New hope for tough lymphoma: sonrotoclax trial underway
NCT ID NCT05471843
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a drug called sonrotoclax (BGB-11417) in 125 people with mantle cell lymphoma that has relapsed or not responded to prior treatments. The trial has two parts: first to find the safest dose, then to see how well it shrinks tumors. Participants take the drug by mouth, and researchers monitor side effects and cancer response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sonrotoclax (BGB-11417)
- What this could lead to
- If it works, this could offer a new treatment option for people with mantle cell lymphoma that has stopped responding to other therapies.
- What could go wrong
- This is an early-phase trial with only 125 participants, so results may not apply to everyone. Side effects like tumor lysis syndrome are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AZ DELTA
Roeselare, 8800, Belgium
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Accamargo Cancer Center
São Paulo, 01508-010, Brazil
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Affiliated Cancer Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830000, China
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Affiliated Hospital of Nantong University
Nantong, Jiangsu, 201203, China
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Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital
Hefei, Anhui, 230088, China
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Ankara University Medical Faculty
Ankara, 06620, Turkey (Türkiye)
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Aou Maggiore Della Carita
Novara, 28100, Italy
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Assuta Ashdod Medical Center
Ashdod, 7747629, Israel
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Auxilio Mutuo Cancer Center
San Juan, 00917, Puerto Rico
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Az Sint Jan Brugge
Bruges, 8000, Belgium
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Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Brescia, 25123, Italy
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Bagcilar Medipol Mega Hospital
Istanbul, 34214, Turkey (Türkiye)
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Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
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Beijing Friendship Hospital, Capital Medical University(Tongzhou)
Beijing, Beijing Municipality, 101100, China
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Cancer Hospital of Guizhou Medical University
Guiyang, Guizhou, 550000, China
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Centre Hospitalier Le Mans
Le Mans, 72037, France
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Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, 44093, France
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China Japan Friendship Hospital
Beijing, Beijing Municipality, 100029, China
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Chu Hopital Lyon Sud
PierreBenite, 69495, France
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Chu Tours Hopital Bretonneau Service Pneumologie
Tours, 37000, France
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Churchill Hospital Oxford University Hospital Nhs Trust
Headington, OX3 7LE, United Kingdom
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Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Dartmouth Cancer Center
Lebanon, New Hampshire, 03756, United States
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Des Moines Oncology Research Association
Des Moines, Iowa, 50309, United States
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Dr Abdurrahman Yurtaslan Oncology Teaching and Research Hospital
Ankara, 06620, Turkey (Türkiye)
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Ege University Medical Faculty
Izmir, 35100, Turkey (Türkiye)
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Erciyes University School of Medicine
Kayseri, 38039, Turkey (Türkiye)
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Fort Wayne Medical Oncology and Hematology
Fort Wayne, Indiana, 46804, United States
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Fujian Cancer Hospital
Fuzhou, Fujian, 350014, China
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Gazi University
Ankara, 6500, Turkey (Türkiye)
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General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004, China
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Guangdong Provincial Peoples Hospital Huifu Branch
Guangzhou, Guangdong, 510120, China
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hadassah En Karem Medical Center
Jerusalem, 9112001, Israel
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Hainan General Hospital
Haikou, Hainan, 570206, China
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Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
São Paulo, 05402-000, Brazil
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Henan Cancer Hospital
Zhengzhou, Henan, 450000, China
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Hopital Pitie Salpetriere Service Hematologie
Paris, 75013, France
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Hospital Aleman
Buenos Aires, C1118, Argentina
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Hospital Beneficencia Portuguesa de Sao Paulo
São Paulo, 01323-001, Brazil
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Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
Ribeirão Preto, 14051-140, Brazil
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Hospital Erasto Gaertner
Curitiba, 81520-060, Brazil
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Hospital Mae de Deus
Porto Alegre, 90110-270, Brazil
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Hospital Sao Rafael (Rede Dor)
Salvador, 41253-190, Brazil
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Vall Dhebron
Barcelona, 08035, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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Institute of Hematology and Hospital of Blood Disease
Tianjin, Tianjin Municipality, 300020, China
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Instituto Americas Ensino, Pesquisa E Inovacao
Rio de Janeiro, 22775-001, Brazil
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Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, 01401-002, Brazil
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Irccs Istituto Tumori Giovanni Paolo Ii
Bari, 70124, Italy
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Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst
Meldola, 47014, Italy
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Jiangmen Central Hospital
Jiangmen, Guangdong, 529030, China
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Jiangsu Province Hospital
Nanjing, Jiangsu, 210029, China
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Jiangxi Province Cancer Hospital
Nanchang, Jiangxi, 330029, China
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Kocaeli Universitesi Tip Fakultesi
Kocaeli, 41380, Turkey (Türkiye)
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Liaoning Cancer Hospital and Institute
Shenyang, Liaoning, 110042, China
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Luminis Health Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
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Maryland Oncology Hematology, Pa
Columbia, Maryland, 21044, United States
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Medstar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Narodowy Instytut Onkologii Im Marii Skodowskiej Curie Pastwowy Instytut Badawczy
Warsaw, 02-034, Poland
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Nebraska Cancer Specialists
Grand Island, Nebraska, 68803, United States
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Necker University Hospital
Paris, 75015, France
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Novant Health Hematology Charlotte
Charlotte, North Carolina, 28204, United States
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Oncoclinicas Rio de Janeiro Sa
Rio de Janeiro, 22250-905, Brazil
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Ondokuz Mayis University Medicine Faculty Hospital
Atakum Samsun, 55200, Turkey (Türkiye)
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Policlinico Sorsola Malpighi, Aou Di Bologna
Bologna, 40138, Italy
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Pratia McM Krakow
Krakow, 30-727, Poland
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Qeii Health Science Center
Halifax, Nova Scotia, B3H 2Y9, Canada
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Rabin Medical Center
Petah Tikva, 49100, Israel
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Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
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Shandong Cancer Hospital
Jinan, Shandong, 250117, China
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Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi, 030013, China
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Sheba Medical Center
Tel Aviv, 5262100, Israel
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Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05653-120, Brazil
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Sourasky Tel Aviv Medical Center
Tel Aviv, 64239, Israel
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Sun Yat Sen University Cancer Center
Guangzhou, Guangdong, 510060, China
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The Affiliated Hospital of Qingdao University Branch West Coast
Qingdao, Shandong, 266555, China
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The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, 221000, China
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The Christie Hospital
Greater Manchester, M20 4BX, United Kingdom
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The First Affiliated Hospital of Nanchang University Branch Donghu
Nanchang, Jiangxi, 330006, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
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The First Peoples Hospital of Kashgar
Kashgar, Xinjiang, 844099, China
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The Tumor Hospital Affiliated to Guangxi Medical University
Nanning, Guangxi, 530021, China
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The University of Texas Md Anderson Cancer Center
Houston, Texas, 77030-4009, United States
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, 300060, China
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Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
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Tulane Cancer Center
New Orleans, Louisiana, 70112, United States
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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Universitatsklinikum Dusseldorf
Düsseldorf, 40225, Germany
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Universitatsklinikum Essen (Aor)
Essen, D-45147, Germany
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Universitatsklinikum Koln, Innere Medizin I
Cologne, 50937, Germany
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Universitatsklinikum Schleswig Holstein, Campus Kiel
Kiel, 24105, Germany
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University College Hospital
London, NW1 2PG, United Kingdom
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University Hospitals Leuven
Leuven, 3000, Belgium
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University of Alabama At Birmingham Hospital
Birmingham, Alabama, 35294, United States
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University of Missouri Hospital, Ellis Fischel Cancer Center
Columbia, Missouri, 65212, United States
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Uniwersytecki Szpital Kliniczny Nr W Lublinie
Lublin, 20-090, Poland
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Uniwersyteckie Centrum Kliniczne
Gdansk, 80-952, Poland
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Vkv American Hospital
Istanbul, 34365, Turkey (Türkiye)
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West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
More trials for these conditions
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- New drug combo aims to outsmart Hard-to-Treat lymphoma