Could a laser switch reduce eye injections for severe Diabetes-Related vision loss?
NCT ID NCT06985706
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether people with severe diabetic macular oedema (swelling in the center of the retina) can switch from regular eye injections to a gentle laser once the swelling drops below a certain level. 264 adults with type 1 or type 2 diabetes will be randomly assigned to either continue injections alone or switch to laser. The goal is to see if the laser works just as well at preserving vision while reducing the need for repeated injections.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
anti-VEGF injections (ranibizumab, aflibercept, faricimab, brolucizumab) and subthreshold micropulse laser
What this could lead to
If successful, this could offer a way to reduce the number of injections needed for severe diabetic macular oedema by switching to laser when the swelling improves.
What could go wrong
This is a phase 3 trial, but it only includes people whose swelling has already improved with injections. The laser may not work as well as continuing injections, and results may not apply to all patients.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SEVERE DIABETIC MACULAR OEDEMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Birmingham and Midland Eye Centre
NOT_YET_RECRUITINGBirmingham, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Bristol Eye Hospital
NOT_YET_RECRUITINGBristol, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Central Middlesex Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Chelsea and Westminster Hospital
NOT_YET_RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
East Surrey Hospital
NOT_YET_RECRUITINGRedhill, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Frimley Park Hospital
RECRUITINGCamberley, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Gloucestershire Royal Hospital
RECRUITINGGloucester, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hillingdon Hospital
RECRUITINGUxbridge, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hinchingbrooke Hospital
NOT_YET_RECRUITINGHuntingdon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hull Royal Infirmary
NOT_YET_RECRUITINGHull, United Kingdom
Contact Phone: •••-•••-••••
-
James Cook Hospital
RECRUITINGMiddlesbrough, United Kingdom
Contact Phone: •••-•••-••••
-
Kings College Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Moorfields Eye Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Queen's Medical Centre
NOT_YET_RECRUITINGNottingham, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Royal Gwent Hospital
NOT_YET_RECRUITINGNewport, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Royal Liverpool University Hospital
RECRUITINGLiverpool, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Singleton Hospital
NOT_YET_RECRUITINGSwansea, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Sunderland Eye Hospital
RECRUITINGSunderland, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Sussex Eye Hospital
NOT_YET_RECRUITINGBrighton, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
The Royal Hospitals Belfast
RECRUITINGBelfast, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Torbay Hospital
NOT_YET_RECRUITINGTorquay, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University Hospital Southampton
NOT_YET_RECRUITINGSouthampton, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••