New drug aims to slash debilitating pain crises for sickle cell patients

NCT ID NCT06439082

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an investigational drug called crizanlizumab can reduce the frequency of painful vaso-occlusive crises in people with sickle cell disease. It will involve about 315 adolescents and adults who experience frequent pain crises, comparing the drug against a placebo. Participants can continue their standard hydroxyurea therapy, and the study will track how many crises require medical care over a year.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Augusta University Georgia
RECRUITING

Augusta, Georgia, 30912, United States

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Childrens Hospital at Montefiore
RECRUITING

The Bronx, New York, 10467, United States

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Childrens National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States

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East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States

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Norton Children s Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

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Novartis Investigative Site
RECRUITING

Salvador, Estado de Bahia, 41253-190, Brazil
Novartis Investigative Site
RECRUITING

São Luís, Maranhão, 65020-070, Brazil
Novartis Investigative Site
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Campinas, São Paulo, 13083-970, Brazil
Novartis Investigative Site
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Ribeirão Preto, São Paulo, 14048-900, Brazil
Novartis Investigative Site
RECRUITING

Sao Jose Rio Preto, São Paulo, 15090 000, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01232-010, Brazil
Novartis Investigative Site
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São Paulo, São Paulo, 08270-070, Brazil
Novartis Investigative Site
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Medellín, Antioquia, 050001, Colombia
Novartis Investigative Site
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Cali, Valle del Cauca Department, 760032, Colombia
Novartis Investigative Site
RECRUITING

Cali, Valle del Cauca Department, 760046, Colombia
Novartis Investigative Site
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Montería, 230001, Colombia
Novartis Investigative Site
RECRUITING

Ahero, Kisumu County, 40100, Kenya
Novartis Investigative Site
RECRUITING

Kisumu, 40100, Kenya
Novartis Investigative Site
RECRUITING

Kisumu, 54 40100, Kenya
Novartis Investigative Site
RECRUITING

Kampala, 101, Uganda
Southern Specialty Research
RECRUITING

Flowood, Mississippi, 39232, United States

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Spoknwrdclinicaltrials
RECRUITING

Easton, Pennsylvania, 18045, United States

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The Johns Hopkins University School of Medicine
RECRUITING

Baltimore, Maryland, 21205, United States

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U of TX Health Science Ct
RECRUITING

Houston, Texas, 77030, United States

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University Of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

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University of Florida
RECRUITING

Jacksonville, Florida, 32209, United States

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WCG Sonar Clinical Research
RECRUITING

Riverdale, Georgia, 30274, United States

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Wake Forest University Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE