New drug combo shows promise for rare blood cancer
NCT ID NCT05952037
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 study tests a new drug called sonrotoclax, either alone or combined with zanubrutinib, in 114 people with Waldenström macroglobulinemia, a rare blood cancer. The goal is to see if the treatment can shrink tumors and control the disease. Participants include those whose cancer has returned or not responded to prior therapy, as well as some newly diagnosed patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sonrotoclax (a BCL2 inhibitor) and zanubrutinib (a BTK inhibitor)
- What this could lead to
- If successful, this combination could offer a new, effective treatment option for Waldenström macroglobulinemia, helping to control the disease and improve outcomes.
- What could go wrong
- This is a mid-stage trial with only 114 participants, so results may not apply to everyone. The drugs may cause side effects like low blood counts or infections, and the treatment may not work for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated Zhongshan Hospital of Fudan University
Shanghai, Shanghai Municipality, 200032, China
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Atrium Health Levine Cancer Institute (Lci)
Charlotte, North Carolina, 28204-2990, United States
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Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Universitario Santa Maria Del
Udine, 33100, Italy
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Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Brescia, 25123, Italy
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Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
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Centre Hospitalier Universitaire Damiens Hopital Sud
Amiens, 80054, France
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Chu Clermont Ferrand Therapie Cellulaire and Hematolo
Clermontferrand, 63100, France
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Chu Hopital Lyon Sud
PierreBenite, 69495, France
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Churchill Hospital Oxford University Hospital Nhs Trust
Headington, OX3 7LE, United Kingdom
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City of Hope National Medical Center
Duarte, California, 91010-3012, United States
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Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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Concord Repatriation General Hospital
Concord, New South Wales, NSW 2139, Australia
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Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215-5418, United States
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Flinders Medical Centre
Bedford PK, South Australia, SA 5042, Australia
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Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168, Italy
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General Hospital of Athens Alexandra
Athens, 115 28, Greece
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Genesiscare North Shore
St Leonards, New South Wales, NSW 2065, Australia
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Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, 510080, China
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Hattiesburg Hematology and Oncology Clinic
Hattiesburg, Mississippi, 39401-7233, United States
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Henan Cancer Hospital
Zhengzhou, Henan, 450000, China
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Hopital Robert Debre
Reims, 51100, France
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Hopital de La Pitie Salpetriere
Paris, 75013, France
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Hospital Clinic de Barcelona
Barcelona, 8036, Spain
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Hospital Universitari Mutua Terrassa
Terrassa, 8221, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Vall Dhebron
Barcelona, 08035, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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Hospital Universitario de Salamanca
Salamanca, 37007, Spain
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112-5550, United States
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Institut Catala Doncologia
Barcelona, 08908, Spain
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Institut Paoli Calmettes
Marseille, 13009, France
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Institute of Hematology and Hospital of Blood Disease
Tianjin, Tianjin Municipality, 300020, China
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Irccs Azienda Ospedaliero Universitaria Bologna
Bologna, 40138, Italy
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Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi
Pavia, 27100, Italy
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Istituto Europeo Di Oncologia
Milan, 20141, Italy
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Linear Clinical Research
Nedlands, Western Australia, WA 6009, Australia
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Lions Gate Hospital Chemotherapy Clinic
North Vancouver, British Columbia, V7L 2L7, Canada
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Mayo Clinic Rochester
Rochester, Minnesota, 55905-0001, United States
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Medstar Georgetown University Hospital
Washington D.C., District of Columbia, 20007-2113, United States
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Memorial Sloan Kettering Cancer Center Mskcc
New York, New York, 10065-6800, United States
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Mission Cancer and Blood
Waukee, Iowa, 50263, United States
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Monash Health
Clayton, Victoria, VIC 3168, Australia
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Nhs Highland
Inverness, IV2 3BW, United Kingdom
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Northwestern Medicine Cancer Center
Warrenville, Illinois, 60555-3269, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210-1280, United States
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Plymouth Hospitals Nhs Trust
Plymouth, PL6 8DH, United Kingdom
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Princess Alexandra Hospital
Woolloongabba, Queensland, QLD 4102, Australia
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Qeii Health Science Center
Halifax, Nova Scotia, B3H 2Y9, Canada
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Royal Marsden Nhs Foundation Royal Marsden Hospital
Sutton, SM2 5PT, United Kingdom
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Royal Perth Hospital
Perth, Western Australia, WA 6000, Australia
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Shengjing Hospital of China Medical Universityshenbei Branch
Shenyang, Liaoning, 110134, China
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St Jamess University Hospital
Leeds, LS9 7TF, United Kingdom
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St Vincents Hospital Melbourne
Fitzroy, Victoria, VIC 3065, Australia
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The Affiliated Hospital of Qingdao University Branch South
Qingdao, Shandong, 266000, China
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The Christie Nhs Foundation Trust Manchester
Manchester, M20 4BX, United Kingdom
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, 325000, China
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The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, 361003, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
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The First Hospital of Jiaxing
Jiaxing, Zhejiang, 314001, China
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The Third Peoples Hospital of Datong
Datong, Shanxi, 037008, China
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Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
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University College Hospital
London, NW1 2PG, United Kingdom
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University Hospitals Dorset
Bournemouth, BH7 7DW, United Kingdom
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University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201-1544, United States
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University of Miami
Miami, Florida, 33136-2107, United States
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University of Washington
Seattle, Washington, 98195, United States
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Ut Southwestern Medical Center
Dallas, Texas, 75390-7208, United States
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Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia, 23298, United States
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Yancheng First Peoples Hospital
Yancheng, Jiangsu, 224006, China
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