New drug cocktail aims to tackle tough lymphoma
NCT ID NCT06929624
First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times
Summary
This phase 3 trial tests whether adding the experimental drug SHR-A1912 to standard chemotherapy (R-GEMOX) helps people with relapsed or refractory diffuse large B-cell lymphoma. About 280 adults whose cancer came back after at least one prior treatment will be randomly assigned to receive either the new combo or standard chemo alone. The main goals are to see if more patients achieve complete remission and if overall survival improves.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SHR-A1912 (a targeted drug) combined with rituximab, gemcitabine, and oxaliplatin (chemotherapy)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with relapsed or refractory diffuse large B-cell lymphoma, potentially improving response rates and survival.
- What could go wrong
- This is an early-phase 3 trial, so results are not yet known. The added drug may increase side effects, and the benefit over standard therapy is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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