New pill shows promise for kids with rare swelling disorder

NCT ID NCT06467084

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 33 times

Summary

This study tested an oral drug called sebetralstat in 36 children aged 2 to 11 with hereditary angioedema (HAE) Types I or II, a condition causing sudden painful swelling. The main goal was to check safety and how the body processes the drug. Researchers also measured how quickly symptoms improved after an attack. The medicine is designed to control attacks, not cure the condition.

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Contacts and locations

Locations

  • KalVista Investigative Site

    Birmingham, Alabama, 35209, United States

  • KalVista Investigative Site

    Scottsdale, Arizona, 85251, United States

  • KalVista Investigative Site

    San Diego, California, 92123, United States

  • KalVista Investigative Site

    Santa Monica, California, 90404, United States

  • KalVista Investigative Site

    Evansville, Indiana, 47715, United States

  • KalVista Investigative Site

    Wheaton, Maryland, 20902, United States

  • KalVista Investigative Site

    St Louis, Missouri, 63141, United States

  • KalVista Investigative Site

    Toledo, Ohio, 43560, United States

  • KalVista Investigative Site

    Hershey, Pennsylvania, 17011, United States

  • KalVista Investigative Site

    Dallas, Texas, 75231, United States

  • KalVista Investigative Site

    Edmonton, Alberta, T6G 2B7, Canada

  • KalVista Investigative Site

    Lille, 59000, France

  • KalVista Investigative Site

    Marseille, 13005, France

  • KalVista Investigative Site

    Paris, 75012, France

  • KalVista Investigative Site

    Frankfurt am Main, 60590, Germany

  • KalVista Investigative Site

    Frankfurt am Main, 60596, Germany

  • KalVista Investigative Site

    Haifa, 31048, Israel

  • KalVista Investigative Site

    Petah Tikva, 4920235, Israel

  • KalVista Investigative Site

    Tel Aviv, 6423906, Israel

  • KalVista Investigative Site

    Milan, 20097, Italy

  • KalVista Investigative Site

    Padova, 35128, Italy

  • KalVista Investigative Site

    Rome, 00133, Italy

  • KalVista Investigative Site

    Kawagoe, 350-8550, Japan

  • KalVista Investigative Site

    Tokyo, 113-8431, Japan

Conditions

Explore the condition pages connected to this study.