New drug combo shows promise against rare liver virus

NCT ID NCT05461170

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 30 times

Summary

This study tests two experimental drugs, VIR-2218 and VIR-3434, in about 95 adults with chronic hepatitis D, a serious liver infection. The goal is to see if the drugs can lower the virus to undetectable levels and improve liver function. Participants must have had hepatitis D for at least 6 months and be on stable hepatitis B treatment.

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Contacts and locations

Locations

  • Investigative Site

    Sofia, 1407, Bulgaria

  • Investigative Site

    Sofia, 1431, Bulgaria

  • Investigative Site

    Stara Zagora, 6003, Bulgaria

  • Investigative Site

    Clichy, 92110, France

  • Investigative Site

    Pessac, 33600, France

  • Investigative Site

    Rennes, 35000, France

  • Investigative Site

    Toulouse, 31000, France

  • Investigative Site

    Frankfurt, 60596, Germany

  • Investigative Site

    Hanover, 30625, Germany

  • Investigative Site

    Tübingen, 72076, Germany

  • Investigative Site

    Milan, 20122, Italy

  • Investigative Site

    Pisa, 56124, Italy

  • Investigative Site

    Chisinau, MD-2025, Moldova

  • Investigative Site

    Rotterdam, 3015 GD, Netherlands

  • Investigative Site

    Auckland, 1010, New Zealand

  • Investigative Site

    Bucharest, 021105, Romania

  • Investigative Site

    Birmingham, B15 2TT, United Kingdom

  • Investigative Site

    London, E1 1RF, United Kingdom

  • Investigative Site

    London, SE5 9RS, United Kingdom

  • Investigative Site

    Manchester, M8 5RB, United Kingdom

Conditions

Explore the condition pages connected to this study.