Can a single injection tame a hidden heart risk?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Participants who have fully understood the study, voluntarily provided written informed consent, and are able to comply with the requirements and restrictions specified in the informed consent form. 2\. Male or female participants aged 18 to 65 years, inclusive. 3\. At screening, male participants must weigh at least 50 kg and female participants must weigh at least 45 kg, with a body mass index (BMI) between 19.0 and 28.0 kg/m², inclusive. 4\. For participants required to have elevated lipoprotein(a) \[Lp(a)\], screening Lp(a) must be ≥75 nmol/L or ≥30 mg/dL. The 30 mg dose cohort may include participants with or without elevated Lp(a), as specified in the protocol. 5\. At screening, physical examination, vital signs, hematology, urinalysis, serum chemistry, coagulation tests, viral serology, and glycated hemoglobin results, except for Lp(a), must be normal or show only minor abnormalities considered not clinically significant by the investigator. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must not exceed the upper limit of normal. 6\. Twelve-lead electrocardiogram findings must be normal or considered not clinically significant by the investigator, with QTcF \<450 ms. 7\. Participants and their partners must have no plans for pregnancy during the study and for 6 months after administration of the study intervention. Participants must agree to use effective contraception during this period. Hormonal contraceptives are prohibited during the study. Participants must not donate sperm or ova for reproductive or assisted reproductive purposes. Exclusion Criteria: * 1\. Women who are pregnant or breastfeeding; women of childbearing potential with a positive pregnancy test; or women of childbearing potential who have had unprotected sexual intercourse within 14 days before the first dose. 2\. Any disease or medical history considered by the investigator to alter or increase bleeding tendency, including but not limited to acute gastritis, gastrointestinal ulcer, allergic purpura, systemic lupus erythematosus, previous intracranial or intraocular hemorrhage, hemophilia, or von Willebrand disease. 3\. A clinically significant acute drug or food allergic reaction within 2 weeks before screening; an allergic constitution, such as allergy to two or more drugs, foods, or pollens; a history of allergic disease such as asthma, urticaria, or eczematous dermatitis; or known or suspected hypersensitivity or clinically significant reaction to the study intervention, related drugs, placebo, or any excipient. 4\. Positive test result for hepatitis B surface antigen, hepatitis C virus antibody, human immunodeficiency virus antibody, or Treponema pallidum-specific antibody. 5\. Any of the following prior to the first dose: * Administration of a small interfering RNA (siRNA) or antisense oligonucleotide within 18 months; * Use of any metabolic enzyme or transporter inhibitor or inducer within 2 weeks; * Use of any prescription drug, over-the-counter drug, traditional Chinese medicine, herbal product, dietary supplement, vitamin, or health supplement within 2 weeks. 6\. Drug abuse, excessive alcohol consumption, or excessive smoking, including: * A history of drug abuse or a positive urine drug screen at screening; * Average alcohol consumption of more than 14 units per week within 3 months before screening, a positive alcohol breath test at screening, or inability to abstain completely from alcohol-containing food or beverages during the study; * Average smoking of more than 5 cigarettes per day within 3 months before screening, or inability to abstain from tobacco products during the study. 7\. Blood donation, including component donation, or blood loss ≥400 mL within 3 months before screening; blood donation or blood loss ≥200 mL or receipt of a blood transfusion within 1 month before screening; or planned donation of blood or blood components during the study or within 1 month after study completion. 8\. Difficulty with blood collection, inability to tolerate repeated venipuncture, or a clinically significant history of needle or blood phobia as judged by the investigator. 9\. Dysphagia or special dietary requirements that prevent compliance with the standardized diet required by the study. 10\. Receipt of a live vaccine, live attenuated vaccine, or any vaccine containing live viral components within 3 months before screening, or planned receipt of such a vaccine during the study or within 1 month after study completion. 11\. Severe trauma or major surgery requiring general anesthesia within 3 months before screening, or planned surgery during the study or within 3 months after study completion, except procedures performed under local anesthesia. 12\. Participation within 3 months before screening in, or current participation in, any interventional clinical study involving administration of an investigational drug or vaccine, including another clinical study of SAL0195 or another cohort of this study. 13\. Any clinically significant disease, medical history, infectious disease, or other condition that, in the investigator's judgment, could interfere with completion of the study or significantly alter drug absorption, metabolism, or elimination, including clinically significant respiratory, cardiovascular, gastrointestinal, genitourinary, hematologic, endocrine, neurologic, psychiatric, or malignant disease, or relevant gastrointestinal, renal, or gallbladder surgery. 14\. Poor compliance or any other factor that, in the investigator's judgment, makes the participant unsuitable for participation in the study.