New hope for drug-resistant stomach cancer: sorafenib shows promise in early trial

NCT ID NCT00265798

First seen May 02, 2026 · Last updated Jun 08, 2026 · Updated 6 times

Summary

This study tested the drug sorafenib in 38 people with advanced gastrointestinal stromal tumor (GIST) that had stopped responding to two standard treatments, imatinib and sunitinib. Sorafenib works by blocking enzymes that help tumor cells grow and by cutting off blood supply to the tumor. The main goal was to see if the drug could shrink tumors or slow disease progression.

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Contacts and locations

Locations

  • Central Illinois Hematology Oncology Center

    Springfield, Illinois, 62702, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

Conditions

Explore the condition pages connected to this study.