Breathing easy at the dentist: new gas calms nerves and pain
NCT ID NCT00643838
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a gas called Kalinox, a mix of nitrous oxide and oxygen, to help patients relax during dental care. It included 549 anxious or phobic patients, young children, and mentally disabled adults across 36 French dental centers. The goal was to see if the gas reduces pain and makes dental visits easier for both patients and dentists.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Kalinox (50% nitrous oxide / 50% oxygen premix)
- What this could lead to
- If successful, this could provide a safe and effective sedation option for anxious dental patients, reducing pain and fear during procedures.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. The gas mix may not work for all patients, and side effects like dizziness or nausea are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Primary dental care centers
Clermont-Ferrand, France