Natural mouthwash from sesewanua plant shows promise against cavity germs
NCT ID NCT07434882
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether a mouthwash made from sesewanua (Clerodendrum fragrans) extract can reduce bacteria in the mouth, especially Streptococcus mutans, which causes cavities. One hundred female students used either a 1%, 2%, or 4% sesewanua mouthwash or plain water. Researchers measured bacterial levels before and after use to see if the plant extract helped.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sesewanua (Clerodendrum fragrans) extract mouthwash
- What this could lead to
- If it works, this could point toward a natural mouthwash alternative to reduce cavity-causing bacteria.
- What could go wrong
- This is a small, early study with only 100 participants, all young women in one dormitory. Results may not apply to the general population, and the effect may be weak or no better than water.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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100 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1. Female students registered as residents of the female dormitory at the Manado Ministry of Health Polytechnic during the study period. 2. Age ≥17 years. 3. Willing to sign written informed consent. 4. Good oral and general health status based on initial screening (no acute oral infections, severely inflamed gums, or other oral conditions requiring immediate treatment). 5. Not currently using medications or therapies that could modulate oral flora (e.g., systemic antibiotics, therapeutic oral antiseptics) in the past 2 weeks. 6. Able to follow standardized oral hygiene protocols (able to brush and rinse as instructed). Exclusion Criteria 1. Pregnancy or breastfeeding. 2. History of allergy to ingredients in mouthwash formulations (e.g., fragrances, parabens, sorbitol). 3. Use of antibiotics, antifungals, systemic steroids, or immunosuppressive medications in the 2 weeks before or during the study. 4. Invasive dental treatment or oral surgery in the past 1 month. 5. Systemic diseases that can affect saliva composition (e.g., uncontrolled diabetes, severe xerostomia, oral autoimmune diseases). 6. Active smoking or use of other tobacco products. 7. Non-compliance with protocols (e.g., failure to show up for sample collection).
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Poltekkkes Kemenkes manado
Manado, North Sulawesi, Indonesia