Gentler chemo tested to save 'Bubble Boy' babies

NCT ID NCT03619551

Ongoing Disease control Sponsor: Center for International Blood and Marrow Transplant Research Source: ClinicalTrials.gov ↗

Summary

This study is for infants with a severe genetic immune deficiency called SCID. It compares two different, lower doses of chemotherapy given before a stem cell transplant. The goal is to see if a lower dose can help the baby's new immune system develop properly while causing fewer short and long-term side effects. Doctors will measure success by whether the child can respond to vaccines after the transplant.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

All Children's Hospital

St. Petersburg, Florida, 33701, United States
Cancer Care Manitoba/University of Manitoba

Winnipeg, Winnipeg, MB, Canada
Cardinal Glennon Children's Medical Center

St Louis, Missouri, 63104, United States
Centre Hospitalier Universitaire Sainte-Justine

Montreal, Montreal, QC, Canada
Children's Healthcare of Atlanta at Egleston

Atlanta, Georgia, 30329, United States
Children's Hospital / LSUHSC

New Orleans, Louisiana, 70118, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Children's Medical Center Dallas

Dallas, Texas, 75235, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cohen Children's Medical Center

Queens, New York, 11040, United States
Comer Children's Hospital/University of Chicago Medicine

Chicago, Illinois, 60637, United States
Dana Farber Cancer Institute - Peds

Boston, Massachusetts, 02115, United States
Duke University Medical Center; Pediatric Blood and Marrow Transplant

Durham, North Carolina, 27705, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Helen DeVos Children's

Grand Rapids, Michigan, 49503, United States
Indiana University Hospital/Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Levine Children's Hospital

Charlotte, North Carolina, 28203, United States
Mayo Clinic Arizona and Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Memorial Sloan Kettering Cancer Center - Peds

New York, New York, 10065, United States
Morgan Stanley Children's Hospital of New York-Presbyterian - Columbia University Medical Center

New York, New York, 10032, United States
Nebraska Medicine

Omaha, Nebraska, 68198, United States
Oregon Health and Science University

Portland, Oregon, 97239-3098, United States
Rady Children's Hospital, San Diego

San Diego, California, 92123, United States
Shands HealthCare & University of Florida

Gainesville, Florida, 32610, United States
The Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
The Hospital for Sick Children

Toronto, Ontario, M5G 1E8, Canada
The University of Michigan

Ann Arbor, Michigan, 48109, United States
UCLA Center for Health Sciences

Los Angeles, California, 90095, United States
Univeristy of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California San Francisco Medical Center - Peds

San Francisco, California, 94143, United States
University of Colorado - Children's Hospital

Aurora, Colorado, 80045, United States
University of Iowa Hospitals & Clinics

Iowa City, Iowa, 52242, United States
University of Miami/Jackson Memorial Hospital

Miami, Florida, 33136, United States
University of Minnesota Blood and Marrow Transplant Program - Pediatrics

Minneapolis, Minnesota, 55455, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Utah Blood and Marrow Transplant Program-Peds

Salt Lake City, Utah, 84112, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Westchester Medical Center

Valhalla, New York, 10595, United States

Conditions

Explore the condition pages connected to this study.

SCID