Could a laser switch reduce eye injections for severe Diabetes-Related vision loss?

NCT ID NCT06985706

Recruiting now Disease control Sponsor: Belfast Health and Social Care Trust Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether people with severe diabetic macular oedema (swelling in the center of the retina) can switch from regular eye injections to a gentle laser once the swelling drops below a certain level. 264 adults with type 1 or type 2 diabetes will be randomly assigned to either continue injections alone or switch to laser. The goal is to see if the laser works just as well at preserving vision while reducing the need for repeated injections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: anti-VEGF injections (ranibizumab, aflibercept, faricimab, brolucizumab) and subthreshold micropulse laser
What this could lead to: If successful, this could offer a way to reduce the number of injections needed for severe diabetic macular oedema by switching to laser when the swelling improves.
What could go wrong: This is a phase 3 trial, but it only includes people whose swelling has already improved with injections. The laser may not work as well as continuing injections, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE DIABETIC MACULAR OEDEMA

Contacts and locations

Locations

Birmingham and Midland Eye Centre
NOT_YET_RECRUITING

Birmingham, United Kingdom
Bristol Eye Hospital
NOT_YET_RECRUITING

Bristol, United Kingdom
Central Middlesex Hospital
RECRUITING

London, United Kingdom
Chelsea and Westminster Hospital
NOT_YET_RECRUITING

London, United Kingdom
East Surrey Hospital
NOT_YET_RECRUITING

Redhill, United Kingdom
Frimley Park Hospital
RECRUITING

Camberley, United Kingdom
Gloucestershire Royal Hospital
RECRUITING

Gloucester, United Kingdom
Hillingdon Hospital
RECRUITING

Uxbridge, United Kingdom
Hinchingbrooke Hospital
NOT_YET_RECRUITING

Huntingdon, United Kingdom
Hull Royal Infirmary
NOT_YET_RECRUITING

Hull, United Kingdom
James Cook Hospital
RECRUITING

Middlesbrough, United Kingdom
Kings College Hospital
RECRUITING

London, United Kingdom
Moorfields Eye Hospital
RECRUITING

London, United Kingdom
Queen's Medical Centre
NOT_YET_RECRUITING

Nottingham, United Kingdom
Royal Gwent Hospital
NOT_YET_RECRUITING

Newport, United Kingdom
Royal Liverpool University Hospital
RECRUITING

Liverpool, United Kingdom
Singleton Hospital
NOT_YET_RECRUITING

Swansea, United Kingdom
Sunderland Eye Hospital
RECRUITING

Sunderland, United Kingdom
Sussex Eye Hospital
NOT_YET_RECRUITING

Brighton, United Kingdom
The Royal Hospitals Belfast
RECRUITING

Belfast, United Kingdom
Torbay Hospital
NOT_YET_RECRUITING

Torquay, United Kingdom
University Hospital Southampton
NOT_YET_RECRUITING

Southampton, United Kingdom