Drug trial aims to protect Kids' brains from sickle cell damage

NCT ID NCT04218084

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

Summary

This study tested whether a medication called voxelotor could help protect children with sickle cell disease from strokes. It involved about 224 children, aged 2 to 15, who were at risk for stroke due to abnormal blood flow in their brains. Researchers compared the drug to a placebo to see if it could improve blood flow measurements and reduce the risk of stroke over time.

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Contacts and locations

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Locations

Abu El Rich Hospital, Cairo University Hospital

Cairo, 11562, Egypt
Ain Shams University Hospital- Clinical Research Center (MASRI)

Cairo, Abassia, 11566, Egypt
Alexandria Clinical Research Center, Faculty of Medicine, Alexandria University

Alexandria, 21131, Egypt
Aminu Kano Teaching Hospital

Kano, 700233, Nigeria
Azienda Ospedaliera Universita' (AOU ) Padova

Padua, 35128, Italy
Azienda Ospedaliera Universita' (AOU) Padova

Padua, 35128, Italy
Azienda Ospedaliera Universitaria (A.O.U.) "Luigi Vanvitelli"

Napoli, 80138, Italy
Azienda Ospedaliera Universitaria Meyer "A.O.U. Meyer" - SOC "Oncologia, Ematologia e TCSE"

Florence, 50139, Italy
Barau Dikko Teaching/Kaduna State University

Kaduna, 800212, Nigeria
Barts Health NHS Trust

London, E1 1BB, United Kingdom
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Boston Children's Hospital - Clinical Research Pharmacy

Boston, Massachusetts, 02115, United States
Children's Healthcare of Atlanta: Hughes Spalding

Atlanta, Georgia, 30303, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
College of Medicine, University of Ibadan

Ibadan, Oyo State, 200212, Nigeria
Department of Child Health, University of Ghana Medical School, College of Health Sciences, Korle-Bu

Accra, Greater Accra Region, GA-221-1570, Ghana
Gertrude's Children Hospital

Nairobi, 100, Kenya
KEMRI CRDR Clinical Research Annex

Nairobi, 00100, Kenya
Kemri/Crdr,Siaya,Kemri Clinical Research Annex

Kisumu, Siaya County, 40600, Kenya
King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard - Health

Riyadh, 11481, Saudi Arabia
Komfo Anokye Teaching Hospital

Kumasi, Ashanti Region, 00233, Ghana
Lagos University Teaching Hospital

Surulere, Lagos, 100254, Nigeria
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medical University of South Carolina: Investigational Drug Services

Charleston, South Carolina, 29425, United States
Medical University of South Carolina: Shawn Jenkins Women's and Children's Hospital

Charleston, South Carolina, 29425, United States
Strathmore University Medical Centre

Nairobi, 00200, Kenya
Sultan َQaboos University Hospital

Muscat, Oman
Texas Children's Hospital

Houston, Texas, 77030, United States
Texas Children's Hospital - Investigational Pharmacy

Houston, Texas, 77030, United States
Texas Children's Hospital- Wallace Tower

Houston, Texas, 77030, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University of Miami

Miami, Florida, 33136, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nigeria Teaching Hospital

Enugu, 460000, Nigeria
Zagazig University Hospital

Zagazig, Alsharkia, Egypt

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE