Experimental drug tested to stop dangerous, unending seizures

NCT ID NCT02477618

Completed Disease control Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether an experimental drug called SAGE-547 could help patients with a severe, life-threatening form of continuous seizures that does not respond to standard medications. The trial involved 132 patients who were already in intensive care and receiving strong anesthetic drugs to suppress their seizures. Researchers compared SAGE-547 to a placebo to see if it could help patients safely stop the anesthetic drugs and keep seizures under control.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Sage Investigational Site

Birmingham, Alabama, 35233, United States
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Mobile, Alabama, 36667, United States
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Phoenix, Arizona, 85006, United States
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Phoenix, Arizona, 85013, United States
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Little Rock, Arkansas, 27702, United States
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Fresno, California, 93721, United States
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Loma Linda, California, 92354, United States
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Los Angeles, California, 90027, United States
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Roseville, California, 95661, United States
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Sacramento, California, 95317, United States
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New Haven, Connecticut, 06510, United States
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Wilmington, Delaware, 19803, United States
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Washington D.C., District of Columbia, 20010, United States
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Gainesville, Florida, 32611, United States
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Jacksonville, Florida, 32209, United States
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Miami, Florida, 33155, United States
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Orlando, Florida, 32803, United States
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Sarasota, Florida, 34239, United States
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Tampa, Florida, 33613, United States
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Weston, Florida, 33331, United States
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Atlanta, Georgia, 30303, United States
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Atlanta, Georgia, 30322, United States
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Atlanta, Georgia, 30342, United States
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Honolulu, Hawaii, 96813, United States
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Honolulu, Hawaii, 96826, United States
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Boise, Idaho, 83706, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60612, United States
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Maywood, Illinois, 60153, United States
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Peoria, Illinois, 61637, United States
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Springfield, Illinois, 62702, United States
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Urbana, Illinois, 61801, United States
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Iowa City, Iowa, 52242, United States
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Wichita, Kansas, 67214, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40202, United States
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Baton Rouge, Louisiana, 70808, United States
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New Orleans, Louisiana, 70115, United States
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Portland, Maine, 04102, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21215, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02115, United States
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Boston, Massachusetts, 02118, United States
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Boston, Massachusetts, 02215, United States
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Newton, Massachusetts, 02462, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48201, United States
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Detroit, Michigan, 48202, United States
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East Lansing, Michigan, 48824, United States
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Grand Rapids, Michigan, 49503, United States
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Royal Oak, Michigan, 48073, United States
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Minneapolis, Minnesota, 55414, United States
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Rochester, Minnesota, 55905, United States
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Jackson, Mississippi, 39216, United States
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Kansas City, Missouri, 64108, United States
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St Louis, Missouri, 63110, United States
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Edison, New Jersey, 08818, United States
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Morristown, New Jersey, 08827, United States
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New Brunswick, New Jersey, 08901, United States
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Summit, New Jersey, 07901, United States
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Buffalo, New York, 14203, United States
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New York, New York, 10016, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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Port Jefferson, New York, 11777, United States
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Rochester, New York, 14642, United States
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Syracuse, New York, 13210, United States
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Durham, North Carolina, 27710, United States
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Winston-Salem, North Carolina, 27157, United States
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Akron, Ohio, 44308, United States
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Cincinnati, Ohio, 45229, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Toledo, Ohio, 43614, United States
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Portland, Oregon, 97213, United States
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Portland, Oregon, 97225, United States
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Portland, Oregon, 97239, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Philadelphia, Pennsylvania, 19140, United States
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Philadelphia, Pennsylvania, 19141, United States
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Philadelphia, Pennsylvania, 19147, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Charleston, South Carolina, 29425, United States
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Memphis, Tennessee, 38105, United States
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Nashville, Tennessee, 37232, United States
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Austin, Texas, 78723, United States
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Dallas, Texas, 75251, United States
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Salt Lake City, Utah, 84108, United States
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Salt Lake City, Utah, 84113, United States
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Burlington, Vermont, 05401, United States
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Seattle, Washington, 98105, United States
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Huntington, West Virginia, 25705, United States
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Morgantown, West Virginia, 26506, United States
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Wauwatosa, Wisconsin, 53226, United States
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Innsbruck, 6020, Austria
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Salzburg, 5020, Austria
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Vancouver, British Columbia, V6H3V4, Canada
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Hamilton, Ontario, L8L 2X2, Canada
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Kingston, Ontario, K7L3C9, Canada
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London, Ontario, N6A5A5, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2L 4M1, Canada
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Montreal, Quebec, H3A 2B4, Canada
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Montreal, Quebec, H3T 1C5, Canada
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Montreal, Quebec, H3T1C5, Canada
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Copenhagen, 2100, Denmark
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Tallinn, 10617, Estonia
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Tallinn, 13419, Estonia
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Tartu, 51014, Estonia
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Helsinki, 00029, Finland
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Kuopio, 70210, Finland
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Bron, 69677, France
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Dijon, 21079, France
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Lille, 59037, France
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Limoges, 87042, France
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Lyon, 69677, France
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Paris, 75851, France
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Hamburg, 22337, Germany
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Marburg, 35043, Germany
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Osnabrück, 49076, Germany
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Balassagyarmat, 2660, Hungary
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Budapest, 01134, Hungary
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Budapest, 1134, Hungary
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Ashkelon, 7830604, Israel
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Holon, 58100, Israel
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Holon, Israel
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Jerusalem, 91120, Israel
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Petah Tikva, 49100, Israel
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Tel Litwinsky, 52621, Israel
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Tzrifin, 70300, Israel
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Bologna, 40139, Italy
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Florence, 50139, Italy
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Milan, 20132, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Modena, 41100, Italy
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Modena, 41126, Italy
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Monza, 20900, Italy
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Perugia, 06129, Italy
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Reggio Calabria, 89124, Italy
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Rome, 00165, Italy
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Rome, 165, Italy
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Verona, 37126, Italy
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Enschede, 7512KZ, Netherlands
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Heerlen, 6419PC, Netherlands
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Maastricht, 6202AZ, Netherlands
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Nijmegen, 6525GA, Netherlands
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Belgrade, 11000, Serbia
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Belgrade, 11070, Serbia
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Niš, 18000, Serbia
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Novi Sad, 21000, Serbia
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Badalona, 8916, Spain
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Barakaldo, 48903, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Córdoba, 14004, Spain
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Granada, 18016, Spain
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L'Hospitalet de Llobregat, 08907, Spain
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Madrid, 28040, Spain
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Gothenburg, 413 45, Sweden
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Manchester, M6 8HD, United Kingdom
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Norfolk, NR4 7UY, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Staffordshire, ST3 6QG, United Kingdom
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Stoke-on-Trent, ST4 6QG, United Kingdom
Sage investigational Site

San Antonio, Texas, 78229, United States

Conditions

Explore the condition pages connected to this study.

SUPER-REFRACTORY STATUS EPILEPTICUS