Major trial aims to tame debilitating autoimmune disease

NCT ID NCT05946941

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether an oral medication called deucravacitinib can safely reduce disease activity and improve symptoms for adults with active Sjögren's syndrome. About 774 participants will receive either the drug or a placebo for a year to see if it lessens overall disease severity, dryness, pain, and fatigue. The goal is to better control this chronic autoimmune condition, not to cure it, so ongoing treatment would likely be needed.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Local Institution - 0001

Groningen, 9713 GZ, Netherlands
Local Institution - 0002

Taichung, 40705, Taiwan
Local Institution - 0003

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1123AAO, Argentina
Local Institution - 0004

Sherbrooke, Quebec, J1L 0H8, Canada
Local Institution - 0005

Amiens, 80054, France
Local Institution - 0007

Antalya, 7058, Turkey (Türkiye)
Local Institution - 0008

Plovdiv, 4001, Bulgaria
Local Institution - 0009

Albuquerque, New Mexico, 87106, United States
Local Institution - 0011

Santiago de Surco, Lima region, 1111, Peru
Local Institution - 0012

Taichung, 40447, Taiwan
Local Institution - 0013

Bern, 3010, Switzerland
Local Institution - 0014

Lisbon, 1649-035, Portugal
Local Institution - 0015

Santiago de Chlie, Santiago Metropolitan, 8207257, Chile
Local Institution - 0016

Kansas City, Kansas, 66160, United States
Local Institution - 0017

Baton Rouge, Louisiana, 70836, United States
Local Institution - 0018

São Paulo, São Paulo, 04266-010, Brazil
Local Institution - 0019

Quilmes, Buenos Aires, 1878, Argentina
Local Institution - 0020

León, Guanajuato, 37000, Mexico
Local Institution - 0022

Jackson, Tennessee, 38305, United States
Local Institution - 0023

Guadalajara, Jalisco, 44620, Mexico
Local Institution - 0024

Bydgoszcz, 85-065, Poland
Local Institution - 0025

Paris, 75012, France
Local Institution - 0026

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Local Institution - 0027

Taipei, 100, Taiwan
Local Institution - 0028

Lisbon, 1050-078, Portugal
Local Institution - 0029

Milan, 20122, Italy
Local Institution - 0030

Birmingham, B15 2WB, United Kingdom
Local Institution - 0031

Freiburg im Breisgau, 79106, Germany
Local Institution - 0032

Viña del Mar, Región de Valparaíso, 2531172, Chile
Local Institution - 0033

Hamburg, 20095, Germany
Local Institution - 0034

Sankt Gallen, 9007, Switzerland
Local Institution - 0035

Yenimahalle, Ankara, 06500, Turkey (Türkiye)
Local Institution - 0036

Wroclaw, 54-049, Poland
Local Institution - 0037

Bogota D.C, 110221, Colombia
Local Institution - 0038

Mérida, Badajoz, 06800, Spain
Local Institution - 0040

Lublin, 20-412, Poland
Local Institution - 0041

Brasov, 500283, Romania
Local Institution - 0042

Gwangju, 61469, South Korea
Local Institution - 0043

Chía, Cundinamarca, 250001, Colombia
Local Institution - 0044

Istanbul, 34098, Turkey (Türkiye)
Local Institution - 0045

Taoyuan, 333, Taiwan
Local Institution - 0047

Jesus Maria, Lima region, 15076, Peru
Local Institution - 0048

Guadalajara, Jalisco, 44690, Mexico
Local Institution - 0049

Clearwater, Florida, 33765, United States
Local Institution - 0050

San Isidro, Alabama, 1643, Argentina
Local Institution - 0051

Würzburg, 97080, Germany
Local Institution - 0054

Warsaw, Masovian Voivodeship, 00-874, Poland
Local Institution - 0055

Porto Alegre, Rio Grande do Sul, 90560-030, Brazil
Local Institution - 0056

Trois-Rivières, Quebec, G8Z1Y2, Canada
Local Institution - 0057

Paris, 75651, France
Local Institution - 0059

Santander, Cantabria, 39008, Spain
Local Institution - 0060

Cannock, WS11 5XY, United Kingdom
Local Institution - 0061

Córdoba, X5004AUL, Argentina
Local Institution - 0063

Toronto, Ontario, M5T 2S8, Canada
Local Institution - 0064

Wroclaw, 53-224, Poland
Local Institution - 0065

Brescia, 25123, Italy
Local Institution - 0067

Denver, Colorado, 80230, United States
Local Institution - 0068

Santiago de Compostela, 15702, Spain
Local Institution - 0069

Rome, 00128, Italy
Local Institution - 0070

Grenoble, 38043, France
Local Institution - 0071

Seville, 41010, Spain
Local Institution - 0073

Bordeaux, 33075, France
Local Institution - 0074

Le Havre, 76083, France
Local Institution - 0075

Tübingen, 72076, Germany
Local Institution - 0076

Warsaw, 02-637, Poland
Local Institution - 0077

Athens, 11527, Greece
Local Institution - 0079

Munich, Bavaria, 80336, Germany
Local Institution - 0080

Warsaw, 02 665, Poland
Local Institution - 0081

Udine, 33100, Italy
Local Institution - 0083

Debrecen, 4032, Hungary
Local Institution - 0084

Krakow, Lesser Poland Voivodeship, 30-363, Poland
Local Institution - 0085

Bydgoszcz, 85-168, Poland
Local Institution - 0087

Vienna, A-1180, Austria
Local Institution - 0088

Ankara, 06100, Turkey (Türkiye)
Local Institution - 0089

Poznan, 60-693, Poland
Local Institution - 0090

Gyula, 5700, Hungary
Local Institution - 0091

Juiz de Fora, Minas Gerais, 36010-570, Brazil
Local Institution - 0092

Berlin, 10117, Germany
Local Institution - 0093

Wenzhou, Zhejiang, 325000, China
Local Institution - 0094

Changsha, Hunan, 410011, China
Local Institution - 0095

Guangzhou, Guangdong, 510080, China
Local Institution - 0097

Santiago, Santiago Metropolitan, 7500710, Chile
Local Institution - 0100

CABA, Buenos Aires, 1114, Argentina
Local Institution - 0101

Xi'an, Shaanxi, 710061, China
Local Institution - 0102

Shanghai, Shanghai Municipality, 200000, China
Local Institution - 0105

Rotterdam, 3015 GD, Netherlands
Local Institution - 0106

Belo Horizonte, Minas Gerais, 30130-100, Brazil
Local Institution - 0107

Paris, 75014, France
Local Institution - 0108

Larissa, 41110, Greece
Local Institution - 0109

City of Buenos Aires, 1425, Argentina
Local Institution - 0110

Seongdong-gu, Seoul, 04763, South Korea
Local Institution - 0111

Uberlândia, 38405-320, Brazil
Local Institution - 0112

A Coruña, 15006, Spain
Local Institution - 0114

San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain
Local Institution - 0116

Kaohsiung City, 83301, Taiwan
Local Institution - 0117

Graz, A-8036, Austria
Local Institution - 0118

Kanazawa, Ishikawa-ken, 9208641, Japan
Local Institution - 0119

Turku, 20520, Finland
Local Institution - 0120

Woodville South, South Australia, 5011, Australia
Local Institution - 0122

Sapporo, Hokkaido, 0608543, Japan
Local Institution - 0124

Naples, 80131, Italy
Local Institution - 0125

Monroe, Louisiana, 71203, United States
Local Institution - 0126

Seoul, 06591, South Korea
Local Institution - 0127

San Juan, 00918, Puerto Rico
Local Institution - 0128

Pisa, 56126, Italy
Local Institution - 0129

Sasebo, Nagasaki, 8571195, Japan
Local Institution - 0130

Duncansville, Pennsylvania, 16635, United States
Local Institution - 0131

Eagan, Minnesota, 55123, United States
Local Institution - 0133

Seattle, Washington, 98195, United States
Local Institution - 0134

Vancouver, British Columbia, V5Z 1L7, Canada
Local Institution - 0135

Kuopio, 70100, Finland
Local Institution - 0136

Santiago, Providencia, 7501126, Chile
Local Institution - 0137

CABA, 1405, Argentina
Local Institution - 0138

Summit, New Jersey, 07901, United States
Local Institution - 0139

Sendai, Miyagi, 980-8574, Japan
Local Institution - 0140

Augusta, Georgia, 30912, United States
Local Institution - 0141

Warsaw, Woj. Mazowieckie, 02-118, Poland
Local Institution - 0142

Kfar Saba, 4428164, Israel
Local Institution - 0143

San Juan, 00917, Puerto Rico
Local Institution - 0144

Allen, Texas, 75013, United States
Local Institution - 0145

Ramat Gan, IA, 5265601, Israel
Local Institution - 0146

Nagoya, Aichi-ken, 457-8511, Japan
Local Institution - 0147

Nagasaki, Nagasaki, 8528501, Japan
Local Institution - 0148

Kitakyushu-shi, Fukuoka, 807-8556, Japan
Local Institution - 0149

Wuhan, Hubei, 430030, China
Local Institution - 0150

Hohhot, Inner Mongolia, 10000, China
Local Institution - 0151

Shanghai, Shanghai Municipality, 200065, China
Local Institution - 0152

Hangzhou, Zhejiang, 314408, China
Local Institution - 0153

Beijing, Beijing Municipality, 100034, China
Local Institution - 0154

Suzhou, Jiangsu, 215006, China
Local Institution - 0155

Xiamen, Fujian, 361003, China
Local Institution - 0156

Beijing, Beijing Municipality, 100044, China
Local Institution - 0157

Shanghai Shi, Shanghai Sheng, 200011, China
Local Institution - 0158

Changsha, Hunan, 410024, China
Local Institution - 0159

Nanjing, Jiangsu, 210029, China
Local Institution - 0160

Beijing, Beijing Municipality, 100191, China
Local Institution - 0161

Ningbo, Zhejiang, 315010, China
Local Institution - 0162

Pingxiang, Jiangxi, 337099, China
Local Institution - 0164

Stockholm, 11361, Sweden
Local Institution - 0166

Gothenburg, 405 30, Sweden
Local Institution - 0167

Le Kremlin-Bictre, 94270, France
Local Institution - 0168

Barranquilla, Atlántico, 080003, Colombia
Local Institution - 0169

Mexico City, Mexico City, 11850, Mexico
Local Institution - 0170

Vitória, Espírito Santo, 29041-295, Brazil
Local Institution - 0171

Lima, Lima 26, Peru
Local Institution - 0172

Ghent, 9000, Belgium
Local Institution - 0173

Boston, Massachusetts, 02111, United States
Local Institution - 0174

Skokie, Illinois, 60076, United States
Local Institution - 0175

Plano, Texas, 75024, United States
Local Institution - 0176

Southampton, Hampshire, SO16 6YD, United Kingdom
Local Institution - 0177

Nanchang, Jiangxi, 330006, China
Local Institution - 0178

Chengdu, Sichuan, 610041, China
Local Institution - 0179

Ürümqi, Xinjiang Sheng, 830001, China
Local Institution - 0181

Hangzhou, Zhejiang, 310003, China
Local Institution - 0182

Taiyuan, Shan1xi, 030032, China
Local Institution - 0184

Mineola, New York, 11501, United States
Local Institution - 0185

Warsaw, 03-291, Poland
Local Institution - 0187

Baltimore, Maryland, 21224-2746, United States
Local Institution - 0188

Sapporo, Hokkaido, 0608648, Japan
Local Institution - 0189

Spokane, Washington, 99204, United States
Local Institution - 0190

Chuo-ku, Tokyo, 1048560, Japan
Local Institution - 0191

Yokohama, Kanagawa, 2458575, Japan
Local Institution - 0192

tabashi City, Tokyo, 1738610, Japan
Local Institution - 0193

Tsukuba, Ibaraki, 3058576, Japan
Local Institution - 0194

Hamamatsu, Shizuoka, 4313192, Japan
Local Institution - 0195

Shimotsugagun, Tochigi, 3210293, Japan
Local Institution - 0196

Bunkyo-ku, Tokyo, 1138519, Japan
Local Institution - 0197

Shinjuku, Tokyo, 1608582, Japan
Local Institution - 0198

Ōtsu, Shiga, 5250072, Japan
Local Institution - 0199

Helsinki, 00290, Finland
Local Institution - 0200

Valdivia, 5110683, Chile
Local Institution - 0201

Meguro-ku, Tokyo, 1528902, Japan
Local Institution - 0202

Kahoku-gun, Ishikawa-ken, 9200293, Japan
Local Institution - 0203

Santa Monica, California, 90404, United States
Local Institution - 0204

Shinagawa-ku, Tokyo, 1420054, Japan
Local Institution - 0205

Toyoake-shi, Aichi-ken, 470-1192, Japan
Local Institution - 0206

Kawasaki-shi, Kanagawa, 2168511, Japan
Local Institution - 0207

Kurashiki, Okayama-ken, 7100824, Japan
Local Institution - 0208

Meguro-ku, Tokyo, 1538515, Japan
Local Institution - 0209

Seoul, 5030, South Korea
Local Institution - 0210

Bunkyo-ku, Tokyo, 1138421, Japan
Local Institution - 0211

Nishinomiya-shi, Hyōgo, 6638501, Japan
Local Institution - 0212

Shenzhen, Guangdong, 518020, China
Local Institution - 0213

Nanchang, Jiangxi, 330006, China
Local Institution - 0214

Zhengzhou, Henan, 450052, China
Local Institution - 0215

Nanjing, Jiangsu, 210008, China
Local Institution - 0216

Santiago, 8350488, Chile
Local Institution - 0217

Wolverhampton, West Midlands, WV10 0QP, United Kingdom
Local Institution - 0218

San Francisco, California, 94143, United States
Local Institution - 0219

Bucharest, 011658, Romania
Local Institution - 0220

Cluj-Napoca, Cluj, 400006, Romania
Local Institution - 0221

Sofia, 1618, Bulgaria
Local Institution - 0222

La Palma, California, 90623, United States
Local Institution - 0223

Sarasota, Florida, 34239, United States
Local Institution - 0224

Salisbury, North Carolina, 28144, United States
Local Institution - 0226

Cooper City, Florida, 33024, United States
Local Institution - 0227

Katy, Texas, 77494, United States
Local Institution - 0228

Fullerton, California, 92835, United States
Local Institution - 0229

Lawrenceville, Georgia, 30046, United States

Conditions

Explore the condition pages connected to this study.

SJÖGREN´S SYNDROME