New drug combo targets tough leukemia cases in early trial
NCT ID NCT00819546
First seen Apr 29, 2026 · Last updated May 02, 2026 · Updated 1 time
Summary
This early-phase study tests the safety of combining two drugs, RAD001 and PKC412, in about 29 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or not responded to standard treatments. The goal is to find the highest safe dose of RAD001 when given with PKC412, which blocks a faulty enzyme (FLT3) that helps cancer cells grow, while RAD001 targets another growth pathway (mTOR). This is not a cure, but aims to control the disease by slowing cancer cell growth.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MYELODYSPLASTIC SYNDROME are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Conditions
Explore the condition pages connected to this study.