New drug combo trial aims to keep rare lymphoma at bay longer
NCT ID NCT05735834
Summary
This study is for adults with a rare, slow-growing blood cancer called splenic marginal zone lymphoma (SMZL) who have not yet had treatment. It aims to see if taking two drugs together (rituximab and zanubrutinib) is more effective at controlling the cancer and preventing it from getting worse than taking just one drug (rituximab). About 122 participants will be randomly assigned to one of the two treatment groups and followed for up to three years.
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Contacts and locations
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Locations
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A.O.U. Policlinico G. Rodolico-S. Marco
Catania, 95123, Italy
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ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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ASST Spedali Civili di Brescia
Brescia, 25123, Italy
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Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello
Palermo, 90146, Italy
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Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, 28100, Italy
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CHRU Nancy Brabois
Vandœuvre-lès-Nancy, 54511, France
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CHU de Grenoble
Grenoble, 38043, France
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Churchill Hospital
Oxford, OX3 7LE, United Kingdom
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Clatterbridge Cancer Centre
Liverpool, L7 8YA, United Kingdom
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Clinica Universidad de Navarra
Madrid, Spain
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Clinica Universidad de Navarra
Pamplona, Spain
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Guy's Hospital - Guy's and St. Thomas' NHS Foundation Trust
London, SE1 9RT, United Kingdom
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Hospedal Clinic de Barcelona
Barcelona, Spain
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Hospital 12 De Octubre
Madrid, Spain
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Hospital Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
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Hospital Clinico De Valencia
Valencia, Spain
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Hospital De Donostia
San Sebastián, Spain
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Hospital De Salamanca
Salamanca, Spain
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Hospital Gregorio Marañón
Madrid, Spain
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Hospital Ramon y Cajal
Madrid, Spain
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Hospital Universitario Cruces
Bilbao, Spain
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Hospital Universitario Miguel Servet
Zaragoza, Spain
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Hospital Vall d'Hebron
Barcelona, Spain
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Hospital Virgen Arrixaca
El Palmar, Spain
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Hospital del Mar
Barcelona, Spain
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Hôpital Lyon-Sud
Pierre-Bénite, 69495, France
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Hôpital Saint Louis
Paris, 75475, France
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INSELSPITAL, Bern University Hospital
Bern, 3010, Switzerland
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IRCCS AOU di Bologna
Bologna, 40138, Italy
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IRCCS IRST Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"
Meldola, 47014, Italy
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IRCCS Istituto Tumori Giovanni Paolo II
Bari, 70124, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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IRCCS Policlinico San Matteo
Pavia, Italy
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Institut Bergonié
Bordeaux, 33076, France
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Istitut Català d'Oncologia, Hospital Duran i Reynals
Barcelona, Spain
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Karolinska University Hospital
Stockholm, Sweden
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Medical University of Vienna
Vienna, Austria
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Oncology Institute of Southern Switzerland
Bellinzona, 6500, Switzerland
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Oslo University Hospital
Oslo, Norway
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Ospedale Santa Maria delle Croci
Ravenna, 48121, Italy
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Ospedale di Circolo e Fondazione Macchi - ASST dei Sette Laghi
Varese, 21100, Italy
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Policlinico Santa Maria alle Scotte
Siena, 53100, Italy
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St Olavs Hospital
Trondheim, Norway
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The Christie
Manchester, M20 4BX, United Kingdom
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The Royal Marsden NHS Foundation Trust
Sutton, SM2 5PT, United Kingdom
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USL-IRCCS of Reggio Emilia, Arcispedale Santa Maria Nuova
Reggio Emilia, 42123, Italy
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University College London Hospitals
London, NW1 2PG, United Kingdom
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University Hospital of Wales
Cardiff, CF14 4XW, United Kingdom
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University Hospitals Dorset
Bournemouth, BH7 7DW, United Kingdom
Conditions
Explore the condition pages connected to this study.