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Low-Dose creatine hydrochloride shows promise in small safety study

NCT ID NCT07521059

Knowledge-focused Sponsor: Vireo Systems, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested the short-term safety of a low-dose creatine hydrochloride supplement (750 mg per day) in 11 healthy adults over 28 days. The goal was to see if this more soluble form of creatine is safe at lower doses than typical creatine supplements. No serious side effects were reported, but the study was very small and had no placebo group, so more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
creatine hydrochloride (a dietary supplement)
What this could lead to
If successful, this could support the safe use of low-dose creatine hydrochloride as a more efficient alternative to standard creatine supplements.
What could go wrong
This is a very small, early pilot study with only 11 healthy adults and no comparison group. Larger studies are needed to confirm safety and effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

11 people

The number who actually took part.

Started

May 2024

Finished

Oct 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * healthy adults Exclusion Criteria: * consumed creatine supplements in last 30 days significant medical conditions that could affect outcomes (e.g., diabetes)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Safety of short term creatine hydrochloride dosing

Contacts and locations

Locations

  • Princeton Consumer Research

    Raritan, New Jersey, 08869, United States