New hope for young adults with hard-to-treat obesity: drug plus lifestyle beats lifestyle alone

NCT ID NCT05574439

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 26 times

Summary

This study tested whether adding the drug semaglutide to lifestyle counseling helps young adults (18-28) with early-onset obesity who previously did not lose enough weight through lifestyle changes alone. About 180-270 participants were split into groups based on their past response to lifestyle treatment. Those who had not lost enough weight were given either semaglutide or a placebo for 68 weeks. The main goal was to see how much their BMI changed.

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Contacts and locations

Locations

  • Holbæk University Hospital

    Holbæk, Region Zeeland, 4300, Denmark

  • University of Copenhagen, Department of Biomedical Sciences

    Copenhagen, 2200, Denmark

Conditions

Explore the condition pages connected to this study.