Enzyme vs. steroid: a new battle to tame Post-Tooth extraction swelling
NCT ID NCT07785596
First seen Aug 25, 2026 · Last updated Aug 27, 2026 · Updated 2 times
Summary
This trial compares two oral medications—serratiopeptidase, an enzyme, and dexamethasone, a steroid—to see which better controls pain and swelling after tooth extraction. Adults aged 18-70 undergoing extraction at a Karachi hospital will receive one of the two drugs, and their recovery will be tracked. The goal is to determine if serratiopeptidase can serve as a safer, effective alternative to steroids for managing post-operative inflammation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Oral serratiopeptidase (an enzyme) compared with oral dexamethasone (a corticosteroid) to reduce post-operative inflammation after tooth extraction.
- What this could lead to
- If serratiopeptidase works as well as dexamethasone, it could offer a non-steroid option to ease pain and swelling after tooth extractions, with fewer side effects.
- What could go wrong
- This is a small, single-center trial, and results may not apply broadly. Serratiopeptidase may not match dexamethasone's anti-inflammatory effect, and individual responses can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
110 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
-
Nov 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 weeks
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: * Patients aged 18-70 years * non-restorable teeth \& no prior use of recent dexamethasone or serratiopaptidase. * Able to provide informed consent and comply with follow-up. Exclusion criteria: * The patient excluded are having co-morbids specifically diabetes mellitus, nephropathy and hypertension, hyperthyroidism, non-compliant, * allergic to the dexamethasone or serratiopaptidase \& * those who refuse to involve in study
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Post-operative inflammation post-operative pain post-operative swelling (edema) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kgh
Karachi, Pakistan