Scientists dig into skin germs to solve sickle cell leg ulcer mystery

NCT ID NCT02156102

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 22 times

Summary

This study looked at 405 adults with sickle cell disease to understand why some develop chronic leg ulcers. Researchers collected skin swabs, blood, saliva, and hair samples, and asked participants about their life and environment. The goal was to identify bacteria and social factors linked to ulcers, not to test a new treatment. Findings may help design future therapies.

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Contacts and locations

Locations

  • Montefiore Medical Center/Albert Einstein College of Medicine

    The Bronx, New York, 10467, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • University of Sierra Leone, College of Medicine and Allied Health Services

    Freetown, Sierra Leone

Conditions

Explore the condition pages connected to this study.