New rectal malaria drug could save kids in remote villages

NCT ID NCT06806956

First seen Feb 01, 2026 · Last updated May 10, 2026 · Updated 16 times

Summary

This study looks at whether giving a rectal medicine (rectal artesunate) followed by a 3-day course of artemisinin-based combination therapy (ACT) works as well as the standard injected treatment for severe malaria in children aged 6 months to 5 years. It involves over 2,000 children in Zambia and the Democratic Republic of Congo who live far from hospitals. The goal is to find a safe and effective way to treat severe malaria when quick referral to a health facility isn't possible.

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Contacts and locations

Locations

  • Tropical Diseases Research Centre

    Ndola, Copperbelt, 10101, Zambia

  • University of Kinshasa

    Kinshasa, Kinshasa City, Democratic Republic of the Congo

Conditions

Explore the condition pages connected to this study.