New drug cocktail aims to tackle tough lymphoma

NCT ID NCT06929624

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether adding the experimental drug SHR-A1912 to standard chemotherapy (R-GEMOX) helps people with relapsed or refractory diffuse large B-cell lymphoma. About 280 adults whose cancer came back after at least one prior treatment will be randomly assigned to receive either the new combo or standard chemo alone. The main goals are to see if more patients achieve complete remission and if overall survival improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SHR-A1912 (a targeted drug) combined with rituximab, gemcitabine, and oxaliplatin (chemotherapy)
What this could lead to
If successful, this combination could offer a new treatment option for people with relapsed or refractory diffuse large B-cell lymphoma, potentially improving response rates and survival.
What could go wrong
This is an early-phase 3 trial, so results are not yet known. The added drug may increase side effects, and the benefit over standard therapy is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Beijing Cancer Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100142, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Sun Yat-sen University Cancer Center

    RECRUITING

    Guangzhou, Guangdong, 510060, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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