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Scientists create a detailed map of the nose and sinuses to uncover hidden differences

NCT ID NCT07692243

Knowledge-focused Sponsor: First Affiliated Hospital, Sun Yat-Sen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This observational study aims to create a detailed map of the lining of the nose and sinuses by comparing tissue samples from different areas. Researchers will collect samples from adults undergoing sinus surgery, including those with and without inflammatory disease. By analyzing tissue structure, gene activity, and immune cells, they hope to identify site-specific features that could improve understanding of conditions like chronic sinusitis and nasal polyps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could create a detailed map of the nose and sinus lining, helping future research on chronic sinusitis and nasal polyps.
What could go wrong
This is an observational study, not a treatment trial. It will not directly benefit participants and may not lead to immediate medical advances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include adult participants undergoing clinically indicated sinonasal surgery. Sinonasal mucosal tissue samples may be collected from different anatomical sites of the nasal cavity and paranasal sinuses when available during the planned surgical procedure. Participants may include individuals with sinonasal inflammatory disease as well as individuals undergoing surgery for non-inflammatory sinonasal conditions, depending on clinical availability and protocol requirements. No study-specific treatment or intervention will be assigned.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Scheduled for clinically indicated sinonasal surgery. * Sinonasal mucosal tissue can be collected during surgery without significant additional risk. * Able and willing to provide written informed consent. * Relevant clinical information is available. Exclusion Criteria: * Unable or unwilling to provide informed consent. * Younger than 18 years of age. * Tissue collection may interfere with standard care or increase surgical risk. * History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa. * Active systemic infection or severe systemic disease affecting study participation or interpretation. * Use of systemic corticosteroids, immunosuppressants, or biologics within 4 weeks before surgery. * Insufficient or poor-quality tissue for planned analyses.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Human sinonasal mucosal spatial atlas

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • the First Affiliated Hospital of Sun Yat-sen University

    RECRUITING

    Guangzhou, Guangdong, 510030, China