Global trial aims to boost survival in aggressive lung cancer

NCT ID NCT05353257

Ongoing Disease control Sponsor: Shanghai Henlius Biotech Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding an immunotherapy drug called serplulimab to standard chemotherapy and radiation treatment helps people with limited-stage small cell lung cancer live longer without their cancer getting worse. It involves over 500 patients worldwide who are randomly assigned to receive either the new combination or the standard treatment plus a placebo. The main goal is to see if the new approach better controls the disease and extends survival.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

"Sotiria" Thoracic Diseases General Hospital of Athens

Athens, 115 27, Greece
Advent Health Orlando

Orlando, Florida, 32804, United States
Affiliated Hospital of Hebei University

Baoding, Hebei, 071000, China
Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266031, China
Anhui Chest Hospital

Hefei, Anhui, 230031, China
Baoji Central Hospital

Baoji, Shanxi, 721008, China
Beijing Cancer Hospital

Beijing, Beijing Municipality, 100142, China
Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China
Cancer Specialists of North Florida

Jacksonville, Florida, 32257, United States
Cangzhou People's Hospital

Cangzhou, Hebei, 061019, China
Chongqing University Cancer Hospital

Chongqing, Chongqing Municipality, 400030, China
Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708, United States
Clinic of Oncology, Pauls Stradins Clinical university hospital

Riga, LV-1002, Latvia
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Eastern Connecticut Hematology & Oncology Associates

Norwich, Connecticut, 06360, United States
Emad Ibrahim, MD, Inc

Redlands, California, 92373, United States
Fejer County Szent Gyorgy University Teaching Hospital

Székesfehérvár, 8000, Hungary
First Affiliated Hospital of Gannan Medical University

Ganzhou, Jiangxi, 341001, China
First Affiliated Hospital of Xi'an Jiaotong University

Xi’an, Shanxi, 710061, China
Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200032, China
Fujian Cancer Hospital

Fuzhou, Fujian, 350011, China
Gabrail Cancer Center

Canton, Ohio, 44718, United States
Ganzhou Cancer Hospital

Ganzhou, Jiangxi, 341005, China
General Hospital of Athens "Alexandra"

Athens, 11528, Greece
General University hospital in Prague (Oncology department)

Prague, 128 08, Czechia
Guangxi Medical University Cancer Hospital

Nanning, Guangxi, 530021, China
Gungzhouyikedaxuefushuzhongliuyiyuan

Guangzhou, Guangzhou, 510095, China
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150000, China
Health Partners

Bloomington, Minnesota, 55425, United States
Henan Cancer Hospital

Zhengzhou, Henan, 450008, China
Hong Kong United Oncology Centre

Hong Kong, Hong Kong, 999077, China
Hospital German Trias i Pujol/ ICO Badalona

Badalona, 8916, Spain
Hospital Gregorio Marañon

Madrid, 28007, Spain
Hospital Marques de Valdecilla

Valdecilla, 39008, Spain
Hospital Quironsalud Sagrado Corazón

Seville, 41013, Spain
Hospital St. Jansdal

Harderwijk, 3844, Netherlands
Hospital Universitario Puerta de Hierro

Madrid, 2822, Spain
Hospital Universitario Reina Sofía

Córdoba, 14004, Spain
Hospital Universitario de Badajoz

Badajoz, 6006, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 8025, Spain
Hubei Cancer Hospital

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital

Changsha, Hunan, 410013, China
Innova Schar Cancer Insitute

Fairfax, Virginia, 22031, United States
Isala Hospital

Zwolle, 8025, Netherlands
Jiamusi Cancer Hospital

Jiamusi, Heilongjiang, 154007, China
Jilin Cancer Hospital

Changchun, Jilin, 130000, China
Kaiser Permanente Northwest

Portland, Oregon, 97229, United States
Kansas University Mediacal Center

Fairway, Kansas, 66205, United States
Karl Landsteiner Institut für Lungenforschung und pneumologische Onkologie, c/o Klinik Floridsdorf Abteilung für Innere Medizin und Pneumologie

Vienna, 1210, Austria
Karl Landsteiner Institute for Lung Research and Pneumological Oncology, c/o Klinik Floridsdorf Department for Inner Medicine und Pneumology

Vienna, 1210, Austria
Kliniken der Stadt Cologne GmbH

Cologne, 51109, Germany
Klinikum Klagenfurt am Worthersee

Klagenfurt, 9020, Austria
Klinikum Klagenfurt am Wörthersee

Klagenfurt, 9020, Austria
Liaoning Cancer Hospital & Institute

Shenyang, Liaoning, 110042, China
Linyi Tumor Hospital

Linyi, Shandong, 276002, China
Lung and Chest Cancer Clinic, National Institute of Oncology

Warsaw, 02-781, Poland
Lutheran Medical Center - Cancer Centers of Colorado

Golden, Colorado, 80401, United States
MedPoloniaSp. z o.o.

Poznan, 60-693, Poland
Mid Florida Hematology and Oncology Center

Orange City, Florida, 32763, United States
Millennium Research & Clinical Development

Houston, Texas, 77090, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Napa Research

Pompano Beach, Florida, 33064, United States
Nemocnice AGEL Ostrava-Vítkovice

Ostrava-Vitkovice, 703 00, Czechia
Nemocnice AGEL Ostrava-Vítkovice

Ostrava-Vítkovice, 703 00, Czechia
New York City Health+HospitalsCorporation Elmhurst Hospital Center

Elmhurst, New York, 11373, United States
Northern Jiangsu people's Hospital

Yangzhou, Jiangsu, 210008, China
Northwell Health

Queens, New York, 11040, United States
Northwest Medical Specialties

Tacoma, Washington, 98405, United States
OPN-Glendale

Arcadia, California, 91007, United States
OPN-Los Alamitos

Los Alamitos, California, 90720, United States
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Pontchartrain Cancer Center

Covington, Louisiana, 70433, United States
Pro Research Tools, INC DBA Lumi Research

Kingwood, Texas, 77339, United States
Providence Medical Foundation

Santa Rosa, California, 95403, United States
Pulmonary Institute of Torokbalint

Törökbálint, 2045, Hungary
Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China
Queen Elizabeth Hospital

Hong Kong, Hong Kong, 999077, China
Queen Mary Hospital

Hong Kong, Hong Kong, 999077, China
Renown Health

Reno, Nevada, 89502, United States
Riga East University Hospital, Latvian Oncology Center

Riga, LV 1079, Latvia
Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Shanghai Chest Hospital

Shanghai, Shanghai Municipality, 200030, China
Shanxi Provincial Cancer Hospital

Taiyuan, Shanxi, 030013, China
Shenyang The Tenth People's Hospital

Shenyang, Liaoning, 110044, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310000, China
Southern California Permanente Group

Los Angeles, California, 90034, United States
Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, 510030, China
TaiHe Hospital Affiliated Hospital of Hubei University of Medicine

Shiyan, Hubei, 442000, China
Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, 317000, China
Tangshan People's Hospital

Tangshan, Hebei, 063001, China
The 1st Affiliated Hospital of WMU

Wenzhou, Zhejiang, 325000, China
The Center for Cancer and Blood Disorders

Fort Worth, Texas, 76104, United States
The First Affiliated Hospital of Bengbu Medical College

Bengbu, Anhui, 233099, China
The First Affiliated Hospital of Chongqing Medical

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Guangdong Pharmaceutical University

Guangzhou, Guangdong, 510000, China
The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, 471000, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, Henan, 453100, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First People's Hospital Of Changde City

Changde, Hunan, 415000, China
The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China
The Second Affiliated Hospital of Guilin Medical University

Guilin, Guangxi, 541100, China
The Second People's Hospital Of Yibin

Sichuan, Yibin, 644000, China
The Second Xiangya Hospita

Changsha, Hunan, 410008, China
The University of Texas - Hope Cancer Center

Tyler, Texas, 75701, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Tianjin Medical University Cancer Institute & Hospital

Tianjin, Tianjin Municipality, 300052, China
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, 300052, China
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology

Wuhan, Hubei, 430030, China
Tricounty Hematology and Oncology Associates

Massillon, Ohio, 44646, United States
Tulane University

New Orleans, Louisiana, 70112, United States
University Hospital Brno

Brno, 625 00, Czechia
University Hospital Brno (Clinic For Lung Diseases and Tuberculosis)

Brno, 625 00, Czechia
University Hospital La Fe

Valencia, 46026, Spain
University Hospital Motol

Prague, 150 06, Czechia
University Hospital Motol (Pneumology Clinic 2.LF UK and FN Motol)

Prague, Czechia
University Hospital Olomouc (Oncology Clinic)

Olomouc, 775 20, Czechia
University Hospital Ostrava

Ostrava-Poruba, Czechia
University Hospital Ostrava (oncology department)

Ostrava-Poruba, 570852, Czechia
University hospital Schleswig-Holstein

Travemünde, 23538, Germany
Wenzhou University Hospital

Wenzhou, Shanghai Municipality, 200032, China
West China Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Xiangya Hospital Central South University

Changsha, Hunan, 410013, China
Xuzhou Central Hospital

Xuzhou, Jiangsu, 221000, China
Yuhang Branch of the First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, 310003, China
Yunnan Cancer Hospital

Kunming, Yunnan, 650118, China
Zhejiang Cancer Hospital

Hangzhou, Zhejiang, 310005, China
Zhongnan hospital of wuhan university

Wuhan, Hubei, 430071, China
Zhongshan Hospital of Fudan University

Shanghai, Shanghai Municipality, 200032, China

Conditions

Explore the condition pages connected to this study.

LIMITED STAGE SMALL CELL LUNG CANCER