investigational Site (2110)

    RECRUITING

    Wroclaw, 50-981, Poland

  • Lexicon Investigational Site (2113)

    RECRUITING

    Lodz, 92-213, Poland

  • Lexicon Investigational Site (2114)

    RECRUITING

    Lodz, 91-347, Poland

  • Lexicon Investigational Site (2115)

    RECRUITING

    Oświęcim, 32-600, Poland

  • Lexicon Investigational Site (2210)

    RECRUITING

    Braga, 4710-243, Portugal

  • Lexicon Investigational Site (2211)

    RECRUITING

    Lisbon, 1350-352, Portugal

  • Lexicon Investigational Site (2213)

    RECRUITING

    Faro, 8000-386, Portugal

  • Lexicon Investigational Site (2215)

    RECRUITING

    Lisbon, 1500-650, Portugal

  • Lexicon Investigational Site (2216)

    RECRUITING

    Lisbon, 1998-018, Portugal

  • Lexicon Investigational Site (2217)

    RECRUITING

    Porto, 4200-319, Portugal

  • Lexicon Investigational Site (2218)

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Lexicon Investigational Site (2310)

    RECRUITING

    Niš, 18108, Serbia

  • Lexicon Investigational Site (2311)

    RECRUITING

    Belgrade, 11040, Serbia

  • Lexicon Investigational Site (2312)

    RECRUITING

    Belgrade, 11000, Serbia

  • Lexicon Investigational Site (2313)

    RECRUITING

    Belgrade, 11040, Serbia

  • Lexicon Investigational Site (2314)

    RECRUITING

    Belgrade, 11000, Serbia

  • Lexicon Investigational Site (2510)

    RECRUITING

    Stockholm, 17164, Sweden

  • Lexicon Investigational Site (2710)

    RECRUITING

    Liverpool, L14 3PE, United Kingdom

  • Lexicon Investigational Site (2711)

    RECRUITING

    London, EC1M 6BQ, United Kingdom

  • Lexicon Investigational Site (2712)

    RECRUITING

    Glasgow, G51 4TF, United Kingdom

  • Lexicon Investigational Site (2713)

    RECRUITING

    Leicester, LE3 9QP, United Kingdom

  • Lexicon Investigational Site (2810)

    RECRUITING

    München, 80336, Germany

  • Lexicon Investigational Site (2811)

    RECRUITING

    Leipzig, 04289, Germany

  • Lexicon Investigational Site (2812)

    RECRUITING

    Hamburg, 22041, Germany

  • Lexicon Investigational Site (2813)

    RECRUITING

    Berlin, 13353, Germany

  • Lexicon Investigational Site (2910)

    RECRUITING

    Baloteşti, 077015, Romania

  • Lexicon Investigational Site (2911)

    RECRUITING

    Târgu Mureş, 540124, Romania

  • Lexicon Investigational Site (2912)

    RECRUITING

    Târgu Mureş, 540143, Romania

  • Lexicon Investigational Site (2913)

    RECRUITING

    Suceava, 720049, Romania

  • Lexicon Investigational Site (4010)

    RECRUITING

    Seattle, Washington, 98195, United States

  • Lexicon Investigational Site (4011)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Lexicon Investigational Site (4012)

    RECRUITING

    Los Angeles, California, 90048, United States

  • Lexicon Investigational Site (4013)

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Lexicon Investigational Site (4015)

    RECRUITING

    Portland, Oregon, 97239, United States

  • Lexicon Investigational Site (4016)

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Lexicon Investigational Site (4017)

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Lexicon Investigational Site (4018)

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Lexicon Investigational Site (4019)

    RECRUITING

    Germantown, Tennessee, 38138, United States

  • Lexicon Investigational Site (4021)

    RECRUITING

    Baltimore, Maryland, 21218, United States

  • Lexicon Investigational Site (4022)

    RECRUITING

    Marshfield, Wisconsin, 54449, United States

  • Lexicon Investigational Site (4024)

    RECRUITING

    Tulsa, Oklahoma, 74104, United States

  • Lexicon Investigational Site (4026)

    RECRUITING

    Morrisville, North Carolina, 27560, United States

  • Lexicon Investigational Site (4027)

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Lexicon Investigational Site (4028)

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Lexicon Investigational Site (4029)

    RECRUITING

    Morristown, New Jersey, 07960, United States

  • Lexicon Investigational Site (4031)

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • Lexicon Investigational Site (4032)

    RECRUITING

    Charlottesville, Virginia, 22908, United States

  • Lexicon Investigational Site (4033)

    RECRUITING

    Evanston, Illinois, 60208, United States

  • Lexicon Investigational Site (4034)

    RECRUITING

    Orlando, Florida, 32804, United States

  • Lexicon Investigational Site (4035)

    RECRUITING

    Pomona, California, 91767, United States

  • Lexicon Investigational Site (4036)

    RECRUITING

    Merrillville, Indiana, 46410, United States

  • Lexicon Investigational Site (4037)

    RECRUITING

    Scottsdale, Arizona, 85260, United States

  • Lexicon Investigational Site (4038)

    RECRUITING

    Grand Rapids, Michigan, 49525, United States

  • Lexicon Investigational Site (4039)

    RECRUITING

    Manhasset, New York, 11030, United States

  • Lexicon Investigational Site (4040)

    RECRUITING

    Milwaukee, Wisconsin, 53215, United States

  • Lexicon Investigational Site (4041)

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Lexicon Investigational Site (4042)

    RECRUITING

    Boston, Massachusetts, 02118, United States

  • Lexicon Investigational Site (4043)

    RECRUITING

    New York, New York, 10016, United States

  • Lexicon Investigational Site (4044)

    RECRUITING

    San Francisco, California, 94143, United States

  • Lexicon Investigational Site (4046)

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Lexicon Investigational Site (5010)

    RECRUITING

    Córdoba, 5002, Argentina

  • Lexicon Investigational Site (5011)

    RECRUITING

    Salta, 4400, Argentina

  • Lexicon Investigational Site (5012)

    RECRUITING

    Rosario, Santa Fe Province, 2000, Argentina

  • Lexicon Investigational Site (5013)

    RECRUITING

    Córdoba, X5000AAX, Argentina

  • Lexicon Investigational Site (5014)

    RECRUITING

    Santa Fe, 3000, Argentina

  • Lexicon Investigational Site (5015)

    RECRUITING

    Corrientes, W3400CDS, Argentina

  • Lexicon Investigational Site (5016)

    RECRUITING

    Santa Rosa, La Pampa Province, L6304BWE, Argentina

  • Lexicon Investigational Site (5110)

    RECRUITING

    Campinas, São Paulo, 13060-080, Brazil

  • Lexicon Investigational Site (5112)

    RECRUITING

    Recife, 52051-380, Brazil

  • Lexicon Investigational Site (5114)

    RECRUITING

    Salvador, Estado de Bahia, 40170-130, Brazil

  • Lexicon Investigational Site (5115)

    RECRUITING

    São Paulo, 04039-000, Brazil

  • Lexicon Investigational Site (7011)

    RECRUITING

    Jerusalem, 9112001, Israel

  • Lexicon Investigational Site (7012)

    RECRUITING

    Ramat Gan, 5265601, Israel

  • Lexicon Investigational Site (7013)

    RECRUITING

    Haifa, 3109601, Israel

  • Lexicon Investigational Site (7014)

    RECRUITING

    Haifa, 3339419, Israel

  • Lexicon Investigational Site (7015)

    RECRUITING

    Holon, 5822012, Israel

  • Lexicon Investigational Site (7016)

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Lexicon Investigational Site (7017)

    RECRUITING

    Be’er Ya‘aqov, 7033001, Israel

  • Lexicon Investigational Site (7019)

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Lexicon Investigational Stie (4014)

    RECRUITING

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.

NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY OBSTRUCTIVE CARDIOMYOPATHY, HYPERTROPHIC